Synthesis of piroxicam loaded novel electrospun biodegradable nanocomposite scaffolds for periodontal regeneration

Ariba Farooq, Muhammad Yar, Abdul Samad Khan, Lubna Shahzadi, Saadat Anwar Siddiqi, Nasir Mahmood, Abdul Rauf, Faisal Manzoor, Aqif Anwar Chaudhry, Ihtesham ur Rehman

Research output: Contribution to journalArticlepeer-review

53 Citations (Scopus)


Development of biodegradable composites having the ability to suppress or eliminate the pathogenic micro-biota or modulate the inflammatory response has attracted great interest in order to limit/repair periodontal tissue destruction. The present report includes the development of non-steroidal anti-inflammatory drug encapsulated novel biodegradable chitosan (CS)/poly(vinyl alcohol) (PVA)/hydroxyapatite (HA) electro-spun (e-spun) composite nanofibrous mats and films and study of the effect of heat treatment on fibers and films morphology. It also describes comparative in-vitro drug release profiles from heat treated and control (non-heat treated) nanofibrous mats and films containing varying concentrations of piroxicam (PX). Electrospinning was used to obtain drug loaded ultrafine fibrous mats. The physical/chemical interactions were evaluated by Fourier Transform Infrared (FT-IR) spectroscopy. The morphology, structure and pore size of the materials were investigated by scanning electron microscopy (SEM). The thermal behavior of the materials was investigated by thermal gravimetric analysis (TGA) and differential scanning calorimetry (DSC). Control (not heat treated) and heat treated e-spun fibers mats and films were tested for in vitro drug release studies at physiological pH 7.4 and initially, as per requirement burst release patterns were observed from both fibers and films and later sustained release profiles were noted. In vitro cytocompatibility was performed using VERO cell line of epithelial cells and all the synthesized materials were found to be non-cytotoxic. The current observations suggested that these materials are potential candidates for periodontal regeneration.
Original languageEnglish
Pages (from-to)104-113
Number of pages10
JournalMaterials Science and Engineering: C
Early online date14 Jun 2015
Publication statusPublished (in print/issue) - 1 Nov 2015


  • Periodontal regeneration
  • VERO cells
  • Chitosan
  • NSAIDs
  • Drug release


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