Synovial fluid proteome expression patterns segregate juvenile idiopathic arthritis patients

David Gibson, Sarah Blelock, Jim Curry, Sorcha Finnegan, Adrienne Healy, Catriona Scaife, Catherine McAllister, Stephen Pennington, Michael Dunn, Madeleine Rooney

Research output: Chapter in Book/Report/Conference proceedingConference contributionpeer-review

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Abstract

Background: Synovial fluid (SF) is a potential source of novel biomarkers formany arthritic disorders involving joint inflammation, including Juvenile IdiopathicArthritis (JIA). We first compared the distinctive protein expression patterns of localjoint inflammation in SF with systemic profiles within matched plasma samples.Preliminary investigations were performed into whether local or systemic proteome‘fingerprints’ could distinguish between oligoarticular, extended oligoarticular andpolyarticular forms of this chronic juvenile disease.Methods: In this study we analysed matched SF and plasma samples obtainedfrom 10 newly diagnosed JIA patients (
Original languageEnglish
Title of host publicationRheumatology
PublisherOxford University Press
Pagesii27
Number of pages1
Volume47
Edition2
DOIs
Publication statusPublished (in print/issue) - 2008
EventBritish Society for Rheumatology - Liverpool
Duration: 1 Jan 2008 → …

Conference

ConferenceBritish Society for Rheumatology
Period1/01/08 → …

Keywords

  • Juvenile arthritis
  • Synovial fluid
  • proteome
  • bioinformatics

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