The assessment of platelet derived growth factor concentration in post myocardial infarction and stable angina patients

Julie Wallace; JC Freeburn; WS Gilmore; DG Sinnamon; BM Craig; RJ McNally; JJ Strain

The assessment of platelet derived growth factor concentration in post myocardial infarction and stable angina patients

Julie Wallace, JC Freeburn, WS Gilmore, DG Sinnamon, BM Craig, RJ McNally, JJ Strain

Faculty Of Life & Health Sciences

Research output: Contribution to journal › Article › peer-review

8 Citations (Scopus)

Abstract

Platelet derived growth factor (PDGF) has been implicated in the pathogenesis of atherosclerosis. PDGF is released by aggregating platelets and monocytes which gather around sites of arterial injury. In the study reported here the concentration of plasma PDGF was measured in post myocardial infarction (MI) patients (n = 28). angina patients (n = 25), and control subjects (n = 27), Venous blood samples were taken and the concentration of PDGF determined by an enzyme linked immunosorbent assay (ELISA). Plasma PDGF concentrations were significantly higher ill the post MI group compared to both the control and angina groups (P less than or equal to 0.05). The increase in PDGF concentration may be due to increased activation of platelets or monocytes since these two cells are major sources of plasma PDGF, High concentrations of PDGF in the circulation could further accelerate the progression of the disease.

Original language	English
Pages (from-to)	236-241
Journal	Annals of Clinical Biochemistry
Volume	35
Issue number	Part 2
Publication status	Published (in print/issue) - Mar 1998

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title = "The assessment of platelet derived growth factor concentration in post myocardial infarction and stable angina patients",

abstract = "Platelet derived growth factor (PDGF) has been implicated in the pathogenesis of atherosclerosis. PDGF is released by aggregating platelets and monocytes which gather around sites of arterial injury. In the study reported here the concentration of plasma PDGF was measured in post myocardial infarction (MI) patients (n = 28). angina patients (n = 25), and control subjects (n = 27), Venous blood samples were taken and the concentration of PDGF determined by an enzyme linked immunosorbent assay (ELISA). Plasma PDGF concentrations were significantly higher ill the post MI group compared to both the control and angina groups (P less than or equal to 0.05). The increase in PDGF concentration may be due to increased activation of platelets or monocytes since these two cells are major sources of plasma PDGF, High concentrations of PDGF in the circulation could further accelerate the progression of the disease.",

author = "Julie Wallace and JC Freeburn and WS Gilmore and DG Sinnamon and BM Craig and RJ McNally and JJ Strain",

year = "1998",

month = mar,

language = "English",

volume = "35",

pages = "236--241",

journal = "Annals of Clinical Biochemistry",

issn = "1758-1001",

publisher = "SAGE Publications",

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TY - JOUR

T1 - The assessment of platelet derived growth factor concentration in post myocardial infarction and stable angina patients

AU - Wallace, Julie

AU - Freeburn, JC

AU - Gilmore, WS

AU - Sinnamon, DG

AU - Craig, BM

AU - McNally, RJ

AU - Strain, JJ

PY - 1998/3

Y1 - 1998/3

N2 - Platelet derived growth factor (PDGF) has been implicated in the pathogenesis of atherosclerosis. PDGF is released by aggregating platelets and monocytes which gather around sites of arterial injury. In the study reported here the concentration of plasma PDGF was measured in post myocardial infarction (MI) patients (n = 28). angina patients (n = 25), and control subjects (n = 27), Venous blood samples were taken and the concentration of PDGF determined by an enzyme linked immunosorbent assay (ELISA). Plasma PDGF concentrations were significantly higher ill the post MI group compared to both the control and angina groups (P less than or equal to 0.05). The increase in PDGF concentration may be due to increased activation of platelets or monocytes since these two cells are major sources of plasma PDGF, High concentrations of PDGF in the circulation could further accelerate the progression of the disease.

AB - Platelet derived growth factor (PDGF) has been implicated in the pathogenesis of atherosclerosis. PDGF is released by aggregating platelets and monocytes which gather around sites of arterial injury. In the study reported here the concentration of plasma PDGF was measured in post myocardial infarction (MI) patients (n = 28). angina patients (n = 25), and control subjects (n = 27), Venous blood samples were taken and the concentration of PDGF determined by an enzyme linked immunosorbent assay (ELISA). Plasma PDGF concentrations were significantly higher ill the post MI group compared to both the control and angina groups (P less than or equal to 0.05). The increase in PDGF concentration may be due to increased activation of platelets or monocytes since these two cells are major sources of plasma PDGF, High concentrations of PDGF in the circulation could further accelerate the progression of the disease.

M3 - Article

SN - 1758-1001

VL - 35

SP - 236

EP - 241

JO - Annals of Clinical Biochemistry

JF - Annals of Clinical Biochemistry

IS - Part 2

ER -

The assessment of platelet derived growth factor concentration in post myocardial infarction and stable angina patients

Abstract

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