The effect of confounding data features on a deep learning algorithm to predict complete coronary occlusion in a retrospective observational setting

Rob Brisk, RR Bond, D Finlay, James McLaughlin, Alicja Jasinska-Piadlo, Stephen James Leslie, David E Gossman, Ian Menown, David J. McEneaney, Stafford Warren

Research output: Contribution to journalArticlepeer-review

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Abstract

Background: Deep learning (DL) has emerged in recent years as an effective technique in automated ECG analysis. Methods: A retrospective, observational study was design to assess the feasibility of detecting induced coronary artery occlusion in human subjects earlier than experienced cardiologists using a DL algorithm. A deep convolutional neural network (CNN) was trained using data from the STAFF III database. The task was to classify ECG samples as showing acute coronary artery occlusion, or no occlusion. Occluded samples were recorded after 60 seconds of balloon occlusion of a single coronary artery. For the first iteration of the experiment, non-occluded samples were taken from ECGs recorded in a rest room prior to entering theatres. For the second iteration of the experiment, non-occluded samples were taken in theatre prior to balloon inflation. Results were obtained using a cross-validation approach. Results: In the first iteration of the experiment, the DL model achieved an F1 score of 0.814, which was higher than any of three reviewing cardiologists or STEMI criteria. In the second iteration of the experiment, the DL model achieved an F1 score of 0.533, which is akin to the performance of a random chance classifier. Conclusion: The dataset was too small for the second model to achieve meaningful performance, despite the use of transfer learning. However, “data leakage” during the first iteration of the experiment led to falsely high results. This study highlights the risk of DL models leveraging data leaks to produce spurious results.
Original languageEnglish
Pages (from-to)1-8
Number of pages8
JournalEuropean Heart Journal Digital Health
DOIs
Publication statusPublished - 20 Feb 2021

Keywords

  • deep learning
  • data leakage
  • STEMI
  • heart attacks
  • acute myocardial infarction
  • cardiology
  • healthcare data science
  • diagnostic algorithms
  • decision support
  • confounding factors
  • curse of dimensionality

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