The effects of whole‐body vibration amplitude on glucose metabolism, inflammation, and skeletal muscle oxygenation

Adeola A. Sanni, Anson M. Blanks, Cassandra C. Derella, Chase Horsager, Reva H. Crandall, Jacob Looney, Savanna Sanchez, Kimberly Norland, Bingwei Ye, Jeffrey Thomas, Xiaoling Wang, Ryan A. Harris

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    Abstract

    Whole-body vibration (WBV) is an exercise mimetic that elicits beneficial metabolic effects. This study aims to investigate the effects of WBV amplitude on metabolic, inflammatory, and muscle oxygenation responses. Forty women and men were assigned to a high (HI; n = 20, Age: 31 ± 6 y) or a low-amplitude group (LO; n = 20, Age: 33 ± 6 y). Participants engaged in 10 cycles of WBV [1 cycle =1 min of vibration followed by 30 s of rest], while gastrocnemius muscle oxygen consumption (mVO 2) was assessed using near-infrared spectroscopy (NIRS). Blood samples were collected PRE, POST, 1H, 3Hs, and 24H post-WBV and analyzed for insulin, glucose, and IL-6. In the LO group, Homeostatic Model Assessment for Insulin Resistant (HOMA-IR) at 3 h (0.7 ± 0.2) was significantly lower compared to PRE (1.1 ± 0.2; p = 0.018), POST (1.3 ± 0.3; p = 0.045), 1H (1.3 ± 0.3; p = 0.010), and 24H (1.4 ± 0.2; p < 0.001). In addition, at 24H, HOMA-IR was significantly lower in the LO when compared to the HI group (LO: 1.4 ± 0.2 vs. HI: 2.2 ± 0.4; p = 0.030). mVO 2 was higher (p = 0.003) in the LO (0.93 ± 0.29 ml/min/100 ml) when compared to the HI group (0.63 ± 0.28 ml/min/100 ml). IL-6 at 3H (LO: 13.2 ± 2.7 vs. HI: 19.6 ± 4.0 pg·ml −1; p = 0.045) and 24H (LO: 4.2 ± 1.1 vs. HI: 12.5 ± 3.1 pg·ml −1; p = 0.016) was greater in the HI compared to the LO group. These findings indicate that low-amplitude WBV provides greater metabolic benefits compared to high-amplitude WBV.

    Original languageEnglish
    Article numbere15208
    Pages (from-to)1-11
    Number of pages11
    JournalPhysiological Reports
    Volume10
    Issue number5
    Early online date3 Mar 2022
    DOIs
    Publication statusPublished - 3 Mar 2022

    Bibliographical note

    Funding Information:
    This study was funded by the NIDDK: 1R01DK117365‐01A1 (RAH and XW).

    Publisher Copyright:
    © 2022 The Authors. Physiological Reports published by Wiley Periodicals LLC on behalf of The Physiological Society and the American Physiological Society.

    Keywords

    • Physiology (medical)
    • Physiology
    • muscle oxygenation
    • glucose
    • insulin
    • exercise
    • myokines
    • IL-6

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