TY - JOUR
T1 - The design and progress of a multidomain lifestyle intervention to improve brain health in middle-aged persons to reduce later Alzheimer's disease risk: The Gray Matters randomized trial
AU - Norton, Maria C.
AU - Clark, Christine J.
AU - Tschanz, JoAnn T.
AU - Hartin, Phillip
AU - Fauth, Elizabeth B.
AU - Gast, Julie A.
AU - Dorsch, Travis E.
AU - Wengreen, Heidi
AU - Nugent, Chris
AU - Robinson, W. David
AU - Lefevre, Michael
AU - McClean, S
AU - Cleland, I.
AU - Schaefer, Sydney Y.
AU - Aguilar, Sheryl
PY - 2015/5/16
Y1 - 2015/5/16
N2 - ntroductionMost Alzheimer's disease (AD) prevention studies focus on older adults or persons with existing cognitive impairment. This study describes the design and progress of a novel pilot intervention, the Gray Matters study.MethodsThis proof-of-concept randomized controlled trial tests an evidence-based multidomain lifestyle intervention in 146 persons aged 40 to 64 years, in northern Utah. Data collectors were blinded to participants' randomization to treatment (n = 104) or control (n = 42). Intervention targeted physical activity, food choices, social engagement, cognitive simulation, sleep quality, and stress management, and uses a custom smartphone application, activity monitor, and educational materials. Secondary outcomes include biomarkers, body mass index, cognitive testing, and psychological surveys.ResultsMidway through the study, achievements include a 98.7% retention rate, a 96% rate of compliance with app data entry, and positive trends in behavioral change.DiscussionParticipants were empowered, learning that lifestyle might impact AD risk, exhibiting positive behavioral changes thus far.
AB - ntroductionMost Alzheimer's disease (AD) prevention studies focus on older adults or persons with existing cognitive impairment. This study describes the design and progress of a novel pilot intervention, the Gray Matters study.MethodsThis proof-of-concept randomized controlled trial tests an evidence-based multidomain lifestyle intervention in 146 persons aged 40 to 64 years, in northern Utah. Data collectors were blinded to participants' randomization to treatment (n = 104) or control (n = 42). Intervention targeted physical activity, food choices, social engagement, cognitive simulation, sleep quality, and stress management, and uses a custom smartphone application, activity monitor, and educational materials. Secondary outcomes include biomarkers, body mass index, cognitive testing, and psychological surveys.ResultsMidway through the study, achievements include a 98.7% retention rate, a 96% rate of compliance with app data entry, and positive trends in behavioral change.DiscussionParticipants were empowered, learning that lifestyle might impact AD risk, exhibiting positive behavioral changes thus far.
KW - Lifestyle behavioral intervention
KW - Randomized controlled trial
KW - Middle age
KW - Multidomain
KW - Technology
UR - https://pure.ulster.ac.uk/en/publications/the-design-and-progress-of-a-multidomain-lifestyle-intervention-t-3
U2 - 10.1016/j.trci.2015.05.001
DO - 10.1016/j.trci.2015.05.001
M3 - Article
SN - 2352-8737
VL - 1
SP - 53
EP - 62
JO - Alzheimer's and Dementia: Translational Research and Clinical Interventions
JF - Alzheimer's and Dementia: Translational Research and Clinical Interventions
IS - 1
ER -
