Systematic Review of Observational Studies with Dose-Response Meta-Analysis between Folate Intake and Status Biomarkers in Adults and the Elderly

R Novakovic, A Geelen, D Ristic-Medic, M Nikolic, O.W. Souverein, H McNulty, M Duffy, L. Hoey, C Dullemeijer, J.M.S. Renkema, M Gurinovic, M Glibetic, L.C.P.G.M. de Groot, P van't Veer

Research output: Contribution to journalArticle

Abstract

Background: Dietary reference values for folate intake vary widely across Europe. Methods: MEDLINE and Embase through November 2016 were searched for data on the association between folate intake and biomarkers (serum/plasma folate, red blood cell [RBC] folate, plasma homocysteine) from observational studies in healthy adults and elderly. The regression coefficient of biomarkers on intake (β) was extracted from each study, and the overall and stratified pooled β and SE (β) were obtained by random effects meta-analysis on a double log scale. These dose-response estimates may be used to derive folate intake reference values. Results: For every doubling in folate intake, the changes in serum/plasma folate, RBC folate and plasma homocysteine were +22, +21, and –16% respectively. The overall pooled regression coefficients were β = 0.29 (95% CI 0.21–0.37) for serum/plasma folate (26 estimates from 17 studies), β = 0.28 (95% CI 0.21–0.36) for RBC (13 estimates from 11 studies), and β = –0.21 (95% CI –0.31 to –0.11) for plasma homocysteine (10 estimates from 6 studies). Conclusion: These estimates along with those from randomized controlled trials can be used for underpinning dietary recommendations for folate in adults and elderly.
LanguageEnglish
Pages30
Number of pages43
JournalAnnals of Nutrition and Metabolism
Volume73
Issue number1
Early online date7 Jun 2018
DOIs
Publication statusPublished - 31 Jul 2018

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Folic Acid
Observational Studies
Meta-Analysis
Biomarkers
Homocysteine
Erythrocytes
Reference Values
Serum
MEDLINE
Randomized Controlled Trials

Cite this

Novakovic, R ; Geelen, A ; Ristic-Medic, D ; Nikolic, M ; Souverein, O.W. ; McNulty, H ; Duffy, M ; Hoey, L. ; Dullemeijer, C ; Renkema, J.M.S. ; Gurinovic, M ; Glibetic, M ; de Groot, L.C.P.G.M. ; van't Veer, P. / Systematic Review of Observational Studies with Dose-Response Meta-Analysis between Folate Intake and Status Biomarkers in Adults and the Elderly. In: Annals of Nutrition and Metabolism. 2018 ; Vol. 73, No. 1. pp. 30.
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abstract = "Background: Dietary reference values for folate intake vary widely across Europe. Methods: MEDLINE and Embase through November 2016 were searched for data on the association between folate intake and biomarkers (serum/plasma folate, red blood cell [RBC] folate, plasma homocysteine) from observational studies in healthy adults and elderly. The regression coefficient of biomarkers on intake (β) was extracted from each study, and the overall and stratified pooled β and SE (β) were obtained by random effects meta-analysis on a double log scale. These dose-response estimates may be used to derive folate intake reference values. Results: For every doubling in folate intake, the changes in serum/plasma folate, RBC folate and plasma homocysteine were +22, +21, and –16{\%} respectively. The overall pooled regression coefficients were β = 0.29 (95{\%} CI 0.21–0.37) for serum/plasma folate (26 estimates from 17 studies), β = 0.28 (95{\%} CI 0.21–0.36) for RBC (13 estimates from 11 studies), and β = –0.21 (95{\%} CI –0.31 to –0.11) for plasma homocysteine (10 estimates from 6 studies). Conclusion: These estimates along with those from randomized controlled trials can be used for underpinning dietary recommendations for folate in adults and elderly.",
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Novakovic, R, Geelen, A, Ristic-Medic, D, Nikolic, M, Souverein, OW, McNulty, H, Duffy, M, Hoey, L, Dullemeijer, C, Renkema, JMS, Gurinovic, M, Glibetic, M, de Groot, LCPGM & van't Veer, P 2018, 'Systematic Review of Observational Studies with Dose-Response Meta-Analysis between Folate Intake and Status Biomarkers in Adults and the Elderly', Annals of Nutrition and Metabolism, vol. 73, no. 1, pp. 30. https://doi.org/10.1159/000490003

