The effect of acute aerobic exercise on pulse wave velocity and oxidative stress following postprandial hypertriglyceridemia in healthy men

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Abstract

Oxidative stress is postulated to be responsible for the postprandial impairments in vascular function. The purpose of this study was to measure pulse wave velocity (PWV) and markers of postprandial oxidative stress before and after an acute bout of moderate exercise. Ten trained male subjects (age 21.5 ± 2.5 years, VO2 max 58.5 ±7.1 ml kg–1 min–1) participated in a randomised crossover design: (1) high-fat meal alone (2) high-fat meal followed 2 h later by a bout of 1 h moderate (60% max HR) exercise.PWV was examined at baseline, 1, 2, 3, and 4 h postprandially. Blood Lipid hydroperoxides (LOOHs), Superoxide dismutase (SOD) and other biochemicalmarkers were measured. PWV increased at 1 h (6.49 ± 2.1 m s–1), 2 h (6.94 ± 2.4 m s–1), 3 h (7.25 ± 2.1 m s–1) and 4 h (7.41 ± 2.5 m s–1) respectively, in the control trial(P <0.05). There was no change in PWV at 3 h (5.36 ± 1.1 m s–1) or 4 h (5.95 ± 2.3 m s–1) post ingestion in the exercise trial (P > 0.05). LOOH levels decreased at 3 hpost ingestion in the exercise trial compared to levels at 3 h (P <0.05) in the control trial. SOD levels were lower at 3 h post ingestion in the control trial compared to 3 h in theexercise trial (0.52 ± 0.05 vs. 0.41 ± 0.1 units ll–1; P <0.05). These findings suggest that a single session of aerobic exercise can ameliorate the postprandial impairmentsin arterial function by possibly reducing oxidative stress levels.
LanguageEnglish
Pages225-234
JournalEuropean Journal of Applied Physiology
Volume100
DOIs
Publication statusPublished - 7 Feb 2007

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Pulse Wave Analysis
Hypertriglyceridemia
Oxidative Stress
Exercise
Superoxide Dismutase
Meals
Eating
Fats
Lipid Peroxides
Cross-Over Studies
Blood Vessels

Keywords

  • Exercise
  • Postprandial lipaemia
  • Oxidative stress
  • Vascular function
  • Lipid
  • hydroperoxides

Cite this

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title = "The effect of acute aerobic exercise on pulse wave velocity and oxidative stress following postprandial hypertriglyceridemia in healthy men",
abstract = "Oxidative stress is postulated to be responsible for the postprandial impairments in vascular function. The purpose of this study was to measure pulse wave velocity (PWV) and markers of postprandial oxidative stress before and after an acute bout of moderate exercise. Ten trained male subjects (age 21.5 ± 2.5 years, VO2 max 58.5 ±7.1 ml kg–1 min–1) participated in a randomised crossover design: (1) high-fat meal alone (2) high-fat meal followed 2 h later by a bout of 1 h moderate (60{\%} max HR) exercise.PWV was examined at baseline, 1, 2, 3, and 4 h postprandially. Blood Lipid hydroperoxides (LOOHs), Superoxide dismutase (SOD) and other biochemicalmarkers were measured. PWV increased at 1 h (6.49 ± 2.1 m s–1), 2 h (6.94 ± 2.4 m s–1), 3 h (7.25 ± 2.1 m s–1) and 4 h (7.41 ± 2.5 m s–1) respectively, in the control trial(P <0.05). There was no change in PWV at 3 h (5.36 ± 1.1 m s–1) or 4 h (5.95 ± 2.3 m s–1) post ingestion in the exercise trial (P > 0.05). LOOH levels decreased at 3 hpost ingestion in the exercise trial compared to levels at 3 h (P <0.05) in the control trial. SOD levels were lower at 3 h post ingestion in the control trial compared to 3 h in theexercise trial (0.52 ± 0.05 vs. 0.41 ± 0.1 units ll–1; P <0.05). These findings suggest that a single session of aerobic exercise can ameliorate the postprandial impairmentsin arterial function by possibly reducing oxidative stress levels.",
keywords = "Exercise, Postprandial lipaemia, Oxidative stress, Vascular function, Lipid, hydroperoxides",
author = "Conor McClean and JAD McLaughlin and GA Burke and Marie Murphy and Tom Trinick and Ellie Duly and Gareth Davison",
year = "2007",
month = "2",
day = "7",
doi = "10.1007/s00421-007-0422-y",
language = "English",
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pages = "225--234",
journal = "European Journal of Applied Physiology",
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T1 - The effect of acute aerobic exercise on pulse wave velocity and oxidative stress following postprandial hypertriglyceridemia in healthy men

