Systematic Review of Observational Studies with Dose-Response Meta-Analysis between Folate Intake and Status Biomarkers in Adults and the Elderly

R Novakovic; A Geelen; D Ristic-Medic; M Nikolic; O.W. Souverein; H McNulty; M Duffy; L. Hoey; C Dullemeijer; J.M.S. Renkema; M Gurinovic; M Glibetic; L.C.P.G.M. de Groot; P van't Veer

doi:10.1159/000490003

Systematic Review of Observational Studies with Dose-Response Meta-Analysis between Folate Intake and Status Biomarkers in Adults and the Elderly

R Novakovic, A Geelen, D Ristic-Medic, M Nikolic, O.W. Souverein, H McNulty, M Duffy, L. Hoey, C Dullemeijer, J.M.S. Renkema, M Gurinovic, M Glibetic, L.C.P.G.M. de Groot, P van't Veer

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Abstract

Background: Dietary reference values for folate intake vary widely across Europe. Methods: MEDLINE and Embase through November 2016 were searched for data on the association between folate intake and biomarkers (serum/plasma folate, red blood cell [RBC] folate, plasma homocysteine) from observational studies in healthy adults and elderly. The regression coefficient of biomarkers on intake (β) was extracted from each study, and the overall and stratified pooled β and SE (β) were obtained by random effects meta-analysis on a double log scale. These dose-response estimates may be used to derive folate intake reference values. Results: For every doubling in folate intake, the changes in serum/plasma folate, RBC folate and plasma homocysteine were +22, +21, and –16% respectively. The overall pooled regression coefficients were β = 0.29 (95% CI 0.21–0.37) for serum/plasma folate (26 estimates from 17 studies), β = 0.28 (95% CI 0.21–0.36) for RBC (13 estimates from 11 studies), and β = –0.21 (95% CI –0.31 to –0.11) for plasma homocysteine (10 estimates from 6 studies). Conclusion: These estimates along with those from randomized controlled trials can be used for underpinning dietary recommendations for folate in adults and elderly.

Original language	English
Pages (from-to)	30
Number of pages	43
Journal	Annals of Nutrition and Metabolism
Volume	73
Issue number	1
Early online date	7 Jun 2018
DOIs	https://doi.org/10.1159/000490003
Publication status	Published - 31 Jul 2018

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Leane Hoey

l.hoey@ulster.ac.uk

School of Biomedical Sciences - Lecturer in Human Nutrition
Faculty Of Life & Health Sciences - Lecturer

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Novakovic, R., Geelen, A., Ristic-Medic, D., Nikolic, M., Souverein, O. W., McNulty, H., Duffy, M., Hoey, L., Dullemeijer, C., Renkema, J. M. S., Gurinovic, M., Glibetic, M., de Groot, L. C. P. G. M., & van't Veer, P. (2018). Systematic Review of Observational Studies with Dose-Response Meta-Analysis between Folate Intake and Status Biomarkers in Adults and the Elderly. Annals of Nutrition and Metabolism, 73(1), 30. https://doi.org/10.1159/000490003

Novakovic, R ; Geelen, A ; Ristic-Medic, D ; Nikolic, M ; Souverein, O.W. ; McNulty, H ; Duffy, M ; Hoey, L. ; Dullemeijer, C ; Renkema, J.M.S. ; Gurinovic, M ; Glibetic, M ; de Groot, L.C.P.G.M. ; van't Veer, P. / Systematic Review of Observational Studies with Dose-Response Meta-Analysis between Folate Intake and Status Biomarkers in Adults and the Elderly. In: Annals of Nutrition and Metabolism. 2018 ; Vol. 73, No. 1. pp. 30.

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title = "Systematic Review of Observational Studies with Dose-Response Meta-Analysis between Folate Intake and Status Biomarkers in Adults and the Elderly",

abstract = "Background: Dietary reference values for folate intake vary widely across Europe. Methods: MEDLINE and Embase through November 2016 were searched for data on the association between folate intake and biomarkers (serum/plasma folate, red blood cell [RBC] folate, plasma homocysteine) from observational studies in healthy adults and elderly. The regression coefficient of biomarkers on intake (β) was extracted from each study, and the overall and stratified pooled β and SE (β) were obtained by random effects meta-analysis on a double log scale. These dose-response estimates may be used to derive folate intake reference values. Results: For every doubling in folate intake, the changes in serum/plasma folate, RBC folate and plasma homocysteine were +22, +21, and –16% respectively. The overall pooled regression coefficients were β = 0.29 (95% CI 0.21–0.37) for serum/plasma folate (26 estimates from 17 studies), β = 0.28 (95% CI 0.21–0.36) for RBC (13 estimates from 11 studies), and β = –0.21 (95% CI –0.31 to –0.11) for plasma homocysteine (10 estimates from 6 studies). Conclusion: These estimates along with those from randomized controlled trials can be used for underpinning dietary recommendations for folate in adults and elderly.",

author = "R Novakovic and A Geelen and D Ristic-Medic and M Nikolic and O.W. Souverein and H McNulty and M Duffy and L. Hoey and C Dullemeijer and J.M.S. Renkema and M Gurinovic and M Glibetic and {de Groot}, L.C.P.G.M. and {van't Veer}, P",

