Synthesis and Evaluation of a Series of Long-Acting Glucagon-Like Peptide-1 (GLP-1) Pentasaccharide Conjugates for the Treatment of Type 2 Diabetes.

Nigel Irwin, S Patterson, M de Kort, Charlotte Moffett, JA Wisse, WH Dokter, ES Bos, AM Miltenburg, Peter Flatt

Research output: Contribution to journalArticle

4 Citations (Scopus)

Abstract

The present study details the development of a family of novel D-Ala(8) glucagon-like peptide-1 (GLP-1) peptide conjugates by site specific conjugation to an antithrombin III (ATIII) binding carrier pentasaccharide through tetraethylene glycol linkers. All conjugates were found to possess potent insulin-releasing activity. Peptides with short linkers (
LanguageEnglish
Pages1424-1434.
JournalChemMedChem
Volume10
Issue number(8)
DOIs
Publication statusPublished - 1 Aug 2015

Fingerprint

Glucagon-Like Peptide 1
Medical problems
Peptides
Glycols
Antithrombin III
Insulin

Keywords

  • conjugates
  • dipeptidyl peptidase IV
  • glucagon-like peptide-1
  • glucose homeostasis
  • insulin
  • liraglutide

Cite this

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Synthesis and Evaluation of a Series of Long-Acting Glucagon-Like Peptide-1 (GLP-1) Pentasaccharide Conjugates for the Treatment of Type 2 Diabetes. / Irwin, Nigel; Patterson, S; de Kort, M; Moffett, Charlotte; Wisse, JA; Dokter, WH; Bos, ES; Miltenburg, AM; Flatt, Peter.

In: ChemMedChem, Vol. 10, No. (8), 01.08.2015, p. 1424-1434.

Research output: Contribution to journalArticle

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AU - Bos, ES

AU - Miltenburg, AM

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