The effect of consuming Palmaria palmata-enriched bread on inflammatory markers, antioxidant status, lipid profile and thyroid function in a randomised placebo-controlled intervention trial in healthy adults.

Philip Allsopp, William Crowe, Bojlul Bahar, Pádraigín A Harnedy, Emma S Brown, Sonja S Taylor, Thomas J Smyth, Anna Soler-Vila, Pamela J Magee, Chris I R Gill, Conall R Strain, Vicky Hegan, Martin Devaney, Julie M W Wallace, Paul Cherry, Richard J FitzGerald, J J Strain, John V O'Doherty, Emeir M McSorley

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Abstract

PURPOSEPalmaria palmata (P. Palmata) is reported to contain anti-inflammatory and antioxidant compounds albeit no study has investigated these effects in humans.METHODSA randomised parallel placebo-controlled human intervention study was carried out to investigate the effect of consuming P. Palmata (5 g/day) incorporated into a bread on serum markers of inflammation [C-reactive protein (CRP); cytokine analysis] with secondary analysis investigating changes in lipids (cholesterol, triglycerides), thyroid function [thyroid-stimulating hormone (TSH)] and antioxidant status ferric reducing antioxidant power. ANCOVA with baseline values as covariates, controlling for age, BMI, sex and smoking status, was used to compare differences between treatment groups over time . In vitro studies investigated the inflammatory activity of P. Palmata extracts (hot water, cold water and ethanol extract), protein extracts and associated protein hydrolysates using a Caco-2 inflammation cell model.RESULTSConsumption of P. Palmata-enriched bread significantly increased serum CRP (+16.1 %, P = 0.011), triglycerides (+31.9 %, P = 0.001) and TSH (+17.2 %, P = 0.017) when compared to the control group. In vitro evaluation of P. palmata extracts and protein hydrolysates identified a significant induction of IL-8 secretion by Caco-2 cells, and the hot water P. palmata extract was shown to increase adipocyte glycerol release (P <0.05).CONCLUSIONEvidence from this human study suggests that P. palmata stimulates inflammation, increases serum triglycerides and alters thyroid function; however, these changes are not likely to impact health as changes remained within the normal clinical range. The data from the in vitro study provided indications that IL-8 may contribute to the apparent immunostimulation noted in the human study.
LanguageEnglish
Pages1951-1962
Number of pages11
JournalEuropean Journal of Nutrition
Volume55
Issue number5
DOIs
Publication statusPublished - 31 Jul 2015

Fingerprint

Bread
Thyroid Gland
Antioxidants
Placebos
Protein Hydrolysates
Lipids
Triglycerides
Caco-2 Cells
Thyrotropin
Inflammation
Interleukin-8
C-Reactive Protein
Water
Adipocytes
Glycerol
Blood Proteins
Immunization
Reference Values
Anti-Inflammatory Agents
Ethanol

Keywords

  • Palmaria palmata
  • seaweed
  • lipid
  • inflammation
  • human

Cite this

Allsopp, Philip ; Crowe, William ; Bahar, Bojlul ; Harnedy, Pádraigín A ; Brown, Emma S ; Taylor, Sonja S ; Smyth, Thomas J ; Soler-Vila, Anna ; Magee, Pamela J ; Gill, Chris I R ; Strain, Conall R ; Hegan, Vicky ; Devaney, Martin ; Wallace, Julie M W ; Cherry, Paul ; FitzGerald, Richard J ; Strain, J J ; O'Doherty, John V ; McSorley, Emeir M. / The effect of consuming Palmaria palmata-enriched bread on inflammatory markers, antioxidant status, lipid profile and thyroid function in a randomised placebo-controlled intervention trial in healthy adults. In: European Journal of Nutrition. 2015 ; Vol. 55, No. 5. pp. 1951-1962.
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abstract = "PURPOSEPalmaria palmata (P. Palmata) is reported to contain anti-inflammatory and antioxidant compounds albeit no study has investigated these effects in humans.METHODSA randomised parallel placebo-controlled human intervention study was carried out to investigate the effect of consuming P. Palmata (5 g/day) incorporated into a bread on serum markers of inflammation [C-reactive protein (CRP); cytokine analysis] with secondary analysis investigating changes in lipids (cholesterol, triglycerides), thyroid function [thyroid-stimulating hormone (TSH)] and antioxidant status ferric reducing antioxidant power. ANCOVA with baseline values as covariates, controlling for age, BMI, sex and smoking status, was used to compare differences between treatment groups over time . In vitro studies investigated the inflammatory activity of P. Palmata extracts (hot water, cold water and ethanol extract), protein extracts and associated protein hydrolysates using a Caco-2 inflammation cell model.RESULTSConsumption of P. Palmata-enriched bread significantly increased serum CRP (+16.1 {\%}, P = 0.011), triglycerides (+31.9 {\%}, P = 0.001) and TSH (+17.2 {\%}, P = 0.017) when compared to the control group. In vitro evaluation of P. palmata extracts and protein hydrolysates identified a significant induction of IL-8 secretion by Caco-2 cells, and the hot water P. palmata extract was shown to increase adipocyte glycerol release (P <0.05).CONCLUSIONEvidence from this human study suggests that P. palmata stimulates inflammation, increases serum triglycerides and alters thyroid function; however, these changes are not likely to impact health as changes remained within the normal clinical range. The data from the in vitro study provided indications that IL-8 may contribute to the apparent immunostimulation noted in the human study.",
keywords = "Palmaria palmata, seaweed, lipid, inflammation, human",
author = "Philip Allsopp and William Crowe and Bojlul Bahar and Harnedy, {P{\'a}draig{\'i}n A} and Brown, {Emma S} and Taylor, {Sonja S} and Smyth, {Thomas J} and Anna Soler-Vila and Magee, {Pamela J} and Gill, {Chris I R} and Strain, {Conall R} and Vicky Hegan and Martin Devaney and Wallace, {Julie M W} and Paul Cherry and FitzGerald, {Richard J} and Strain, {J J} and O'Doherty, {John V} and McSorley, {Emeir M}",
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The effect of consuming Palmaria palmata-enriched bread on inflammatory markers, antioxidant status, lipid profile and thyroid function in a randomised placebo-controlled intervention trial in healthy adults. / Allsopp, Philip; Crowe, William; Bahar, Bojlul; Harnedy, Pádraigín A; Brown, Emma S; Taylor, Sonja S; Smyth, Thomas J; Soler-Vila, Anna; Magee, Pamela J; Gill, Chris I R; Strain, Conall R; Hegan, Vicky; Devaney, Martin; Wallace, Julie M W; Cherry, Paul; FitzGerald, Richard J; Strain, J J; O'Doherty, John V; McSorley, Emeir M.

