The Association between Early-life Relative Telomere Length and Childhood Neurodevelopment

Marina Oktapodas Feiler, Deven Patel, Huiqi Li, Philip J Meacham, Gene E Watson, Conrad F Shamlaye, Alison J. Yeates, Karin Broberg, Edwin van Wijngaarden

Research output: Contribution to journalArticle

Abstract

Purpose: To examine the association between telomere length and neurodevelopment in children. Methods: We examined the relationship between relative telomere length (rTL) and neurodevelopmental outcomes at 9 and 30 months, and 5 years of age in children enrolled in the Seychelles Child Development Study Nutrition Cohort 1 (NC1). Relative telomere length was measured in cord blood and in child blood at age five. Multivariable linear regression examined associations between neurodevelopmental outcomes and rTL adjusting for relevant covariates.Results: Mean rTL was 1.18 at birth and 0.71 at age five. Increased cord blood rTL was associated with better scores on two neurodevelopmental tests, the psychomotor developmental index (β =4.01; 95% confidence interval (CI)=0.17, 7.85) at age 30 months, and the Woodcock Johnson test of achievement letter-word score (β=2.88; CI=1.21-4.56) at age five. The Woodcock Johnson test of achievement letter-word score remained statistically significant after two outliers were excluded (β=2.83; CI=0.69, 4.97); the psychomotor developmental index did not (β =3.62; CI=-1.28, 8.52). None of the neurodevelopmental outcomes at age five were associated with five-year rTL. Conclusion: Although increased cord blood rTL was associated with better test scores for a few neurodevelopmental outcomes, this study found little consistent evidence of an association between rTL and neurodevelopment. Future studies with a larger sample size, longer follow-up, and other relevant biological markers (e.g. oxidative stress) are needed to clarify the role of rTL in neurodevelopment and its relevance as a potential surrogate measure for oxidative stress in the field of developmental neurotoxicity.
LanguageEnglish
Pages22-27
Number of pages5
JournalNeurotoxicology
Volume65
Early online date31 Jan 2018
DOIs
Publication statusE-pub ahead of print - 31 Jan 2018

Fingerprint

Telomere
Fetal Blood
Confidence Intervals
Oxidative Stress
Seychelles
Child Development
Sample Size
Linear Models
Cohort Studies
Biomarkers
Outcome Assessment (Health Care)
Parturition

Keywords

  • children
  • epidemiology
  • cognition
  • language

Cite this

Oktapodas Feiler, M., Patel, D., Li, H., Meacham, P. J., Watson, G. E., Shamlaye, C. F., ... van Wijngaarden, E. (2018). The Association between Early-life Relative Telomere Length and Childhood Neurodevelopment. Neurotoxicology, 65, 22-27. https://doi.org/10.1016/j.neuro.2018.01.005
Oktapodas Feiler, Marina ; Patel, Deven ; Li, Huiqi ; Meacham, Philip J ; Watson, Gene E ; Shamlaye, Conrad F ; Yeates, Alison J. ; Broberg, Karin ; van Wijngaarden, Edwin. / The Association between Early-life Relative Telomere Length and Childhood Neurodevelopment. In: Neurotoxicology. 2018 ; Vol. 65. pp. 22-27.
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abstract = "Purpose: To examine the association between telomere length and neurodevelopment in children. Methods: We examined the relationship between relative telomere length (rTL) and neurodevelopmental outcomes at 9 and 30 months, and 5 years of age in children enrolled in the Seychelles Child Development Study Nutrition Cohort 1 (NC1). Relative telomere length was measured in cord blood and in child blood at age five. Multivariable linear regression examined associations between neurodevelopmental outcomes and rTL adjusting for relevant covariates.Results: Mean rTL was 1.18 at birth and 0.71 at age five. Increased cord blood rTL was associated with better scores on two neurodevelopmental tests, the psychomotor developmental index (β =4.01; 95{\%} confidence interval (CI)=0.17, 7.85) at age 30 months, and the Woodcock Johnson test of achievement letter-word score (β=2.88; CI=1.21-4.56) at age five. The Woodcock Johnson test of achievement letter-word score remained statistically significant after two outliers were excluded (β=2.83; CI=0.69, 4.97); the psychomotor developmental index did not (β =3.62; CI=-1.28, 8.52). None of the neurodevelopmental outcomes at age five were associated with five-year rTL. Conclusion: Although increased cord blood rTL was associated with better test scores for a few neurodevelopmental outcomes, this study found little consistent evidence of an association between rTL and neurodevelopment. Future studies with a larger sample size, longer follow-up, and other relevant biological markers (e.g. oxidative stress) are needed to clarify the role of rTL in neurodevelopment and its relevance as a potential surrogate measure for oxidative stress in the field of developmental neurotoxicity.",
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Oktapodas Feiler, M, Patel, D, Li, H, Meacham, PJ, Watson, GE, Shamlaye, CF, Yeates, AJ, Broberg, K & van Wijngaarden, E 2018, 'The Association between Early-life Relative Telomere Length and Childhood Neurodevelopment', Neurotoxicology, vol. 65, pp. 22-27. https://doi.org/10.1016/j.neuro.2018.01.005

The Association between Early-life Relative Telomere Length and Childhood Neurodevelopment. / Oktapodas Feiler, Marina; Patel, Deven; Li, Huiqi; Meacham, Philip J; Watson, Gene E; Shamlaye, Conrad F; Yeates, Alison J.; Broberg, Karin; van Wijngaarden, Edwin.

