Survival and health in liveborn infants with transposition of great arteries – A population based study

Ester Garne, Maria Loane, Vera Nelen, Marian Bakker, Blanca Gener, Lenore Abramsky, Marie-Claude Addor, Annette Queisser-Luft

Research output: Contribution to journalArticle

7 Citations (Scopus)

Abstract

Objective. To describe treatment, survival, and morbidity for liveborn infants with isolated transposition of great arteries (TGA).Design. Population-based data from 7 European registries of congenital malformations (EUROCAT).Results. Ninety-seven infants were diagnosed with isolated TGA and livebirth prevalence was 2.0 per 10 000 livebirths. The majority of infants were treated with prostaglandins (83%) and 57% had a catheter atrial septostomia performed. Arterial switch surgery was performed in 78 infants, other or unknown type of surgery was performed in 3 cases, and for 6 infants there was no information on surgery. At 1 year of age 69 infants were alive (71%) and 24 (25%) were dead (4 unknown). There were 10 deaths before surgery and 58% of all deaths took place during the first week. There was no statistically significant regional difference in mortality. Eight infants diagnosed prenatally all survived to 1 year and only 71% of infants diagnosed after birth survived (P = 0.08). Data on morbidity at 1 year of age was available for 57 infants. Fifty-one infants were reported with normal health and development.Conclusions. In this population-based study survival for liveborn infants with TGA is lower than in studies published from tertiary centers. Outcome for survivors at 1 year of age seems favorable.
LanguageEnglish
Pages165-169
JournalCongenital Heart Disease
Volume2
Issue number3
DOIs
Publication statusPublished - 2007

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Transposition of Great Vessels
Survival
Health
Population
Morbidity
Prostaglandins
Survivors
Registries
Catheters
Parturition

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Garne, Ester ; Loane, Maria ; Nelen, Vera ; Bakker, Marian ; Gener, Blanca ; Abramsky, Lenore ; Addor, Marie-Claude ; Queisser-Luft, Annette. / Survival and health in liveborn infants with transposition of great arteries – A population based study. In: Congenital Heart Disease. 2007 ; Vol. 2, No. 3. pp. 165-169.
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abstract = "Objective. To describe treatment, survival, and morbidity for liveborn infants with isolated transposition of great arteries (TGA).Design. Population-based data from 7 European registries of congenital malformations (EUROCAT).Results. Ninety-seven infants were diagnosed with isolated TGA and livebirth prevalence was 2.0 per 10 000 livebirths. The majority of infants were treated with prostaglandins (83{\%}) and 57{\%} had a catheter atrial septostomia performed. Arterial switch surgery was performed in 78 infants, other or unknown type of surgery was performed in 3 cases, and for 6 infants there was no information on surgery. At 1 year of age 69 infants were alive (71{\%}) and 24 (25{\%}) were dead (4 unknown). There were 10 deaths before surgery and 58{\%} of all deaths took place during the first week. There was no statistically significant regional difference in mortality. Eight infants diagnosed prenatally all survived to 1 year and only 71{\%} of infants diagnosed after birth survived (P = 0.08). Data on morbidity at 1 year of age was available for 57 infants. Fifty-one infants were reported with normal health and development.Conclusions. In this population-based study survival for liveborn infants with TGA is lower than in studies published from tertiary centers. Outcome for survivors at 1 year of age seems favorable.",
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Survival and health in liveborn infants with transposition of great arteries – A population based study. / Garne, Ester; Loane, Maria; Nelen, Vera; Bakker, Marian; Gener, Blanca; Abramsky, Lenore; Addor, Marie-Claude; Queisser-Luft, Annette.

In: Congenital Heart Disease, Vol. 2, No. 3, 2007, p. 165-169.

Research output: Contribution to journalArticle

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AU - Addor, Marie-Claude

AU - Queisser-Luft, Annette

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N2 - Objective. To describe treatment, survival, and morbidity for liveborn infants with isolated transposition of great arteries (TGA).Design. Population-based data from 7 European registries of congenital malformations (EUROCAT).Results. Ninety-seven infants were diagnosed with isolated TGA and livebirth prevalence was 2.0 per 10 000 livebirths. The majority of infants were treated with prostaglandins (83%) and 57% had a catheter atrial septostomia performed. Arterial switch surgery was performed in 78 infants, other or unknown type of surgery was performed in 3 cases, and for 6 infants there was no information on surgery. At 1 year of age 69 infants were alive (71%) and 24 (25%) were dead (4 unknown). There were 10 deaths before surgery and 58% of all deaths took place during the first week. There was no statistically significant regional difference in mortality. Eight infants diagnosed prenatally all survived to 1 year and only 71% of infants diagnosed after birth survived (P = 0.08). Data on morbidity at 1 year of age was available for 57 infants. Fifty-one infants were reported with normal health and development.Conclusions. In this population-based study survival for liveborn infants with TGA is lower than in studies published from tertiary centers. Outcome for survivors at 1 year of age seems favorable.

AB - Objective. To describe treatment, survival, and morbidity for liveborn infants with isolated transposition of great arteries (TGA).Design. Population-based data from 7 European registries of congenital malformations (EUROCAT).Results. Ninety-seven infants were diagnosed with isolated TGA and livebirth prevalence was 2.0 per 10 000 livebirths. The majority of infants were treated with prostaglandins (83%) and 57% had a catheter atrial septostomia performed. Arterial switch surgery was performed in 78 infants, other or unknown type of surgery was performed in 3 cases, and for 6 infants there was no information on surgery. At 1 year of age 69 infants were alive (71%) and 24 (25%) were dead (4 unknown). There were 10 deaths before surgery and 58% of all deaths took place during the first week. There was no statistically significant regional difference in mortality. Eight infants diagnosed prenatally all survived to 1 year and only 71% of infants diagnosed after birth survived (P = 0.08). Data on morbidity at 1 year of age was available for 57 infants. Fifty-one infants were reported with normal health and development.Conclusions. In this population-based study survival for liveborn infants with TGA is lower than in studies published from tertiary centers. Outcome for survivors at 1 year of age seems favorable.

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