Survey of prenatal screening policies in Europe for structural malformations and chromosome anomalies, and their impact on detection and termination rates for Neural Tube Defects and Down’s syndrome

Patricia A Boyd, Catherine DeVigan, Babak Khoshnood, Maria Loane, Ester Garne, Helen Dolk, Working Group EUROCAT

Research output: Contribution to journalArticle

189 Citations (Scopus)

Abstract

Objective To 'map' the current (2004) state of prenatal screening in Europe.Design (i) Survey of country policies and (ii) analysis of data from EUROCAT (European Surveillance of Congenital Anomalies) population-based congenital anomaly registers.Setting Europe.Population Survey of prenatal screening policies in 18 countries and 1.13 million births in 12 countries in 2002–04.Methods (i) Questionnaire on national screening policies and termination of pregnancy for fetal anomaly (TOPFA) laws in 2004. (ii) Analysis of data on prenatal detection and termination for Down's syndrome and neural tube defects (NTDs) using the EUROCAT database.Main outcome measures Existence of national prenatal screening policies, legal gestation limit for TOPFA, prenatal detection and termination rates for Down's syndrome and NTD.Results Ten of the 18 countries had a national country-wide policy for Down's syndrome screening and 14/18 for structural anomaly scanning. Sixty-eight percent of Down's syndrome cases (range 0–95%) were detected prenatally, of which 88% resulted in termination of pregnancy. Eighty-eight percent (range 25–94%) of cases of NTD were prenatally detected, of which 88% resulted in termination. Countries with a first-trimester screening policy had the highest proportion of prenatally diagnosed Down's syndrome cases. Countries with no official national Down's syndrome screening or structural anomaly scan policy had the lowest proportion of prenatally diagnosed Down's syndrome and NTD cases. Six of the 18 countries had a legal gestational age limit for TOPFA, and in two countries, termination of pregnancy was illegal at any gestation.Conclusions There are large differences in screening policies between countries in Europe. These, as well as organisational and cultural factors, are associated with wide country variation in prenatal detection rates for Down's syndrome and NTD.
LanguageEnglish
Pages689-696
JournalBritish Journal Obstetrics & Gynaecology
Volume115
Issue number6
DOIs
Publication statusPublished - May 2008

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Neural Tube Defects
Down Syndrome
Prenatal Diagnosis
Chromosomes
Pregnancy
Surveys and Questionnaires
Policy Making
First Pregnancy Trimester
Population
Gestational Age
Outcome Assessment (Health Care)
Parturition
Databases

Cite this

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title = "Survey of prenatal screening policies in Europe for structural malformations and chromosome anomalies, and their impact on detection and termination rates for Neural Tube Defects and Down’s syndrome",
abstract = "Objective To 'map' the current (2004) state of prenatal screening in Europe.Design (i) Survey of country policies and (ii) analysis of data from EUROCAT (European Surveillance of Congenital Anomalies) population-based congenital anomaly registers.Setting Europe.Population Survey of prenatal screening policies in 18 countries and 1.13 million births in 12 countries in 2002–04.Methods (i) Questionnaire on national screening policies and termination of pregnancy for fetal anomaly (TOPFA) laws in 2004. (ii) Analysis of data on prenatal detection and termination for Down's syndrome and neural tube defects (NTDs) using the EUROCAT database.Main outcome measures Existence of national prenatal screening policies, legal gestation limit for TOPFA, prenatal detection and termination rates for Down's syndrome and NTD.Results Ten of the 18 countries had a national country-wide policy for Down's syndrome screening and 14/18 for structural anomaly scanning. Sixty-eight percent of Down's syndrome cases (range 0–95{\%}) were detected prenatally, of which 88{\%} resulted in termination of pregnancy. Eighty-eight percent (range 25–94{\%}) of cases of NTD were prenatally detected, of which 88{\%} resulted in termination. Countries with a first-trimester screening policy had the highest proportion of prenatally diagnosed Down's syndrome cases. Countries with no official national Down's syndrome screening or structural anomaly scan policy had the lowest proportion of prenatally diagnosed Down's syndrome and NTD cases. Six of the 18 countries had a legal gestational age limit for TOPFA, and in two countries, termination of pregnancy was illegal at any gestation.Conclusions There are large differences in screening policies between countries in Europe. These, as well as organisational and cultural factors, are associated with wide country variation in prenatal detection rates for Down's syndrome and NTD.",
author = "Boyd, {Patricia A} and Catherine DeVigan and Babak Khoshnood and Maria Loane and Ester Garne and Helen Dolk and EUROCAT, {Working Group}",
year = "2008",
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language = "English",
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Survey of prenatal screening policies in Europe for structural malformations and chromosome anomalies, and their impact on detection and termination rates for Neural Tube Defects and Down’s syndrome. / Boyd, Patricia A; DeVigan, Catherine; Khoshnood, Babak; Loane, Maria; Garne, Ester; Dolk, Helen; EUROCAT, Working Group.

