The associations of earlier trauma exposures and history of mental disorders with PTSD after subsequent traumas

RC Kessler, S Aguilar-Gaxiola, J Alonso, E. J. Bromet, O Gureje, EG Karam, K Koenen, S. Lee, H Liu, BE Pennell, MV Petukhova, N.A Sampson, V. Shahly, DJ Stein, Lukoye Atwoli, G Borges, B Bunting, G. de Girolamo, SF Gluzman, J. M. Haro & 11 others H Hinkov, N Kawakami, V Kovess-Masfety, F Navarro-Mateu, J Posada-Villa, KM Scott, AY Shalev, M. Ten Have, Y Torres, M.C Viana, AM Zaslavsky

Research output: Contribution to journalArticle

8 Citations (Scopus)

Abstract

Although earlier trauma exposure is known to predict posttraumatic stress disorder (PTSD) after subsequent traumas, it is unclear whether this association is limited to cases where the earlier trauma led to PTSD. Resolution of this uncertainty has important implications for research on pretrauma vulnerability to PTSD. We examined this issue in the World Health Organization (WHO) World Mental Health (WMH) Surveys with 34 676 respondents who reported lifetime trauma exposure. One lifetime trauma was selected randomly for each respondent. DSM-IV (Diagnostic and Statistical Manual of Mental Disorders, 4th Edition) PTSD due to that trauma was assessed. We reported in a previous paper that four earlier traumas involving interpersonal violence significantly predicted PTSD after subsequent random traumas (odds ratio (OR)=1.3–2.5). We also assessed 14 lifetime DSM-IV mood, anxiety, disruptive behavior and substance disorders before random traumas. We show in the current report that only prior anxiety disorders significantly predicted PTSD in a multivariate model (OR=1.5–4.3) and that these disorders interacted significantly with three of the earlier traumas (witnessing atrocities, physical violence victimization and rape). History of witnessing atrocities significantly predicted PTSD after subsequent random traumas only among respondents with prior PTSD (OR=5.6). Histories of physical violence victimization (OR=1.5) and rape after age 17 years (OR=17.6) significantly predicted only among respondents with no history of prior anxiety disorders. Although only preliminary due to reliance on retrospective reports, these results suggest that history of anxiety disorders and history of a limited number of earlier traumas might usefully be targeted in future prospective studies as distinct foci of research on individual differences in vulnerability to PTSD after subsequent traumas.
LanguageEnglish
Pages1892-1899
JournalMolecular Psychiatry
Volume23
Early online date19 Sep 2017
DOIs
Publication statusPublished - Sep 2018

Fingerprint

Post-Traumatic Stress Disorders
Mental Disorders
Wounds and Injuries
Odds Ratio
Anxiety Disorders
Violence
Diagnostic and Statistical Manual of Mental Disorders
Crime Victims
Rape
Attention Deficit and Disruptive Behavior Disorders
Health Surveys
Research
Individuality
Uncertainty
Mental Health
Anxiety
Prospective Studies

