The assessment of platelet derived growth factor concentration in post myocardial infarction and stable angina patients

Julie Wallace, JC Freeburn, WS Gilmore, DG Sinnamon, BM Craig, RJ McNally, JJ Strain

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Abstract

Platelet derived growth factor (PDGF) has been implicated in the pathogenesis of atherosclerosis. PDGF is released by aggregating platelets and monocytes which gather around sites of arterial injury. In the study reported here the concentration of plasma PDGF was measured in post myocardial infarction (MI) patients (n = 28). angina patients (n = 25), and control subjects (n = 27), Venous blood samples were taken and the concentration of PDGF determined by an enzyme linked immunosorbent assay (ELISA). Plasma PDGF concentrations were significantly higher ill the post MI group compared to both the control and angina groups (P less than or equal to 0.05). The increase in PDGF concentration may be due to increased activation of platelets or monocytes since these two cells are major sources of plasma PDGF, High concentrations of PDGF in the circulation could further accelerate the progression of the disease.
Original languageEnglish
Pages (from-to)236-241
JournalAnnals of Clinical Biochemistry
Volume35
Issue numberPart 2
Publication statusPublished - Mar 1998

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    Wallace, J., Freeburn, JC., Gilmore, WS., Sinnamon, DG., Craig, BM., McNally, RJ., & Strain, JJ. (1998). The assessment of platelet derived growth factor concentration in post myocardial infarction and stable angina patients. Annals of Clinical Biochemistry, 35(Part 2), 236-241.