In: European Journal of Nutrition, Vol. 55, No. 5, 31.07.2015, p. 1951-1962.

Research output: Contribution to journalArticle

TY - JOUR

T1 - The effect of consuming Palmaria palmata-enriched bread on inflammatory markers, antioxidant status, lipid profile and thyroid function in a randomised placebo-controlled intervention trial in healthy adults.

AU - Allsopp, Philip

AU - Crowe, William

AU - Bahar, Bojlul

AU - Harnedy, Pádraigín A

AU - Brown, Emma S

AU - Taylor, Sonja S

AU - Smyth, Thomas J

AU - Soler-Vila, Anna

AU - Magee, Pamela J

AU - Gill, Chris I R

AU - Strain, Conall R

AU - Hegan, Vicky

AU - Devaney, Martin

AU - Wallace, Julie M W

AU - Cherry, Paul

AU - FitzGerald, Richard J

AU - Strain, J J

AU - O'Doherty, John V

AU - McSorley, Emeir M

PY - 2015/7/31

Y1 - 2015/7/31

N2 - PURPOSEPalmaria palmata (P. Palmata) is reported to contain anti-inflammatory and antioxidant compounds albeit no study has investigated these effects in humans.METHODSA randomised parallel placebo-controlled human intervention study was carried out to investigate the effect of consuming P. Palmata (5 g/day) incorporated into a bread on serum markers of inflammation [C-reactive protein (CRP); cytokine analysis] with secondary analysis investigating changes in lipids (cholesterol, triglycerides), thyroid function [thyroid-stimulating hormone (TSH)] and antioxidant status ferric reducing antioxidant power. ANCOVA with baseline values as covariates, controlling for age, BMI, sex and smoking status, was used to compare differences between treatment groups over time . In vitro studies investigated the inflammatory activity of P. Palmata extracts (hot water, cold water and ethanol extract), protein extracts and associated protein hydrolysates using a Caco-2 inflammation cell model.RESULTSConsumption of P. Palmata-enriched bread significantly increased serum CRP (+16.1 %, P = 0.011), triglycerides (+31.9 %, P = 0.001) and TSH (+17.2 %, P = 0.017) when compared to the control group. In vitro evaluation of P. palmata extracts and protein hydrolysates identified a significant induction of IL-8 secretion by Caco-2 cells, and the hot water P. palmata extract was shown to increase adipocyte glycerol release (P <0.05).CONCLUSIONEvidence from this human study suggests that P. palmata stimulates inflammation, increases serum triglycerides and alters thyroid function; however, these changes are not likely to impact health as changes remained within the normal clinical range. The data from the in vitro study provided indications that IL-8 may contribute to the apparent immunostimulation noted in the human study.

AB - PURPOSEPalmaria palmata (P. Palmata) is reported to contain anti-inflammatory and antioxidant compounds albeit no study has investigated these effects in humans.METHODSA randomised parallel placebo-controlled human intervention study was carried out to investigate the effect of consuming P. Palmata (5 g/day) incorporated into a bread on serum markers of inflammation [C-reactive protein (CRP); cytokine analysis] with secondary analysis investigating changes in lipids (cholesterol, triglycerides), thyroid function [thyroid-stimulating hormone (TSH)] and antioxidant status ferric reducing antioxidant power. ANCOVA with baseline values as covariates, controlling for age, BMI, sex and smoking status, was used to compare differences between treatment groups over time . In vitro studies investigated the inflammatory activity of P. Palmata extracts (hot water, cold water and ethanol extract), protein extracts and associated protein hydrolysates using a Caco-2 inflammation cell model.RESULTSConsumption of P. Palmata-enriched bread significantly increased serum CRP (+16.1 %, P = 0.011), triglycerides (+31.9 %, P = 0.001) and TSH (+17.2 %, P = 0.017) when compared to the control group. In vitro evaluation of P. palmata extracts and protein hydrolysates identified a significant induction of IL-8 secretion by Caco-2 cells, and the hot water P. palmata extract was shown to increase adipocyte glycerol release (P <0.05).CONCLUSIONEvidence from this human study suggests that P. palmata stimulates inflammation, increases serum triglycerides and alters thyroid function; however, these changes are not likely to impact health as changes remained within the normal clinical range. The data from the in vitro study provided indications that IL-8 may contribute to the apparent immunostimulation noted in the human study.

KW - Palmaria palmata

KW - seaweed

KW - lipid

KW - inflammation

KW - human

U2 - 10.1007/s00394-015-1011-1

DO - 10.1007/s00394-015-1011-1

M3 - Article

VL - 55

SP - 1951

EP - 1962

JO - European Journal of Nutrition

T2 - European Journal of Nutrition

JF - European Journal of Nutrition

SN - 1436-6207

IS - 5

ER -