Cite this

Kessler, RC., Aguilar-Gaxiola, S., Alonso, J., Bromet, E. J., Gureje, O., Karam, EG., ... Zaslavsky, AM. (2018). The associations of earlier trauma exposures and history of mental disorders with PTSD after subsequent traumas. Molecular Psychiatry, 23, 1892-1899. https://doi.org/10.1038/mp.2017.194
Kessler, RC ; Aguilar-Gaxiola, S ; Alonso, J ; Bromet, E. J. ; Gureje, O ; Karam, EG ; Koenen, K ; Lee, S. ; Liu, H ; Pennell, BE ; Petukhova, MV ; Sampson, N.A ; Shahly, V. ; Stein, DJ ; Atwoli, Lukoye ; Borges, G ; Bunting, B ; de Girolamo, G. ; Gluzman, SF ; Haro, J. M. ; Hinkov, H ; Kawakami, N ; Kovess-Masfety, V ; Navarro-Mateu, F ; Posada-Villa, J ; Scott, KM ; Shalev, AY ; Ten Have, M. ; Torres, Y ; Viana, M.C ; Zaslavsky, AM. / The associations of earlier trauma exposures and history of mental disorders with PTSD after subsequent traumas. In: Molecular Psychiatry. 2018 ; Vol. 23. pp. 1892-1899.
@article{ddaee65bc2c14f2e80b00c16fc39d37c,
title = "The associations of earlier trauma exposures and history of mental disorders with PTSD after subsequent traumas",
abstract = "Although earlier trauma exposure is known to predict posttraumatic stress disorder (PTSD) after subsequent traumas, it is unclear whether this association is limited to cases where the earlier trauma led to PTSD. Resolution of this uncertainty has important implications for research on pretrauma vulnerability to PTSD. We examined this issue in the World Health Organization (WHO) World Mental Health (WMH) Surveys with 34 676 respondents who reported lifetime trauma exposure. One lifetime trauma was selected randomly for each respondent. DSM-IV (Diagnostic and Statistical Manual of Mental Disorders, 4th Edition) PTSD due to that trauma was assessed. We reported in a previous paper that four earlier traumas involving interpersonal violence significantly predicted PTSD after subsequent random traumas (odds ratio (OR)=1.3–2.5). We also assessed 14 lifetime DSM-IV mood, anxiety, disruptive behavior and substance disorders before random traumas. We show in the current report that only prior anxiety disorders significantly predicted PTSD in a multivariate model (OR=1.5–4.3) and that these disorders interacted significantly with three of the earlier traumas (witnessing atrocities, physical violence victimization and rape). History of witnessing atrocities significantly predicted PTSD after subsequent random traumas only among respondents with prior PTSD (OR=5.6). Histories of physical violence victimization (OR=1.5) and rape after age 17 years (OR=17.6) significantly predicted only among respondents with no history of prior anxiety disorders. Although only preliminary due to reliance on retrospective reports, these results suggest that history of anxiety disorders and history of a limited number of earlier traumas might usefully be targeted in future prospective studies as distinct foci of research on individual differences in vulnerability to PTSD after subsequent traumas.",
author = "RC Kessler and S Aguilar-Gaxiola and J Alonso and Bromet, {E. J.} and O Gureje and EG Karam and K Koenen and S. Lee and H Liu and BE Pennell and MV Petukhova and N.A Sampson and V. Shahly and DJ Stein and Lukoye Atwoli and G Borges and B Bunting and {de Girolamo}, G. and SF Gluzman and Haro, {J. M.} and H Hinkov and N Kawakami and V Kovess-Masfety and F Navarro-Mateu and J Posada-Villa and KM Scott and AY Shalev and {Ten Have}, M. and Y Torres and M.C Viana and AM Zaslavsky",
year = "2018",
month = "9",
doi = "10.1038/mp.2017.194",
language = "English",
volume = "23",
pages = "1892--1899",
journal = "Molecular Psychiatry",
issn = "1476-5578",

}

Kessler, RC, Aguilar-Gaxiola, S, Alonso, J, Bromet, EJ, Gureje, O, Karam, EG, Koenen, K, Lee, S, Liu, H, Pennell, BE, Petukhova, MV, Sampson, NA, Shahly, V, Stein, DJ, Atwoli, L, Borges, G, Bunting, B, de Girolamo, G, Gluzman, SF, Haro, JM, Hinkov, H, Kawakami, N, Kovess-Masfety, V, Navarro-Mateu, F, Posada-Villa, J, Scott, KM, Shalev, AY, Ten Have, M, Torres, Y, Viana, MC & Zaslavsky, AM 2018, 'The associations of earlier trauma exposures and history of mental disorders with PTSD after subsequent traumas', Molecular Psychiatry, vol. 23, pp. 1892-1899. https://doi.org/10.1038/mp.2017.194

The associations of earlier trauma exposures and history of mental disorders with PTSD after subsequent traumas. / Kessler, RC; Aguilar-Gaxiola, S; Alonso, J; Bromet, E. J.; Gureje, O; Karam, EG; Koenen, K; Lee, S.; Liu, H; Pennell, BE; Petukhova, MV; Sampson, N.A; Shahly, V.; Stein, DJ; Atwoli, Lukoye; Borges, G; Bunting, B; de Girolamo, G.; Gluzman, SF; Haro, J. M.; Hinkov, H; Kawakami, N; Kovess-Masfety, V; Navarro-Mateu, F; Posada-Villa, J; Scott, KM; Shalev, AY; Ten Have, M.; Torres, Y; Viana, M.C; Zaslavsky, AM.

In: Molecular Psychiatry, Vol. 23, 09.2018, p. 1892-1899.

Research output: Contribution to journalArticle

TY - JOUR

T1 - The associations of earlier trauma exposures and history of mental disorders with PTSD after subsequent traumas

AU - Kessler, RC

AU - Aguilar-Gaxiola, S

AU - Alonso, J

AU - Bromet, E. J.

