Surfactants: physicochemical interactions with biological macromolecules

M Aguirre-Ramírez; H  Silva-Jimenez; Ibrahim M Banat; M. A. Diaz De Rienzo

doi:10.1007/s10529-020-03054-1

Surfactants: physicochemical interactions with biological macromolecules

M Aguirre-Ramírez, H Silva-Jimenez , Ibrahim M Banat, M. A. Diaz De Rienzo

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Abstract

Macromolecules are essential cellular components in biological systems responsible for performing a large number of functions that are necessary for growth and perseverance of living organisms. Proteins, lipids and carbohydrates are three major classes of biological macromolecules. To predict the structure, function, and behaviour of any cluster of macromolecules, it is necessary to understand the interaction between them and other components through basic principles of chemistry and physics. An important number of macromolecules are present in mixtures with surfactants, where a combination of hydrophobic and electrostatic interactions is responsible for the specific properties of any solution. It has been demonstrated that surfactants can help the formation of helices in some proteins thereby promoting protein structure formation. On the other hand, there is extensive research towards the use of surfactants to solubilize drugs and pharmaceuticals; therefore, it is evident that the interaction between surfactants with macromolecules is important for many applications which includes environmental processes and the pharmaceutical industry. In this review, we describe the properties of different types of surfactants that are relevant for their physicochemical interactions with biological macromolecules, from macromolecules–surfactant complexes to hydrophobic and electrostatic interactions.

Original language	English
Pages (from-to)	523–535
Number of pages	13
Journal	Biotechnology Letters
Volume	43
Early online date	3 Feb 2021
DOIs	https://doi.org/10.1007/s10529-020-03054-1
Publication status	Published (in print/issue) - 31 Mar 2021

Bibliographical note

Funding Information:
The authors acknowledge the funding support from the Faculty of Science, Liverpool John Moores University ECR Fellowship 2018?2019. We also acknowledge to CAC Biolog?a Celular y Molecular, Universidad Aut?noma de Ciudad Ju?rez for its host facilities.

Funding Information:
The authors acknowledge the funding support from the Faculty of Science, Liverpool John Moores University ECR Fellowship 2018–2019. We also acknowledge to CAC Biología Celular y Molecular, Universidad Autónoma de Ciudad Juárez for its host facilities. 11

Publisher Copyright:
© 2021, The Author(s).

Keywords

Surfactants Macromolecules Biological systems Molecular interactions
Macromolecules
Molecular interactions
Biological systems
Surfactants

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

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Published Aguirre-Ramírez2021_Article_SurfactantsPhysicochemicalInteFinal published version, 742 KBLicence: CC BY

Cite this

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abstract = "Macromolecules are essential cellular components in biological systems responsible for performing a large number of functions that are necessary for growth and perseverance of living organisms. Proteins, lipids and carbohydrates are three major classes of biological macromolecules. To predict the structure, function, and behaviour of any cluster of macromolecules, it is necessary to understand the interaction between them and other components through basic principles of chemistry and physics. An important number of macromolecules are present in mixtures with surfactants, where a combination of hydrophobic and electrostatic interactions is responsible for the specific properties of any solution. It has been demonstrated that surfactants can help the formation of helices in some proteins thereby promoting protein structure formation. On the other hand, there is extensive research towards the use of surfactants to solubilize drugs and pharmaceuticals; therefore, it is evident that the interaction between surfactants with macromolecules is important for many applications which includes environmental processes and the pharmaceutical industry. In this review, we describe the properties of different types of surfactants that are relevant for their physicochemical interactions with biological macromolecules, from macromolecules–surfactant complexes to hydrophobic and electrostatic interactions.",

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note = "Funding Information: The authors acknowledge the funding support from the Faculty of Science, Liverpool John Moores University ECR Fellowship 2018?2019. We also acknowledge to CAC Biolog?a Celular y Molecular, Universidad Aut?noma de Ciudad Ju?rez for its host facilities. Funding Information: The authors acknowledge the funding support from the Faculty of Science, Liverpool John Moores University ECR Fellowship 2018–2019. We also acknowledge to CAC Biolog{\'i}a Celular y Molecular, Universidad Aut{\'o}noma de Ciudad Ju{\'a}rez for its host facilities. 11 Publisher Copyright: {\textcopyright} 2021, The Author(s).",

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Surfactants: physicochemical interactions with biological macromolecules

Abstract

Bibliographical note

Keywords

UN SDGs

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