AU - McClean, Conor

AU - McLaughlin, JAD

AU - Burke, GA

AU - Murphy, Marie

AU - Trinick, Tom

AU - Duly, Ellie

AU - Davison, Gareth

PY - 2007/2/7

Y1 - 2007/2/7

N2 - Oxidative stress is postulated to be responsible for the postprandial impairments in vascular function. The purpose of this study was to measure pulse wave velocity (PWV) and markers of postprandial oxidative stress before and after an acute bout of moderate exercise. Ten trained male subjects (age 21.5 ± 2.5 years, VO2 max 58.5 ±7.1 ml kg–1 min–1) participated in a randomised crossover design: (1) high-fat meal alone (2) high-fat meal followed 2 h later by a bout of 1 h moderate (60% max HR) exercise.PWV was examined at baseline, 1, 2, 3, and 4 h postprandially. Blood Lipid hydroperoxides (LOOHs), Superoxide dismutase (SOD) and other biochemicalmarkers were measured. PWV increased at 1 h (6.49 ± 2.1 m s–1), 2 h (6.94 ± 2.4 m s–1), 3 h (7.25 ± 2.1 m s–1) and 4 h (7.41 ± 2.5 m s–1) respectively, in the control trial(P <0.05). There was no change in PWV at 3 h (5.36 ± 1.1 m s–1) or 4 h (5.95 ± 2.3 m s–1) post ingestion in the exercise trial (P > 0.05). LOOH levels decreased at 3 hpost ingestion in the exercise trial compared to levels at 3 h (P <0.05) in the control trial. SOD levels were lower at 3 h post ingestion in the control trial compared to 3 h in theexercise trial (0.52 ± 0.05 vs. 0.41 ± 0.1 units ll–1; P <0.05). These findings suggest that a single session of aerobic exercise can ameliorate the postprandial impairmentsin arterial function by possibly reducing oxidative stress levels.

AB - Oxidative stress is postulated to be responsible for the postprandial impairments in vascular function. The purpose of this study was to measure pulse wave velocity (PWV) and markers of postprandial oxidative stress before and after an acute bout of moderate exercise. Ten trained male subjects (age 21.5 ± 2.5 years, VO2 max 58.5 ±7.1 ml kg–1 min–1) participated in a randomised crossover design: (1) high-fat meal alone (2) high-fat meal followed 2 h later by a bout of 1 h moderate (60% max HR) exercise.PWV was examined at baseline, 1, 2, 3, and 4 h postprandially. Blood Lipid hydroperoxides (LOOHs), Superoxide dismutase (SOD) and other biochemicalmarkers were measured. PWV increased at 1 h (6.49 ± 2.1 m s–1), 2 h (6.94 ± 2.4 m s–1), 3 h (7.25 ± 2.1 m s–1) and 4 h (7.41 ± 2.5 m s–1) respectively, in the control trial(P <0.05). There was no change in PWV at 3 h (5.36 ± 1.1 m s–1) or 4 h (5.95 ± 2.3 m s–1) post ingestion in the exercise trial (P > 0.05). LOOH levels decreased at 3 hpost ingestion in the exercise trial compared to levels at 3 h (P <0.05) in the control trial. SOD levels were lower at 3 h post ingestion in the control trial compared to 3 h in theexercise trial (0.52 ± 0.05 vs. 0.41 ± 0.1 units ll–1; P <0.05). These findings suggest that a single session of aerobic exercise can ameliorate the postprandial impairmentsin arterial function by possibly reducing oxidative stress levels.

KW - Exercise

KW - Postprandial lipaemia

KW - Oxidative stress

KW - Vascular function

KW - Lipid

KW - hydroperoxides

U2 - 10.1007/s00421-007-0422-y

DO - 10.1007/s00421-007-0422-y

M3 - Article

VL - 100

SP - 225

EP - 234

JO - European Journal of Applied Physiology

T2 - European Journal of Applied Physiology

JF - European Journal of Applied Physiology

SN - 1439-6319

ER -