TY - JOUR
T1 - Structural Probes in Quadruplex Nucleic Acid StructureDetermination by NMR
AU - Karsisiotis, Ioannis
AU - Webba da Silva, Mateus
PY - 2012
Y1 - 2012
N2 - Traditionally, isotope-labelled DNA and RNA have been fundamental to nucleicacid structural studies by NMR. Four-stranded nucleic acid architectures studiesincreasingly benefit from a plethora of nucleotide conjugates for resonance assignments,the identification of hydrogen bond alignments, and improving the population of preferredspecies within equilibria. In this paper, we review their use for these purposes. Mostimportantly we identify reasons for the failure of some modifications to result inquadruplex formation.
AB - Traditionally, isotope-labelled DNA and RNA have been fundamental to nucleicacid structural studies by NMR. Four-stranded nucleic acid architectures studiesincreasingly benefit from a plethora of nucleotide conjugates for resonance assignments,the identification of hydrogen bond alignments, and improving the population of preferredspecies within equilibria. In this paper, we review their use for these purposes. Mostimportantly we identify reasons for the failure of some modifications to result inquadruplex formation.
U2 - 10.3390/molecules171113073
DO - 10.3390/molecules171113073
M3 - Article
SN - 1420-3049
VL - 17
SP - 13073
EP - 13086
JO - Molecules
JF - Molecules
ER -
