Synthesis, Characterization, and Assessment of Anti-Cancer Potential of ZnO Nanoparticles in an In Vitro Model of Breast Cancer

Alaa Aljabali, Mohammad A. Obeid, hamid bakshi, Walhan Alshaer, Raed Ennab, bahaa altrad, Wesam Al Khateeb, Khalid Al-Batayneh, Abdulfattah Al-Kadash, Shrouq Alsotari, Hamdi Nsairat, Murtaza M. Tambuwala

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Abstract

Advanced innovations for combating variants of aggressive breast cancer and overcoming drug resistance are desired. In cancer treatment, ZnO nanoparticles (NPs) have the capacity to specifically and compellingly activate apoptosis of cancer cells. There is also a pressing need to develop innovative anti-cancer therapeutics, and recent research suggests that ZnO nanoparticles hold great potential. Here, the in vitro chemical effectiveness of ZnO NPs has been tested. Zinc oxide (ZnO) nanoparticles were synthesized using Citrullus colocynthis (L.) Schrad by green methods approach. The generated ZnO was observed to have a hexagonal wurtzite crystal arrangement. The generated nanomaterials were characterized by transmission electron microscopy (TEM), scanning electron microscopy (SEM), UV-visible spectroscopy. The crystallinity of ZnO was reported to be in the range 50–60 nm. The NPs morphology showed a strong absorbance at 374 nm with an estimated gap band of 3.20 eV to 3.32 eV. Microscopy analysis proved the morphology and distribution of the generated nanoparticles to be around 50 nm, with the elemental studies showing the elemental composition of ZnO and further confirming the purity of ZnO NPs. The cytotoxic effect of ZnO NPs was evaluated against wild-type and doxorubicin-resistant MCF-7 and MDA-MB-231 breast cancer cell lines. The results showed the ability of ZnO NPs to inhibit the prefoliation of MCF-7 and MDA-MB-231 prefoliation through the induction of apoptosis without significant differences in both wild-type and resistance to doxorubicin.
Original languageEnglish
Article number1827
Pages (from-to)1-13
Number of pages13
JournalMolecules
Volume27
Issue number6
Early online date11 Mar 2022
DOIs
Publication statusPublished - 11 Mar 2022

Bibliographical note

Funding Information:
Funding: This research was funded by The Deanship of Scientific Research and Graduate Studies at Yarmouk University, Irbid, Jordan, grant number 28/2021 and “The APC was funded by Authors”.

Publisher Copyright:
© 2022 by the authors. Licensee MDPI, Basel, Switzerland.

Keywords

  • Cancer
  • drug delivery
  • Pharmaceutical formulations
  • Nanoparticles
  • Zinc oxide nanoparticles
  • Triple negative
  • Green synthesis
  • Anti-cancer therapy
  • Nanomedicine

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