Synovial fluid proteome expression patterns segregate juvenile idiopathic arthritis patients

David Gibson, Sarah Blelock, Jim Curry, Sorcha Finnegan, Adrienne Healy, Catriona Scaife, Catherine McAllister, Stephen Pennington, Michael Dunn, Madeleine Rooney

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    Background: Synovial fluid (SF) is a potential source of novel biomarkers formany arthritic disorders involving joint inflammation, including Juvenile IdiopathicArthritis (JIA). We first compared the distinctive protein expression patterns of localjoint inflammation in SF with systemic profiles within matched plasma samples.Preliminary investigations were performed into whether local or systemic proteome‘fingerprints’ could distinguish between oligoarticular, extended oligoarticular andpolyarticular forms of this chronic juvenile disease.Methods: In this study we analysed matched SF and plasma samples obtainedfrom 10 newly diagnosed JIA patients (
    Original languageEnglish
    Title of host publicationRheumatology
    PublisherOxford University Press
    Number of pages1
    Publication statusPublished (in print/issue) - 2008
    EventBritish Society for Rheumatology - Liverpool
    Duration: 1 Jan 2008 → …


    ConferenceBritish Society for Rheumatology
    Period1/01/08 → …


    • Juvenile arthritis
    • Synovial fluid
    • proteome
    • bioinformatics


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