SUBSTANCE-P, NEUROKININ-A AND CALCITONIN GENE-RELATED PEPTIDE DURING DEVELOPMENT OF THE RAT GASTROINTESTINAL-TRACT

Peter Flatt, SK Swanstonflatt, CJ Bailey, GP McGregor, JM Conlon

Research output: Contribution to journalArticle

18 Citations (Scopus)

Abstract

Substance P, neurokinin A and calcitonin gene-related peptide (CGRP) were determined in the stomach and small intestine of rats during late foetal development and up to 35 days postnatal life. Concentrations of substance P in stomach and intestine increased from 14 gestational days to 3 days postpartum, and declined thereafter. Concentrations of neurokinin A in stomach declined from 14 days gestation over the period 3-35 postnatal days. In the intestine, concentrations of neurokinin A increased steadily from 14 days gestation to 21-35 postnatal days. Concentrations of CGRP in stomach and intestine declined from 14 days gestation to 7 postnatal days. Thereafter, concentrations of CGRP increased in both stomach and intestine. Total contents of each of the three peptides increased progressively with gestational and postnatal age in parallel with increasing stomach and intestinal weights. The results demonstrate different patterns of change in the concentrations of substance P, neurokinin A and CGRP during the dynamic phases of growth and maturation of the gastrointestinal tract in the foetal and postnatal rat.
Original languageEnglish
Pages (from-to)313-320
JournalRegulatory Peptides
Volume33
Issue number3
Publication statusPublished - May 1991

Fingerprint Dive into the research topics of 'SUBSTANCE-P, NEUROKININ-A AND CALCITONIN GENE-RELATED PEPTIDE DURING DEVELOPMENT OF THE RAT GASTROINTESTINAL-TRACT'. Together they form a unique fingerprint.

  • Cite this