The effect of mGlu(8) deficiency in animal models of psychiatric diseases.

M Fendt, H Bürki, S Imobersteg, H van der Putten, K McAllister, Julian Leslie, D Shaw, Christian Holscher

Research output: Contribution to journalArticle

29 Citations (Scopus)

Abstract

The metabotropic glutamate receptor subtype 8 (mGlu(8)) is presynaptically located and regulates the release of the transmitter. Dysfunctions of this mechanism are involved in the pathophysiology of different psychiatric disorders. mGlu(8) deficient mice have been previously investigated in a range of studies, but the results are contradictory and there are still many open questions. Therefore, we tested mGlu(8)-deficient animals in different behavioral tasks that are commonly used in neuropsychiatric research. Our results show a robust contextual fear deficit in mGlu(8)-deficient mice. Furthermore, novel object recognition, chlordiazepoxide-facilitated extinction of operant conditioning and the acoustic startle response were attenuated by mGlu(8) deficiency. We found no changes in sensory processing, locomotor activity, prepulse inhibition, phencyclidine-induced changes in locomotion or prepulse inhibition, operant conditioning, conditioned fear to a discrete cue or in animal models of innate fear and post-traumatic stress disorder. We conclude that mGlu(8) might be a potential target for disorders with pathophysiological changes in brain areas where mGlu(8) modulates glutamate and gamma-amino butyric acid (GABA) transmission. Our data especially point to anxiety disorders involving exaggerated contextual fear, such as generalized anxiety disorders, and to conditions with disturbed declarative memory.
LanguageEnglish
Pages33-44
JournalGenes, Brain, and Behavior
Volume9
Publication statusPublished - 2010

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Animal Disease Models
Psychiatry
Fear
Operant Conditioning
Locomotion
Anxiety Disorders
Startle Reflex
Chlordiazepoxide
Phencyclidine
Butyric Acid
Post-Traumatic Stress Disorders
metabotropic glutamate receptor 8
Acoustics
Cues
Glutamic Acid
Animal Models
Brain
Research

Cite this

Fendt, M., Bürki, H., Imobersteg, S., van der Putten, H., McAllister, K., Leslie, J., ... Holscher, C. (2010). The effect of mGlu(8) deficiency in animal models of psychiatric diseases. Genes, Brain, and Behavior, 9, 33-44.
Fendt, M ; Bürki, H ; Imobersteg, S ; van der Putten, H ; McAllister, K ; Leslie, Julian ; Shaw, D ; Holscher, Christian. / The effect of mGlu(8) deficiency in animal models of psychiatric diseases. In: Genes, Brain, and Behavior. 2010 ; Vol. 9. pp. 33-44.
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Fendt, M, Bürki, H, Imobersteg, S, van der Putten, H, McAllister, K, Leslie, J, Shaw, D & Holscher, C 2010, 'The effect of mGlu(8) deficiency in animal models of psychiatric diseases.', Genes, Brain, and Behavior, vol. 9, pp. 33-44.

The effect of mGlu(8) deficiency in animal models of psychiatric diseases. / Fendt, M; Bürki, H; Imobersteg, S; van der Putten, H; McAllister, K; Leslie, Julian; Shaw, D; Holscher, Christian.

In: Genes, Brain, and Behavior, Vol. 9, 2010, p. 33-44.

Research output: Contribution to journalArticle

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AB - The metabotropic glutamate receptor subtype 8 (mGlu(8)) is presynaptically located and regulates the release of the transmitter. Dysfunctions of this mechanism are involved in the pathophysiology of different psychiatric disorders. mGlu(8) deficient mice have been previously investigated in a range of studies, but the results are contradictory and there are still many open questions. Therefore, we tested mGlu(8)-deficient animals in different behavioral tasks that are commonly used in neuropsychiatric research. Our results show a robust contextual fear deficit in mGlu(8)-deficient mice. Furthermore, novel object recognition, chlordiazepoxide-facilitated extinction of operant conditioning and the acoustic startle response were attenuated by mGlu(8) deficiency. We found no changes in sensory processing, locomotor activity, prepulse inhibition, phencyclidine-induced changes in locomotion or prepulse inhibition, operant conditioning, conditioned fear to a discrete cue or in animal models of innate fear and post-traumatic stress disorder. We conclude that mGlu(8) might be a potential target for disorders with pathophysiological changes in brain areas where mGlu(8) modulates glutamate and gamma-amino butyric acid (GABA) transmission. Our data especially point to anxiety disorders involving exaggerated contextual fear, such as generalized anxiety disorders, and to conditions with disturbed declarative memory.

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Fendt M, Bürki H, Imobersteg S, van der Putten H, McAllister K, Leslie J et al. The effect of mGlu(8) deficiency in animal models of psychiatric diseases. Genes, Brain, and Behavior. 2010;9:33-44.