In: British Journal Obstetrics & Gynaecology, Vol. 115, No. 6, 05.2008, p. 689-696.

Research output: Contribution to journalArticle

TY - JOUR

T1 - Survey of prenatal screening policies in Europe for structural malformations and chromosome anomalies, and their impact on detection and termination rates for Neural Tube Defects and Down’s syndrome

AU - Boyd, Patricia A

AU - DeVigan, Catherine

AU - Khoshnood, Babak

AU - Loane, Maria

AU - Garne, Ester

AU - Dolk, Helen

AU - EUROCAT, Working Group

PY - 2008/5

Y1 - 2008/5

N2 - Objective To 'map' the current (2004) state of prenatal screening in Europe.Design (i) Survey of country policies and (ii) analysis of data from EUROCAT (European Surveillance of Congenital Anomalies) population-based congenital anomaly registers.Setting Europe.Population Survey of prenatal screening policies in 18 countries and 1.13 million births in 12 countries in 2002–04.Methods (i) Questionnaire on national screening policies and termination of pregnancy for fetal anomaly (TOPFA) laws in 2004. (ii) Analysis of data on prenatal detection and termination for Down's syndrome and neural tube defects (NTDs) using the EUROCAT database.Main outcome measures Existence of national prenatal screening policies, legal gestation limit for TOPFA, prenatal detection and termination rates for Down's syndrome and NTD.Results Ten of the 18 countries had a national country-wide policy for Down's syndrome screening and 14/18 for structural anomaly scanning. Sixty-eight percent of Down's syndrome cases (range 0–95%) were detected prenatally, of which 88% resulted in termination of pregnancy. Eighty-eight percent (range 25–94%) of cases of NTD were prenatally detected, of which 88% resulted in termination. Countries with a first-trimester screening policy had the highest proportion of prenatally diagnosed Down's syndrome cases. Countries with no official national Down's syndrome screening or structural anomaly scan policy had the lowest proportion of prenatally diagnosed Down's syndrome and NTD cases. Six of the 18 countries had a legal gestational age limit for TOPFA, and in two countries, termination of pregnancy was illegal at any gestation.Conclusions There are large differences in screening policies between countries in Europe. These, as well as organisational and cultural factors, are associated with wide country variation in prenatal detection rates for Down's syndrome and NTD.

AB - Objective To 'map' the current (2004) state of prenatal screening in Europe.Design (i) Survey of country policies and (ii) analysis of data from EUROCAT (European Surveillance of Congenital Anomalies) population-based congenital anomaly registers.Setting Europe.Population Survey of prenatal screening policies in 18 countries and 1.13 million births in 12 countries in 2002–04.Methods (i) Questionnaire on national screening policies and termination of pregnancy for fetal anomaly (TOPFA) laws in 2004. (ii) Analysis of data on prenatal detection and termination for Down's syndrome and neural tube defects (NTDs) using the EUROCAT database.Main outcome measures Existence of national prenatal screening policies, legal gestation limit for TOPFA, prenatal detection and termination rates for Down's syndrome and NTD.Results Ten of the 18 countries had a national country-wide policy for Down's syndrome screening and 14/18 for structural anomaly scanning. Sixty-eight percent of Down's syndrome cases (range 0–95%) were detected prenatally, of which 88% resulted in termination of pregnancy. Eighty-eight percent (range 25–94%) of cases of NTD were prenatally detected, of which 88% resulted in termination. Countries with a first-trimester screening policy had the highest proportion of prenatally diagnosed Down's syndrome cases. Countries with no official national Down's syndrome screening or structural anomaly scan policy had the lowest proportion of prenatally diagnosed Down's syndrome and NTD cases. Six of the 18 countries had a legal gestational age limit for TOPFA, and in two countries, termination of pregnancy was illegal at any gestation.Conclusions There are large differences in screening policies between countries in Europe. These, as well as organisational and cultural factors, are associated with wide country variation in prenatal detection rates for Down's syndrome and NTD.

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DO - 10.1111/j.1471-0528.2008.01700.x

M3 - Article

VL - 115

SP - 689

EP - 696

JO - BJOG: An International Journal of Obstetrics and Gynaecology

T2 - BJOG: An International Journal of Obstetrics and Gynaecology

JF - BJOG: An International Journal of Obstetrics and Gynaecology

SN - 1470-0328

IS - 6

ER -