Synthesis and Evaluation of Herbal Chitosan from Ganoderma Lucidum Spore Powder for Biomedical Applications

Li Fang Zhu, Zhi Cheng Yao, Zeeshan Ahmad, Jing Song Li, Ming Wei Chang

Research output: Contribution to journalArticle

1 Citation (Scopus)

Abstract

Chitosan is an extremely valuable biopolymer and is usually obtained as a byproduct from the shells of crustaceans. In the current work, chitosan is obtained from an herbal source (Ganoderma lucidum spore powder (GLSP)) for the first time. To show this, both standard (thermochemical deacetylation, (TCD)) and emerging (ultrasound-assisted deacetylation (USAD)) methods of chitosan preparation were used. The obtained chitosan was characterized by elemental analysis, XRD (X-ray diffraction), FT-IR (Fourier transform infrared spectroscopy) and thermogravimetric measurements. The process resulted in chitosan possessing comparable values of DD, [η] and Mv¯ to the commercial product. Chitosan obtained via both processes (TCD and USAD) displayed excellent biocompatibility; although the USAD prepared biopolymer exhibited significantly improved fibroblast (L929 cell) viability and enhanced antibacterial zones for both Escherichia coli (E. coli) and Staphylococcus aureus (S. aureus). The findings of new herbal chitosan mark key developments of natural biomaterials; marking a potential shift from conventional sea-based organisms.

LanguageEnglish
Article number14608
JournalScientific Reports
Volume8
Issue number1
DOIs
Publication statusPublished - 2 Oct 2018

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Reishi
Chitosan
Spores
Powders
Biopolymers
Biocompatible Materials
Fourier Transform Infrared Spectroscopy
X-Ray Diffraction
Oceans and Seas
Staphylococcus aureus
Cell Survival
Fibroblasts
Escherichia coli

Cite this

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title = "Synthesis and Evaluation of Herbal Chitosan from Ganoderma Lucidum Spore Powder for Biomedical Applications",
abstract = "Chitosan is an extremely valuable biopolymer and is usually obtained as a byproduct from the shells of crustaceans. In the current work, chitosan is obtained from an herbal source (Ganoderma lucidum spore powder (GLSP)) for the first time. To show this, both standard (thermochemical deacetylation, (TCD)) and emerging (ultrasound-assisted deacetylation (USAD)) methods of chitosan preparation were used. The obtained chitosan was characterized by elemental analysis, XRD (X-ray diffraction), FT-IR (Fourier transform infrared spectroscopy) and thermogravimetric measurements. The process resulted in chitosan possessing comparable values of DD, [η] and Mv¯ to the commercial product. Chitosan obtained via both processes (TCD and USAD) displayed excellent biocompatibility; although the USAD prepared biopolymer exhibited significantly improved fibroblast (L929 cell) viability and enhanced antibacterial zones for both Escherichia coli (E. coli) and Staphylococcus aureus (S. aureus). The findings of new herbal chitosan mark key developments of natural biomaterials; marking a potential shift from conventional sea-based organisms.",
author = "Zhu, {Li Fang} and Yao, {Zhi Cheng} and Zeeshan Ahmad and Li, {Jing Song} and Chang, {Ming Wei}",
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Synthesis and Evaluation of Herbal Chitosan from Ganoderma Lucidum Spore Powder for Biomedical Applications. / Zhu, Li Fang; Yao, Zhi Cheng; Ahmad, Zeeshan; Li, Jing Song; Chang, Ming Wei.

In: Scientific Reports, Vol. 8, No. 1, 14608, 02.10.2018.

Research output: Contribution to journalArticle

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