The design and progress of a multidomain lifestyle intervention to improve brain health in middle-aged persons to reduce later Alzheimer's disease risk: The Gray Matters randomized trial

Maria C. Norton; Christine J. Clark; JoAnn T. Tschanz; Phillip Hartin; Elizabeth B. Fauth; Julie A. Gast; Travis E. Dorsch; Heidi Wengreen; Chris Nugent; W. David Robinson; Michael Lefevre; S McClean; I. Cleland; Sydney Y. Schaefer; Sheryl Aguilar

doi:10.1016/j.trci.2015.05.001

The design and progress of a multidomain lifestyle intervention to improve brain health in middle-aged persons to reduce later Alzheimer's disease risk: The Gray Matters randomized trial

Maria C. Norton, Christine J. Clark, JoAnn T. Tschanz, Phillip Hartin, Elizabeth B. Fauth, Julie A. Gast, Travis E. Dorsch, Heidi Wengreen, Chris Nugent, W. David Robinson, Michael Lefevre, S McClean, I. Cleland, Sydney Y. Schaefer, Sheryl Aguilar

Vice President for Research seed grant, Utah State University

Research output: Contribution to journal › Article › peer-review

15 Citations (Scopus)

Abstract

ntroductionMost Alzheimer's disease (AD) prevention studies focus on older adults or persons with existing cognitive impairment. This study describes the design and progress of a novel pilot intervention, the Gray Matters study.MethodsThis proof-of-concept randomized controlled trial tests an evidence-based multidomain lifestyle intervention in 146 persons aged 40 to 64 years, in northern Utah. Data collectors were blinded to participants' randomization to treatment (n = 104) or control (n = 42). Intervention targeted physical activity, food choices, social engagement, cognitive simulation, sleep quality, and stress management, and uses a custom smartphone application, activity monitor, and educational materials. Secondary outcomes include biomarkers, body mass index, cognitive testing, and psychological surveys.ResultsMidway through the study, achievements include a 98.7% retention rate, a 96% rate of compliance with app data entry, and positive trends in behavioral change.DiscussionParticipants were empowered, learning that lifestyle might impact AD risk, exhibiting positive behavioral changes thus far.

Original language	English
Pages (from-to)	53-62
Journal	Alzheimer's and Dementia: Translational Research and Clinical Interventions
Volume	1
Issue number	1
DOIs	https://doi.org/10.1016/j.trci.2015.05.001
Publication status	Published (in print/issue) - 16 May 2015

Keywords

Lifestyle behavioral intervention
Randomized controlled trial
Middle age
Multidomain
Technology

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

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10.1016/j.trci.2015.05.001

Cite this

Norton, M. C., Clark, C. J., Tschanz, J. T., Hartin, P., Fauth, E. B., Gast, J. A., Dorsch, T. E., Wengreen, H., Nugent, C., Robinson, W. D., Lefevre, M., McClean, S., Cleland, I., Schaefer, S. Y., & Aguilar, S. (2015). The design and progress of a multidomain lifestyle intervention to improve brain health in middle-aged persons to reduce later Alzheimer's disease risk: The Gray Matters randomized trial. Alzheimer's and Dementia: Translational Research and Clinical Interventions, 1(1), 53-62. https://doi.org/10.1016/j.trci.2015.05.001

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title = "The design and progress of a multidomain lifestyle intervention to improve brain health in middle-aged persons to reduce later Alzheimer's disease risk: The Gray Matters randomized trial",

abstract = "ntroductionMost Alzheimer's disease (AD) prevention studies focus on older adults or persons with existing cognitive impairment. This study describes the design and progress of a novel pilot intervention, the Gray Matters study.MethodsThis proof-of-concept randomized controlled trial tests an evidence-based multidomain lifestyle intervention in 146 persons aged 40 to 64 years, in northern Utah. Data collectors were blinded to participants' randomization to treatment (n = 104) or control (n = 42). Intervention targeted physical activity, food choices, social engagement, cognitive simulation, sleep quality, and stress management, and uses a custom smartphone application, activity monitor, and educational materials. Secondary outcomes include biomarkers, body mass index, cognitive testing, and psychological surveys.ResultsMidway through the study, achievements include a 98.7\% retention rate, a 96\% rate of compliance with app data entry, and positive trends in behavioral change.DiscussionParticipants were empowered, learning that lifestyle might impact AD risk, exhibiting positive behavioral changes thus far.",

keywords = "Lifestyle behavioral intervention, Randomized controlled trial, Middle age, Multidomain, Technology",

author = "Norton, \{Maria C.\} and Clark, \{Christine J.\} and Tschanz, \{JoAnn T.\} and Phillip Hartin and Fauth, \{Elizabeth B.\} and Gast, \{Julie A.\} and Dorsch, \{Travis E.\} and Heidi Wengreen and Chris Nugent and Robinson, \{W. David\} and Michael Lefevre and S McClean and I. Cleland and Schaefer, \{Sydney Y.\} and Sheryl Aguilar",

year = "2015",

month = may,

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doi = "10.1016/j.trci.2015.05.001",

language = "English",

volume = "1",

pages = "53--62",

journal = "Alzheimer's and Dementia: Translational Research and Clinical Interventions",