Systematic Review of Observational Studies with Dose-Response Meta-Analysis between Folate Intake and Status Biomarkers in Adults and the Elderly. / Novakovic, R; Geelen, A; Ristic-Medic, D; Nikolic, M; Souverein, O.W.; McNulty, H; Duffy, M; Hoey, L.; Dullemeijer, C; Renkema, J.M.S.; Gurinovic, M; Glibetic, M; de Groot, L.C.P.G.M.; van't Veer, P.

In: Annals of Nutrition and Metabolism, Vol. 73, No. 1, 31.07.2018, p. 30.

Research output: Contribution to journalArticle

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T1 - Systematic Review of Observational Studies with Dose-Response Meta-Analysis between Folate Intake and Status Biomarkers in Adults and the Elderly

AU - Novakovic, R

AU - Geelen, A

AU - Ristic-Medic, D

AU - Nikolic, M

AU - Souverein, O.W.

AU - McNulty, H

AU - Duffy, M

AU - Hoey, L.

AU - Dullemeijer, C

AU - Renkema, J.M.S.

AU - Gurinovic, M

AU - Glibetic, M

AU - de Groot, L.C.P.G.M.

AU - van't Veer, P

PY - 2018/7/31

Y1 - 2018/7/31

N2 - Background: Dietary reference values for folate intake vary widely across Europe. Methods: MEDLINE and Embase through November 2016 were searched for data on the association between folate intake and biomarkers (serum/plasma folate, red blood cell [RBC] folate, plasma homocysteine) from observational studies in healthy adults and elderly. The regression coefficient of biomarkers on intake (β) was extracted from each study, and the overall and stratified pooled β and SE (β) were obtained by random effects meta-analysis on a double log scale. These dose-response estimates may be used to derive folate intake reference values. Results: For every doubling in folate intake, the changes in serum/plasma folate, RBC folate and plasma homocysteine were +22, +21, and –16% respectively. The overall pooled regression coefficients were β = 0.29 (95% CI 0.21–0.37) for serum/plasma folate (26 estimates from 17 studies), β = 0.28 (95% CI 0.21–0.36) for RBC (13 estimates from 11 studies), and β = –0.21 (95% CI –0.31 to –0.11) for plasma homocysteine (10 estimates from 6 studies). Conclusion: These estimates along with those from randomized controlled trials can be used for underpinning dietary recommendations for folate in adults and elderly.

AB - Background: Dietary reference values for folate intake vary widely across Europe. Methods: MEDLINE and Embase through November 2016 were searched for data on the association between folate intake and biomarkers (serum/plasma folate, red blood cell [RBC] folate, plasma homocysteine) from observational studies in healthy adults and elderly. The regression coefficient of biomarkers on intake (β) was extracted from each study, and the overall and stratified pooled β and SE (β) were obtained by random effects meta-analysis on a double log scale. These dose-response estimates may be used to derive folate intake reference values. Results: For every doubling in folate intake, the changes in serum/plasma folate, RBC folate and plasma homocysteine were +22, +21, and –16% respectively. The overall pooled regression coefficients were β = 0.29 (95% CI 0.21–0.37) for serum/plasma folate (26 estimates from 17 studies), β = 0.28 (95% CI 0.21–0.36) for RBC (13 estimates from 11 studies), and β = –0.21 (95% CI –0.31 to –0.11) for plasma homocysteine (10 estimates from 6 studies). Conclusion: These estimates along with those from randomized controlled trials can be used for underpinning dietary recommendations for folate in adults and elderly.

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