Synovial membrane immunohistology in early untreated juvenile idiopathic arthritis: differences between clinical subgroups

Sorcha Finnegan, Susan Clarke, David Gibson, Catherine McAllister, Madeleine Rooney

    Research output: Contribution to journalArticle

    Abstract

    Objective Juvenile idiopathic arthritis (JIA) consists of a heterogeneous group of infl ammatory disorders, within which there are a number of clinical subgroups. Diagnosis and assignment to a particular subgroup can be problematical and more concise methods of subgroup classifi cation are required. This study of the synovial membrane characterises the immunohistochemical features in early untreated, newly diagnosed JIA and compares fi ndings with disease subgroup at 2 years.Methods 42 patients with newly diagnosed untreated JIA underwent synovial biopsy before the administration of steroids or disease-modifying antirheumatic drugs. Patients were classifi ed as either polyarticular, persistent oligoarticular or extended-to-be oligoarticular. The location and semiquantitative analysis of T-cell subsets, B cells, macrophages and blood vessels were determined using immunohistochemistry.Results Synovial hyperplasia varied signifi cantly between the three groups (p
    LanguageEnglish
    Pages1842-1850
    JournalAnnals of the Rheumatic Diseases
    Volume70
    Publication statusPublished - 16 Jun 2011

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    Antirheumatic Agents
    T-cells
    Juvenile Arthritis
    Synovial Membrane
    Biopsy
    Macrophages
    Blood vessels
    Cations
    Steroids
    Cells
    Membranes
    T-Lymphocyte Subsets
    Hyperplasia
    Blood Vessels
    B-Lymphocytes
    Immunohistochemistry

    Cite this

    Finnegan, Sorcha ; Clarke, Susan ; Gibson, David ; McAllister, Catherine ; Rooney, Madeleine. / Synovial membrane immunohistology in early untreated juvenile idiopathic arthritis: differences between clinical subgroups. In: Annals of the Rheumatic Diseases. 2011 ; Vol. 70. pp. 1842-1850.
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    Synovial membrane immunohistology in early untreated juvenile idiopathic arthritis: differences between clinical subgroups. / Finnegan, Sorcha; Clarke, Susan; Gibson, David; McAllister, Catherine; Rooney, Madeleine.

    In: Annals of the Rheumatic Diseases, Vol. 70, 16.06.2011, p. 1842-1850.

    Research output: Contribution to journalArticle

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