The changing epidemiology of Ebstein's anomaly and its relationship to maternal mental health conditions: a European registry-based study

Breidge Boyle, Ester Garne, Maria Loane, Marie-Claude Addor, Larraitz Arriola, Clara Cavero-Carbonell, Hermien de Walle, Miriam Gatte, Nathalie Lelong, Catherine Lynch, Vera Nelen, Amanda Neville, Mary O'Mahony, Anna Pierini, Anke Rissmann, David Tucker, Natalia Zymak-Zakutnia, Helen Dolk

Research output: Contribution to journalArticle

5 Citations (Scopus)

Abstract

Objectives: To describe the epidemiology of Ebstein’s anomaly in Europe and its association with maternal health and medication exposure during pregnancy. Design: Descriptive epidemiologic analysis of population-based data Setting: 15 EUROCAT Congenital Anomaly Registries in 12 European countries: population 5.6 million births 1982-2011. Participants: Cases included livebirths, fetal deaths from 20 weeks gestation, and terminations of pregnancy for fetal anomaly. Main outcome measures: Total prevalence per 10,000 births. Odds ratios for exposure to maternal illnesses / medications in the first trimester of pregnancy were calculated by comparing Ebstein’s anomaly cases to cardiac and non-cardiac malformed controls, excluding genetic syndromes; adjusted for time period and country.Results: 264 Ebstein’s anomaly cases were recorded; 81% were livebirths, 2% of which were diagnosed after the first year of life. 54% of cases Ebstein’s anomaly or a co-existing congenital anomaly was prenatally diagnosed. Total Prevalence rose over time from 0.29 (95%CI 0.20-0.41 to 0.48 (95%CI 0.40-0.57) (p
LanguageEnglish
Pages677-685
JournalCardiology in the Young
Volume27
Issue number4
Early online date30 Aug 2016
DOIs
Publication statusPublished - May 2017

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Ebstein Anomaly
Registries
Mental Health
Epidemiology
Pregnancy
Parturition
Maternal Exposure
Fetal Death
First Pregnancy Trimester
Population
Odds Ratio
Outcome Assessment (Health Care)
Maternal Health

Keywords

  • Ebstein’s anomaly
  • Prevalence
  • Antidepressants
  • Psycholeptics
  • Mental illness

Cite this

Boyle, Breidge ; Garne, Ester ; Loane, Maria ; Addor, Marie-Claude ; Arriola, Larraitz ; Cavero-Carbonell, Clara ; de Walle, Hermien ; Gatte, Miriam ; Lelong, Nathalie ; Lynch, Catherine ; Nelen, Vera ; Neville, Amanda ; O'Mahony, Mary ; Pierini, Anna ; Rissmann, Anke ; Tucker, David ; Zymak-Zakutnia, Natalia ; Dolk, Helen. / The changing epidemiology of Ebstein's anomaly and its relationship to maternal mental health conditions: a European registry-based study. In: Cardiology in the Young. 2017 ; Vol. 27, No. 4. pp. 677-685.
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Boyle, B, Garne, E, Loane, M, Addor, M-C, Arriola, L, Cavero-Carbonell, C, de Walle, H, Gatte, M, Lelong, N, Lynch, C, Nelen, V, Neville, A, O'Mahony, M, Pierini, A, Rissmann, A, Tucker, D, Zymak-Zakutnia, N & Dolk, H 2017, 'The changing epidemiology of Ebstein's anomaly and its relationship to maternal mental health conditions: a European registry-based study', Cardiology in the Young, vol. 27, no. 4, pp. 677-685. https://doi.org/10.1017/S1047951116001025

The changing epidemiology of Ebstein's anomaly and its relationship to maternal mental health conditions: a European registry-based study. / Boyle, Breidge; Garne, Ester; Loane, Maria; Addor, Marie-Claude; Arriola, Larraitz; Cavero-Carbonell, Clara; de Walle, Hermien; Gatte, Miriam; Lelong, Nathalie; Lynch, Catherine; Nelen, Vera; Neville, Amanda; O'Mahony, Mary; Pierini, Anna; Rissmann, Anke; Tucker, David; Zymak-Zakutnia, Natalia; Dolk, Helen.

In: Cardiology in the Young, Vol. 27, No. 4, 05.2017, p. 677-685.

Research output: Contribution to journalArticle

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AU - Boyle, Breidge

AU - Garne, Ester

AU - Loane, Maria

AU - Addor, Marie-Claude

AU - Arriola, Larraitz

AU - Cavero-Carbonell, Clara

AU - de Walle, Hermien

AU - Gatte, Miriam

AU - Lelong, Nathalie

AU - Lynch, Catherine

AU - Nelen, Vera

AU - Neville, Amanda

AU - O'Mahony, Mary

AU - Pierini, Anna

AU - Rissmann, Anke

AU - Tucker, David

AU - Zymak-Zakutnia, Natalia

AU - Dolk, Helen

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N2 - Objectives: To describe the epidemiology of Ebstein’s anomaly in Europe and its association with maternal health and medication exposure during pregnancy. Design: Descriptive epidemiologic analysis of population-based data Setting: 15 EUROCAT Congenital Anomaly Registries in 12 European countries: population 5.6 million births 1982-2011. Participants: Cases included livebirths, fetal deaths from 20 weeks gestation, and terminations of pregnancy for fetal anomaly. Main outcome measures: Total prevalence per 10,000 births. Odds ratios for exposure to maternal illnesses / medications in the first trimester of pregnancy were calculated by comparing Ebstein’s anomaly cases to cardiac and non-cardiac malformed controls, excluding genetic syndromes; adjusted for time period and country.Results: 264 Ebstein’s anomaly cases were recorded; 81% were livebirths, 2% of which were diagnosed after the first year of life. 54% of cases Ebstein’s anomaly or a co-existing congenital anomaly was prenatally diagnosed. Total Prevalence rose over time from 0.29 (95%CI 0.20-0.41 to 0.48 (95%CI 0.40-0.57) (p

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