Synovial fluid proteome expression patterns segregate juvenile idiopathic arthritis patients

David Gibson; Sarah Blelock; Jim Curry; Sorcha Finnegan; Adrienne Healy; Catriona Scaife; Catherine McAllister; Stephen Pennington; Michael Dunn; Madeleine Rooney

doi:10.1093/rheumatology/kem512

Synovial fluid proteome expression patterns segregate juvenile idiopathic arthritis patients

David Gibson, Sarah Blelock, Jim Curry, Sorcha Finnegan, Adrienne Healy, Catriona Scaife, Catherine McAllister, Stephen Pennington, Michael Dunn, Madeleine Rooney

Research output: Chapter in Book/Report/Conference proceeding › Conference contribution › peer-review

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Abstract

Background: Synovial fluid (SF) is a potential source of novel biomarkers formany arthritic disorders involving joint inflammation, including Juvenile IdiopathicArthritis (JIA). We first compared the distinctive protein expression patterns of localjoint inflammation in SF with systemic profiles within matched plasma samples.Preliminary investigations were performed into whether local or systemic proteome‘fingerprints’ could distinguish between oligoarticular, extended oligoarticular andpolyarticular forms of this chronic juvenile disease.Methods: In this study we analysed matched SF and plasma samples obtainedfrom 10 newly diagnosed JIA patients (

Original language	English
Title of host publication	Rheumatology
Publisher	Oxford University Press
Pages	ii27
Number of pages	1
Volume	47
Edition	2
DOIs	https://doi.org/10.1093/rheumatology/kem512
Publication status	Published (in print/issue) - 2008
Event	British Society for Rheumatology - Liverpool Duration: 1 Jan 2008 → …

Conference

Conference	British Society for Rheumatology
Period	1/01/08 → …

Keywords

Juvenile arthritis
Synovial fluid
proteome
bioinformatics

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10.1093/rheumatology/kem512

BSR 2008 abstracts GibsonFinal published version, 44.2 KB

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title = "Synovial fluid proteome expression patterns segregate juvenile idiopathic arthritis patients",

abstract = "Background: Synovial fluid (SF) is a potential source of novel biomarkers formany arthritic disorders involving joint inflammation, including Juvenile IdiopathicArthritis (JIA). We first compared the distinctive protein expression patterns of localjoint inflammation in SF with systemic profiles within matched plasma samples.Preliminary investigations were performed into whether local or systemic proteome{\textquoteleft}fingerprints{\textquoteright} could distinguish between oligoarticular, extended oligoarticular andpolyarticular forms of this chronic juvenile disease.Methods: In this study we analysed matched SF and plasma samples obtainedfrom 10 newly diagnosed JIA patients (",

keywords = "Juvenile arthritis, Synovial fluid, proteome, bioinformatics",

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Gibson, D, Blelock, S, Curry, J, Finnegan, S, Healy, A, Scaife, C, McAllister, C, Pennington, S, Dunn, M & Rooney, M 2008, Synovial fluid proteome expression patterns segregate juvenile idiopathic arthritis patients. in Rheumatology. 2 edn, vol. 47, Oxford University Press, pp. ii27, British Society for Rheumatology, 1/01/08. https://doi.org/10.1093/rheumatology/kem512

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AU - Gibson, David

AU - Blelock, Sarah

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AU - Finnegan, Sorcha

AU - Healy, Adrienne

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AU - McAllister, Catherine

AU - Pennington, Stephen

AU - Dunn, Michael

AU - Rooney, Madeleine

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N2 - Background: Synovial fluid (SF) is a potential source of novel biomarkers formany arthritic disorders involving joint inflammation, including Juvenile IdiopathicArthritis (JIA). We first compared the distinctive protein expression patterns of localjoint inflammation in SF with systemic profiles within matched plasma samples.Preliminary investigations were performed into whether local or systemic proteome‘fingerprints’ could distinguish between oligoarticular, extended oligoarticular andpolyarticular forms of this chronic juvenile disease.Methods: In this study we analysed matched SF and plasma samples obtainedfrom 10 newly diagnosed JIA patients (

AB - Background: Synovial fluid (SF) is a potential source of novel biomarkers formany arthritic disorders involving joint inflammation, including Juvenile IdiopathicArthritis (JIA). We first compared the distinctive protein expression patterns of localjoint inflammation in SF with systemic profiles within matched plasma samples.Preliminary investigations were performed into whether local or systemic proteome‘fingerprints’ could distinguish between oligoarticular, extended oligoarticular andpolyarticular forms of this chronic juvenile disease.Methods: In this study we analysed matched SF and plasma samples obtainedfrom 10 newly diagnosed JIA patients (

KW - Juvenile arthritis

KW - Synovial fluid

KW - proteome

KW - bioinformatics

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DO - 10.1093/rheumatology/kem512

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Synovial fluid proteome expression patterns segregate juvenile idiopathic arthritis patients

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