Structural Probes in Quadruplex Nucleic Acid StructureDetermination by NMR

Ioannis Karsisiotis; Mateus Webba da Silva

doi:10.3390/molecules171113073

Structural Probes in Quadruplex Nucleic Acid StructureDetermination by NMR

Ioannis Karsisiotis
, Mateus Webba da Silva

Research output: Contribution to journal › Article › peer-review

20 Citations (Scopus)

Abstract

Traditionally, isotope-labelled DNA and RNA have been fundamental to nucleicacid structural studies by NMR. Four-stranded nucleic acid architectures studiesincreasingly benefit from a plethora of nucleotide conjugates for resonance assignments,the identification of hydrogen bond alignments, and improving the population of preferredspecies within equilibria. In this paper, we review their use for these purposes. Mostimportantly we identify reasons for the failure of some modifications to result inquadruplex formation.

Original language	English
Pages (from-to)	13073-13086
Journal	Molecules
Volume	17
DOIs	https://doi.org/10.3390/molecules171113073
Publication status	Published (in print/issue) - 2012

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

SDG 3 Good Health and Well-being

Access to Document

10.3390/molecules171113073

Cite this

@article{ddf0bec329354081b767fb99374a3e7a,

title = "Structural Probes in Quadruplex Nucleic Acid StructureDetermination by NMR",

abstract = "Traditionally, isotope-labelled DNA and RNA have been fundamental to nucleicacid structural studies by NMR. Four-stranded nucleic acid architectures studiesincreasingly benefit from a plethora of nucleotide conjugates for resonance assignments,the identification of hydrogen bond alignments, and improving the population of preferredspecies within equilibria. In this paper, we review their use for these purposes. Mostimportantly we identify reasons for the failure of some modifications to result inquadruplex formation.",

author = "Ioannis Karsisiotis and \{Webba da Silva\}, Mateus",

year = "2012",

doi = "10.3390/molecules171113073",

language = "English",

volume = "17",

pages = "13073--13086",

journal = "Molecules",

issn = "1420-3049",

publisher = "Multidisciplinary Digital Publishing Institute",

}

TY - JOUR

T1 - Structural Probes in Quadruplex Nucleic Acid StructureDetermination by NMR

AU - Karsisiotis, Ioannis

AU - Webba da Silva, Mateus

PY - 2012

Y1 - 2012

N2 - Traditionally, isotope-labelled DNA and RNA have been fundamental to nucleicacid structural studies by NMR. Four-stranded nucleic acid architectures studiesincreasingly benefit from a plethora of nucleotide conjugates for resonance assignments,the identification of hydrogen bond alignments, and improving the population of preferredspecies within equilibria. In this paper, we review their use for these purposes. Mostimportantly we identify reasons for the failure of some modifications to result inquadruplex formation.

AB - Traditionally, isotope-labelled DNA and RNA have been fundamental to nucleicacid structural studies by NMR. Four-stranded nucleic acid architectures studiesincreasingly benefit from a plethora of nucleotide conjugates for resonance assignments,the identification of hydrogen bond alignments, and improving the population of preferredspecies within equilibria. In this paper, we review their use for these purposes. Mostimportantly we identify reasons for the failure of some modifications to result inquadruplex formation.

U2 - 10.3390/molecules171113073

DO - 10.3390/molecules171113073

M3 - Article

SN - 1420-3049

VL - 17

SP - 13073

EP - 13086

JO - Molecules

JF - Molecules

ER -

Structural Probes in Quadruplex Nucleic Acid StructureDetermination by NMR

Abstract

UN SDGs

Access to Document

Fingerprint

Cite this