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Norton, MC, Clark, CJ, Tschanz, JT, Hartin, P, Fauth, EB, Gast, JA, Dorsch, TE, Wengreen, H, Nugent, C, Robinson, WD, Lefevre, M, McClean, S , Cleland, I, Schaefer, SY & Aguilar, S 2015, 'The design and progress of a multidomain lifestyle intervention to improve brain health in middle-aged persons to reduce later Alzheimer's disease risk: The Gray Matters randomized trial', Alzheimer's and Dementia: Translational Research and Clinical Interventions, vol. 1, no. 1, pp. 53-62. https://doi.org/10.1016/j.trci.2015.05.001

The design and progress of a multidomain lifestyle intervention to improve brain health in middle-aged persons to reduce later Alzheimer's disease risk: The Gray Matters randomized trial. / Norton, Maria C.; Clark, Christine J.; Tschanz, JoAnn T. et al.
In: Alzheimer's and Dementia: Translational Research and Clinical Interventions, Vol. 1, No. 1, 16.05.2015, p. 53-62.

Research output: Contribution to journal › Article › peer-review

TY - JOUR

T1 - The design and progress of a multidomain lifestyle intervention to improve brain health in middle-aged persons to reduce later Alzheimer's disease risk: The Gray Matters randomized trial

AU - Norton, Maria C.

AU - Clark, Christine J.

AU - Tschanz, JoAnn T.

AU - Hartin, Phillip

AU - Fauth, Elizabeth B.

AU - Gast, Julie A.

AU - Dorsch, Travis E.

AU - Wengreen, Heidi

AU - Nugent, Chris

AU - Robinson, W. David

AU - Lefevre, Michael

AU - McClean, S

AU - Cleland, I.

AU - Schaefer, Sydney Y.

AU - Aguilar, Sheryl

PY - 2015/5/16

Y1 - 2015/5/16

N2 - ntroductionMost Alzheimer's disease (AD) prevention studies focus on older adults or persons with existing cognitive impairment. This study describes the design and progress of a novel pilot intervention, the Gray Matters study.MethodsThis proof-of-concept randomized controlled trial tests an evidence-based multidomain lifestyle intervention in 146 persons aged 40 to 64 years, in northern Utah. Data collectors were blinded to participants' randomization to treatment (n = 104) or control (n = 42). Intervention targeted physical activity, food choices, social engagement, cognitive simulation, sleep quality, and stress management, and uses a custom smartphone application, activity monitor, and educational materials. Secondary outcomes include biomarkers, body mass index, cognitive testing, and psychological surveys.ResultsMidway through the study, achievements include a 98.7% retention rate, a 96% rate of compliance with app data entry, and positive trends in behavioral change.DiscussionParticipants were empowered, learning that lifestyle might impact AD risk, exhibiting positive behavioral changes thus far.

AB - ntroductionMost Alzheimer's disease (AD) prevention studies focus on older adults or persons with existing cognitive impairment. This study describes the design and progress of a novel pilot intervention, the Gray Matters study.MethodsThis proof-of-concept randomized controlled trial tests an evidence-based multidomain lifestyle intervention in 146 persons aged 40 to 64 years, in northern Utah. Data collectors were blinded to participants' randomization to treatment (n = 104) or control (n = 42). Intervention targeted physical activity, food choices, social engagement, cognitive simulation, sleep quality, and stress management, and uses a custom smartphone application, activity monitor, and educational materials. Secondary outcomes include biomarkers, body mass index, cognitive testing, and psychological surveys.ResultsMidway through the study, achievements include a 98.7% retention rate, a 96% rate of compliance with app data entry, and positive trends in behavioral change.DiscussionParticipants were empowered, learning that lifestyle might impact AD risk, exhibiting positive behavioral changes thus far.

KW - Lifestyle behavioral intervention

KW - Randomized controlled trial

KW - Middle age

KW - Multidomain

KW - Technology

UR - https://pure.ulster.ac.uk/en/publications/the-design-and-progress-of-a-multidomain-lifestyle-intervention-t-3

UR - https://www.scopus.com/pages/publications/84944049002

U2 - 10.1016/j.trci.2015.05.001

DO - 10.1016/j.trci.2015.05.001

M3 - Article

SN - 2352-8737

VL - 1

SP - 53

EP - 62

JO - Alzheimer's and Dementia: Translational Research and Clinical Interventions

JF - Alzheimer's and Dementia: Translational Research and Clinical Interventions

IS - 1

ER -

Norton MC, Clark CJ, Tschanz JT, Hartin P, Fauth EB, Gast JA et al. The design and progress of a multidomain lifestyle intervention to improve brain health in middle-aged persons to reduce later Alzheimer's disease risk: The Gray Matters randomized trial. Alzheimer's and Dementia: Translational Research and Clinical Interventions. 2015 May 16;1(1):53-62. doi: 10.1016/j.trci.2015.05.001

The design and progress of a multidomain lifestyle intervention to improve brain health in middle-aged persons to reduce later Alzheimer's disease risk: The Gray Matters randomized trial

Abstract

Keywords

UN SDGs

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Ian Cleland

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The design and progress of a multidomain lifestyle intervention to improve brain health in middle-aged persons to reduce later Alzheimer's disease risk: The Gray Matters randomized trial

Abstract

Keywords

UN SDGs

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Ian Cleland

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