The Association Between Subjective Wellness Symptoms and Blood Biomarker Data in English Premier League Footballers

Marc Cleary, Fearghal McHugh, Kyle Paradis

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The present study investigates the association between subjective wellness symptoms, and categorical point-of-care (POC) blood biomarkers of the free oxygen radical test (FORT), and systemic inflammation through high sensitivity C-reactive protein (Hs-CRP), in English Premier League footballers. Data from 38 male professional elite athletes (Mean Age = 25.8, SD = 4.4) from the English Premier League were included in the study, with a total of 674 individual testing records collected over an entire Premier League season. A player wellness questionnaire, along with fasted and rested point-of-care blood biomarker testing were collected weekly across the season. The wellness questionnaire collected subjective symptoms of illness and fatigue, while FORT and Hs-CRP were assessed through point-of-care analysis to highlight periods of excessive hydroperoxide production and systemic inflammation. Using a chi square goodness of fit model, results showed that there was a significant association between the frequency of symptoms logged and categorical POC blood biomarker data of FORT and HsCRP (P < 0.01). Of the records demonstrating normal levels of Hs-CRP and FORT concentrations, 27% logged symptoms with an average of 1.5 symptoms reported per answered record. Comparatively, excessive biomarker values demonstrated 55% of records having symptoms logged, averaging 2.4 symptoms reported per record.

Original languageEnglish
Pages (from-to)340-347
Number of pages8
JournalJournal of Science in Sport and Exercise
Issue number4
Early online date29 Nov 2022
Publication statusPublished online - 29 Nov 2022

Bibliographical note

Publisher Copyright:
© 2022, The Author(s).


  • athlete wellness
  • blood biomarkers
  • premier league football
  • elite athletes
  • high performance sport


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