Sustained glucagon receptor antagonism in insulin deficient high fat fed mice

Ryan Lafferty, Laura McShane, Zara Franklin, PR Flatt, Finbarr O'Harte, Nigel Irwin

Research output: Contribution to journalArticlepeer-review

Abstract

Discerning modification to the amino acid sequence of native glucagon can generate specific glucagon receptor (GCGR) antagonists, that include desHis1Pro4Glu9-glucagon and the acylated form desHis1Pro4Glu9(Lys12PAL)-glucagon. In the current study, we have evaluated the metabolic benefits of once daily injection of these peptide-based GCGR antagonists for 18 days in insulin-resistant high fat fed (HFF) mice with streptozotocin (STZ)-induced insulin deficiency, namely HFF-STZ mice. Administration of desHis1Pro4Glu9-glucagon moderately (P
Original languageEnglish
Pages (from-to)10.1530/JOE-22-0106
JournalJournal of Endrocrinology
DOIs
Publication statusAccepted/In press - 24 Aug 2022

Keywords

  • glucagon
  • glucose homeostasis
  • insulin sensitivity
  • high fat fed mice
  • streptozotocin

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