AU - Gureje, O

AU - Karam, EG

AU - Koenen, K

AU - Lee, S.

AU - Liu, H

AU - Pennell, BE

AU - Petukhova, MV

AU - Sampson, N.A

AU - Shahly, V.

AU - Stein, DJ

AU - Atwoli, Lukoye

AU - Borges, G

AU - Bunting, B

AU - de Girolamo, G.

AU - Gluzman, SF

AU - Haro, J. M.

AU - Hinkov, H

AU - Kawakami, N

AU - Kovess-Masfety, V

AU - Navarro-Mateu, F

AU - Posada-Villa, J

AU - Scott, KM

AU - Shalev, AY

AU - Ten Have, M.

AU - Torres, Y

AU - Viana, M.C

AU - Zaslavsky, AM

PY - 2018/9

Y1 - 2018/9

N2 - Although earlier trauma exposure is known to predict posttraumatic stress disorder (PTSD) after subsequent traumas, it is unclear whether this association is limited to cases where the earlier trauma led to PTSD. Resolution of this uncertainty has important implications for research on pretrauma vulnerability to PTSD. We examined this issue in the World Health Organization (WHO) World Mental Health (WMH) Surveys with 34 676 respondents who reported lifetime trauma exposure. One lifetime trauma was selected randomly for each respondent. DSM-IV (Diagnostic and Statistical Manual of Mental Disorders, 4th Edition) PTSD due to that trauma was assessed. We reported in a previous paper that four earlier traumas involving interpersonal violence significantly predicted PTSD after subsequent random traumas (odds ratio (OR)=1.3–2.5). We also assessed 14 lifetime DSM-IV mood, anxiety, disruptive behavior and substance disorders before random traumas. We show in the current report that only prior anxiety disorders significantly predicted PTSD in a multivariate model (OR=1.5–4.3) and that these disorders interacted significantly with three of the earlier traumas (witnessing atrocities, physical violence victimization and rape). History of witnessing atrocities significantly predicted PTSD after subsequent random traumas only among respondents with prior PTSD (OR=5.6). Histories of physical violence victimization (OR=1.5) and rape after age 17 years (OR=17.6) significantly predicted only among respondents with no history of prior anxiety disorders. Although only preliminary due to reliance on retrospective reports, these results suggest that history of anxiety disorders and history of a limited number of earlier traumas might usefully be targeted in future prospective studies as distinct foci of research on individual differences in vulnerability to PTSD after subsequent traumas.

AB - Although earlier trauma exposure is known to predict posttraumatic stress disorder (PTSD) after subsequent traumas, it is unclear whether this association is limited to cases where the earlier trauma led to PTSD. Resolution of this uncertainty has important implications for research on pretrauma vulnerability to PTSD. We examined this issue in the World Health Organization (WHO) World Mental Health (WMH) Surveys with 34 676 respondents who reported lifetime trauma exposure. One lifetime trauma was selected randomly for each respondent. DSM-IV (Diagnostic and Statistical Manual of Mental Disorders, 4th Edition) PTSD due to that trauma was assessed. We reported in a previous paper that four earlier traumas involving interpersonal violence significantly predicted PTSD after subsequent random traumas (odds ratio (OR)=1.3–2.5). We also assessed 14 lifetime DSM-IV mood, anxiety, disruptive behavior and substance disorders before random traumas. We show in the current report that only prior anxiety disorders significantly predicted PTSD in a multivariate model (OR=1.5–4.3) and that these disorders interacted significantly with three of the earlier traumas (witnessing atrocities, physical violence victimization and rape). History of witnessing atrocities significantly predicted PTSD after subsequent random traumas only among respondents with prior PTSD (OR=5.6). Histories of physical violence victimization (OR=1.5) and rape after age 17 years (OR=17.6) significantly predicted only among respondents with no history of prior anxiety disorders. Although only preliminary due to reliance on retrospective reports, these results suggest that history of anxiety disorders and history of a limited number of earlier traumas might usefully be targeted in future prospective studies as distinct foci of research on individual differences in vulnerability to PTSD after subsequent traumas.

UR - https://pure.ulster.ac.uk/en/publications/the-associations-of-earlier-trauma-exposures-and-history-of-menta

U2 - 10.1038/mp.2017.194

DO - 10.1038/mp.2017.194

M3 - Article

VL - 23

SP - 1892

EP - 1899

JO - Molecular Psychiatry

T2 - Molecular Psychiatry

JF - Molecular Psychiatry

SN - 1476-5578

ER -