Structural Probes in Quadruplex Nucleic Acid StructureDetermination by NMR

Ioannis Karsisiotis, Mateus Webba da Silva

Research output: Contribution to journalArticlepeer-review

17 Citations (Scopus)


Traditionally, isotope-labelled DNA and RNA have been fundamental to nucleicacid structural studies by NMR. Four-stranded nucleic acid architectures studiesincreasingly benefit from a plethora of nucleotide conjugates for resonance assignments,the identification of hydrogen bond alignments, and improving the population of preferredspecies within equilibria. In this paper, we review their use for these purposes. Mostimportantly we identify reasons for the failure of some modifications to result inquadruplex formation.
Original languageEnglish
Pages (from-to)13073-13086
Publication statusPublished (in print/issue) - 2012


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