Synthesis of α- and β-calcitonin gene-related peptide by a human pheochromocytoma

J. Michael Conlon, Gerard P. McGregor, Staffan Gröndal, Lars Grimelius

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21 Citations (Scopus)

Abstract

One histologically verified human pheochromocytoma, out of a total of nine such tumors examined, contained calcitonin gene-related peptide (CGRP)-like immunoreactivity (151 pmol/g wet weight) that was localized to a scattered population of tumor cells. The immunoreactivity was resolved by high performance ion-exchange chromatography into two components with the retention times of human α-CGRP and β-CGRP in the approximate ration 1:2. No pheochromocytoma in this series contained calcitonin-like immunoreactivity. In contrast, two neuroendocrine tumors of the pancreas contained calcitonin-like immunoreactivity (190 pmol/g and 125 pmol/g) but no CGRP-like immunoreactivity was detected. These results indicate a degree of tissue selectivity in the processing of the primary transcripts of the calcitonin/CGRP genes in human tumors.

Original languageEnglish
Pages (from-to)327-331
Number of pages5
JournalPeptides
Volume10
Issue number2
DOIs
Publication statusPublished (in print/issue) - 1989

Keywords

  • Calcitonin
  • Calcitonin gene-related peptide (CGRP)
  • HPLC
  • Pheochromocytoma

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