The Development of Sustained Release Drug Delivery Platforms using Melt-Extruded Cellulose Polymer Blends

Matthew Wilson, David Jones, Gavin P Andrews

Research output: Contribution to journalArticle

4 Citations (Scopus)

Abstract

Objectives
This research examined the application of hot melt extrusion (HME) in the preparation of matrix formulations containing hydroxypropyl cellulose (HPC) as a base polymer in combination with methyl cellulose (MC) and hydroxypropyl methylcellulose (HPMC).

Methods
The limit to which formulations could control drug release under varying paddle speeds, high alcohol environments and high and low drug loads was investigated on a Caleva 10 ST dissolution tester. Rheological studies and hot plate imaging highlighted the impact of thermoresponsive polymers on drug release. The rate and percentage release of drug were analysed using a one‐way ANOVA and Tukey's HSD test.

Key findings
No significant differences in the amount of drug released were calculated as a result of paddle speed variation or in the presence of 40% v/v ETOH. The phase separation effects of temperature‐sensitive polymers HPC and MC and the characteristic gel shrinkage and fluid expulsion were shown to be contributing factors. The use of the partition activity, α, identified the extent to which formulations were affected by phase separation.

Conclusion
Hot melt extrusion was successfully used to manufacture cellulose‐based formulations. Thermoresponsive polymers HPC and MC significantly impacted drug release properties.
LanguageEnglish
Pages32-42
Number of pages11
JournalJOURNAL OF PHARMACY AND PHARMACOLOGY
Volume69
Issue number1
Early online date17 Oct 2016
DOIs
Publication statusPublished - Jan 2017

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Cellulose
Methylcellulose
Polymers
Pharmaceutical Preparations
Analysis of Variance
Gels
Alcohols
Temperature
Drug Liberation
Research
hydroxypropylcellulose

Keywords

  • controlled release
  • hot melt extrusion
  • hydroxypropyl cellulose
  • low critical solution temperature
  • phase separation

Cite this

Wilson, Matthew ; Jones, David ; Andrews, Gavin P. / The Development of Sustained Release Drug Delivery Platforms using Melt-Extruded Cellulose Polymer Blends. In: JOURNAL OF PHARMACY AND PHARMACOLOGY. 2017 ; Vol. 69, No. 1. pp. 32-42.
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abstract = "ObjectivesThis research examined the application of hot melt extrusion (HME) in the preparation of matrix formulations containing hydroxypropyl cellulose (HPC) as a base polymer in combination with methyl cellulose (MC) and hydroxypropyl methylcellulose (HPMC).MethodsThe limit to which formulations could control drug release under varying paddle speeds, high alcohol environments and high and low drug loads was investigated on a Caleva 10 ST dissolution tester. Rheological studies and hot plate imaging highlighted the impact of thermoresponsive polymers on drug release. The rate and percentage release of drug were analysed using a one‐way ANOVA and Tukey's HSD test.Key findingsNo significant differences in the amount of drug released were calculated as a result of paddle speed variation or in the presence of 40{\%} v/v ETOH. The phase separation effects of temperature‐sensitive polymers HPC and MC and the characteristic gel shrinkage and fluid expulsion were shown to be contributing factors. The use of the partition activity, α, identified the extent to which formulations were affected by phase separation.ConclusionHot melt extrusion was successfully used to manufacture cellulose‐based formulations. Thermoresponsive polymers HPC and MC significantly impacted drug release properties.",
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The Development of Sustained Release Drug Delivery Platforms using Melt-Extruded Cellulose Polymer Blends. / Wilson, Matthew; Jones, David; Andrews, Gavin P.

In: JOURNAL OF PHARMACY AND PHARMACOLOGY, Vol. 69, No. 1, 01.2017, p. 32-42.

Research output: Contribution to journalArticle

TY - JOUR

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AU - Wilson, Matthew

AU - Jones, David

AU - Andrews, Gavin P

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N2 - ObjectivesThis research examined the application of hot melt extrusion (HME) in the preparation of matrix formulations containing hydroxypropyl cellulose (HPC) as a base polymer in combination with methyl cellulose (MC) and hydroxypropyl methylcellulose (HPMC).MethodsThe limit to which formulations could control drug release under varying paddle speeds, high alcohol environments and high and low drug loads was investigated on a Caleva 10 ST dissolution tester. Rheological studies and hot plate imaging highlighted the impact of thermoresponsive polymers on drug release. The rate and percentage release of drug were analysed using a one‐way ANOVA and Tukey's HSD test.Key findingsNo significant differences in the amount of drug released were calculated as a result of paddle speed variation or in the presence of 40% v/v ETOH. The phase separation effects of temperature‐sensitive polymers HPC and MC and the characteristic gel shrinkage and fluid expulsion were shown to be contributing factors. The use of the partition activity, α, identified the extent to which formulations were affected by phase separation.ConclusionHot melt extrusion was successfully used to manufacture cellulose‐based formulations. Thermoresponsive polymers HPC and MC significantly impacted drug release properties.

AB - ObjectivesThis research examined the application of hot melt extrusion (HME) in the preparation of matrix formulations containing hydroxypropyl cellulose (HPC) as a base polymer in combination with methyl cellulose (MC) and hydroxypropyl methylcellulose (HPMC).MethodsThe limit to which formulations could control drug release under varying paddle speeds, high alcohol environments and high and low drug loads was investigated on a Caleva 10 ST dissolution tester. Rheological studies and hot plate imaging highlighted the impact of thermoresponsive polymers on drug release. The rate and percentage release of drug were analysed using a one‐way ANOVA and Tukey's HSD test.Key findingsNo significant differences in the amount of drug released were calculated as a result of paddle speed variation or in the presence of 40% v/v ETOH. The phase separation effects of temperature‐sensitive polymers HPC and MC and the characteristic gel shrinkage and fluid expulsion were shown to be contributing factors. The use of the partition activity, α, identified the extent to which formulations were affected by phase separation.ConclusionHot melt extrusion was successfully used to manufacture cellulose‐based formulations. Thermoresponsive polymers HPC and MC significantly impacted drug release properties.

KW - controlled release

KW - hot melt extrusion

KW - hydroxypropyl cellulose

KW - low critical solution temperature

KW - phase separation

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DO - 10.1111/jphp.12656

M3 - Article

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