The changing epidemiology of Ebstein's anomaly and its relationship to maternal mental health conditions: a European registry-based study

Breidge Boyle, Ester Garne, Maria Loane, Marie-Claude Addor, Larraitz Arriola, Clara Cavero-Carbonell, Hermien de Walle, Miriam Gatte, Nathalie Lelong, Catherine Lynch, Vera Nelen, Amanda Neville, Mary O'Mahony, Anna Pierini, Anke Rissmann, David Tucker, Natalia Zymak-Zakutnia, Helen Dolk

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Abstract

Objectives: To describe the epidemiology of Ebstein’s anomaly in Europe and its association with maternal health and medication exposure during pregnancy. Design: Descriptive epidemiologic analysis of population-based data Setting: 15 EUROCAT Congenital Anomaly Registries in 12 European countries: population 5.6 million births 1982-2011. Participants: Cases included livebirths, fetal deaths from 20 weeks gestation, and terminations of pregnancy for fetal anomaly. Main outcome measures: Total prevalence per 10,000 births. Odds ratios for exposure to maternal illnesses / medications in the first trimester of pregnancy were calculated by comparing Ebstein’s anomaly cases to cardiac and non-cardiac malformed controls, excluding genetic syndromes; adjusted for time period and country.Results: 264 Ebstein’s anomaly cases were recorded; 81% were livebirths, 2% of which were diagnosed after the first year of life. 54% of cases Ebstein’s anomaly or a co-existing congenital anomaly was prenatally diagnosed. Total Prevalence rose over time from 0.29 (95%CI 0.20-0.41 to 0.48 (95%CI 0.40-0.57) (p
Original languageEnglish
Pages (from-to)677-685
JournalCardiology in the Young
Volume27
Issue number4
Early online date30 Aug 2016
DOIs
Publication statusPublished - May 2017

Keywords

  • Ebstein’s anomaly
  • Prevalence
  • Antidepressants
  • Psycholeptics
  • Mental illness

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    Boyle, B., Garne, E., Loane, M., Addor, M-C., Arriola, L., Cavero-Carbonell, C., de Walle, H., Gatte, M., Lelong, N., Lynch, C., Nelen, V., Neville, A., O'Mahony, M., Pierini, A., Rissmann, A., Tucker, D., Zymak-Zakutnia, N., & Dolk, H. (2017). The changing epidemiology of Ebstein's anomaly and its relationship to maternal mental health conditions: a European registry-based study. Cardiology in the Young, 27(4), 677-685. https://doi.org/10.1017/S1047951116001025