In: Neurotoxicology, Vol. 65, 31.01.2018, p. 22-27.

Research output: Contribution to journalArticle

TY - JOUR

T1 - The Association between Early-life Relative Telomere Length and Childhood Neurodevelopment

AU - Oktapodas Feiler, Marina

AU - Patel, Deven

AU - Li, Huiqi

AU - Meacham, Philip J

AU - Watson, Gene E

AU - Shamlaye, Conrad F

AU - Yeates, Alison J.

AU - Broberg, Karin

AU - van Wijngaarden, Edwin

N1 - UIR non-compliant but the manuscript was uploaded and an appropriate embargo set before the embargo lifting

PY - 2018/1/31

Y1 - 2018/1/31

N2 - Purpose: To examine the association between telomere length and neurodevelopment in children. Methods: We examined the relationship between relative telomere length (rTL) and neurodevelopmental outcomes at 9 and 30 months, and 5 years of age in children enrolled in the Seychelles Child Development Study Nutrition Cohort 1 (NC1). Relative telomere length was measured in cord blood and in child blood at age five. Multivariable linear regression examined associations between neurodevelopmental outcomes and rTL adjusting for relevant covariates.Results: Mean rTL was 1.18 at birth and 0.71 at age five. Increased cord blood rTL was associated with better scores on two neurodevelopmental tests, the psychomotor developmental index (β =4.01; 95% confidence interval (CI)=0.17, 7.85) at age 30 months, and the Woodcock Johnson test of achievement letter-word score (β=2.88; CI=1.21-4.56) at age five. The Woodcock Johnson test of achievement letter-word score remained statistically significant after two outliers were excluded (β=2.83; CI=0.69, 4.97); the psychomotor developmental index did not (β =3.62; CI=-1.28, 8.52). None of the neurodevelopmental outcomes at age five were associated with five-year rTL. Conclusion: Although increased cord blood rTL was associated with better test scores for a few neurodevelopmental outcomes, this study found little consistent evidence of an association between rTL and neurodevelopment. Future studies with a larger sample size, longer follow-up, and other relevant biological markers (e.g. oxidative stress) are needed to clarify the role of rTL in neurodevelopment and its relevance as a potential surrogate measure for oxidative stress in the field of developmental neurotoxicity.

AB - Purpose: To examine the association between telomere length and neurodevelopment in children. Methods: We examined the relationship between relative telomere length (rTL) and neurodevelopmental outcomes at 9 and 30 months, and 5 years of age in children enrolled in the Seychelles Child Development Study Nutrition Cohort 1 (NC1). Relative telomere length was measured in cord blood and in child blood at age five. Multivariable linear regression examined associations between neurodevelopmental outcomes and rTL adjusting for relevant covariates.Results: Mean rTL was 1.18 at birth and 0.71 at age five. Increased cord blood rTL was associated with better scores on two neurodevelopmental tests, the psychomotor developmental index (β =4.01; 95% confidence interval (CI)=0.17, 7.85) at age 30 months, and the Woodcock Johnson test of achievement letter-word score (β=2.88; CI=1.21-4.56) at age five. The Woodcock Johnson test of achievement letter-word score remained statistically significant after two outliers were excluded (β=2.83; CI=0.69, 4.97); the psychomotor developmental index did not (β =3.62; CI=-1.28, 8.52). None of the neurodevelopmental outcomes at age five were associated with five-year rTL. Conclusion: Although increased cord blood rTL was associated with better test scores for a few neurodevelopmental outcomes, this study found little consistent evidence of an association between rTL and neurodevelopment. Future studies with a larger sample size, longer follow-up, and other relevant biological markers (e.g. oxidative stress) are needed to clarify the role of rTL in neurodevelopment and its relevance as a potential surrogate measure for oxidative stress in the field of developmental neurotoxicity.

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KW - epidemiology

KW - cognition

KW - language

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T2 - Neurotoxicology

JF - Neurotoxicology

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Oktapodas Feiler M, Patel D, Li H, Meacham PJ, Watson GE, Shamlaye CF et al. The Association between Early-life Relative Telomere Length and Childhood Neurodevelopment. Neurotoxicology. 2018 Jan 31;65:22-27. https://doi.org/10.1016/j.neuro.2018.01.005