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Novakovic, R, Geelen, A, Ristic-Medic, D, Nikolic, M, Souverein, OW, McNulty, H, Duffy, M, Hoey, L, Dullemeijer, C, Renkema, JMS, Gurinovic, M, Glibetic, M, de Groot, LCPGM & van't Veer, P 2018, 'Systematic Review of Observational Studies with Dose-Response Meta-Analysis between Folate Intake and Status Biomarkers in Adults and the Elderly', Annals of Nutrition and Metabolism, vol. 73, no. 1, pp. 30. https://doi.org/10.1159/000490003

Systematic Review of Observational Studies with Dose-Response Meta-Analysis between Folate Intake and Status Biomarkers in Adults and the Elderly. / Novakovic, R; Geelen, A; Ristic-Medic, D; Nikolic, M; Souverein, O.W.; McNulty, H; Duffy, M; Hoey, L.; Dullemeijer, C; Renkema, J.M.S.; Gurinovic, M; Glibetic, M; de Groot, L.C.P.G.M.; van't Veer, P.

In: Annals of Nutrition and Metabolism, Vol. 73, No. 1, 31.07.2018, p. 30.

Research output: Contribution to journal › Article

TY - JOUR

T1 - Systematic Review of Observational Studies with Dose-Response Meta-Analysis between Folate Intake and Status Biomarkers in Adults and the Elderly

AU - Novakovic, R

AU - Geelen, A

AU - Ristic-Medic, D

AU - Nikolic, M

AU - Souverein, O.W.

AU - McNulty, H

AU - Duffy, M

AU - Hoey, L.

AU - Dullemeijer, C

AU - Renkema, J.M.S.

AU - Gurinovic, M

AU - Glibetic, M

AU - de Groot, L.C.P.G.M.

AU - van't Veer, P

PY - 2018/7/31

Y1 - 2018/7/31

N2 - Background: Dietary reference values for folate intake vary widely across Europe. Methods: MEDLINE and Embase through November 2016 were searched for data on the association between folate intake and biomarkers (serum/plasma folate, red blood cell [RBC] folate, plasma homocysteine) from observational studies in healthy adults and elderly. The regression coefficient of biomarkers on intake (β) was extracted from each study, and the overall and stratified pooled β and SE (β) were obtained by random effects meta-analysis on a double log scale. These dose-response estimates may be used to derive folate intake reference values. Results: For every doubling in folate intake, the changes in serum/plasma folate, RBC folate and plasma homocysteine were +22, +21, and –16% respectively. The overall pooled regression coefficients were β = 0.29 (95% CI 0.21–0.37) for serum/plasma folate (26 estimates from 17 studies), β = 0.28 (95% CI 0.21–0.36) for RBC (13 estimates from 11 studies), and β = –0.21 (95% CI –0.31 to –0.11) for plasma homocysteine (10 estimates from 6 studies). Conclusion: These estimates along with those from randomized controlled trials can be used for underpinning dietary recommendations for folate in adults and elderly.

AB - Background: Dietary reference values for folate intake vary widely across Europe. Methods: MEDLINE and Embase through November 2016 were searched for data on the association between folate intake and biomarkers (serum/plasma folate, red blood cell [RBC] folate, plasma homocysteine) from observational studies in healthy adults and elderly. The regression coefficient of biomarkers on intake (β) was extracted from each study, and the overall and stratified pooled β and SE (β) were obtained by random effects meta-analysis on a double log scale. These dose-response estimates may be used to derive folate intake reference values. Results: For every doubling in folate intake, the changes in serum/plasma folate, RBC folate and plasma homocysteine were +22, +21, and –16% respectively. The overall pooled regression coefficients were β = 0.29 (95% CI 0.21–0.37) for serum/plasma folate (26 estimates from 17 studies), β = 0.28 (95% CI 0.21–0.36) for RBC (13 estimates from 11 studies), and β = –0.21 (95% CI –0.31 to –0.11) for plasma homocysteine (10 estimates from 6 studies). Conclusion: These estimates along with those from randomized controlled trials can be used for underpinning dietary recommendations for folate in adults and elderly.

UR - https://pure.ulster.ac.uk/en/publications/systematic-review-of-observational-studies-with-dose-response-met

U2 - 10.1159/000490003

DO - 10.1159/000490003

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SP - 30

JO - Annals of Nutrition and Metabolism

JF - Annals of Nutrition and Metabolism

SN - 0250-6807

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