Structural Probes in Quadruplex Nucleic Acid StructureDetermination by NMR

Ioannis Karsisiotis, Mateus Webba da Silva

Research output: Contribution to journalArticle

14 Citations (Scopus)

Abstract

Traditionally, isotope-labelled DNA and RNA have been fundamental to nucleicacid structural studies by NMR. Four-stranded nucleic acid architectures studiesincreasingly benefit from a plethora of nucleotide conjugates for resonance assignments,the identification of hydrogen bond alignments, and improving the population of preferredspecies within equilibria. In this paper, we review their use for these purposes. Mostimportantly we identify reasons for the failure of some modifications to result inquadruplex formation.
LanguageEnglish
Pages13073-13086
JournalMolecules
Volume17
DOIs
Publication statusPublished - 2012

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nucleotides
nucleic acids
Isotopes
Nucleic Acids
Hydrogen
Hydrogen bonds
Nucleotides
deoxyribonucleic acid
isotopes
alignment
Nuclear magnetic resonance
RNA
hydrogen bonds
nuclear magnetic resonance
probes
DNA
Population

Cite this

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Structural Probes in Quadruplex Nucleic Acid StructureDetermination by NMR. / Karsisiotis, Ioannis; Webba da Silva, Mateus.

In: Molecules, Vol. 17, 2012, p. 13073-13086.

Research output: Contribution to journalArticle

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