Abstract
Four peptides derived from procalcitonin were isolated in high yield from a extract of a human medullary thyroid carcinoma. The peptides were identified as procalcitonin-(1-57)-peptide, procalcitonin-(60-91)-peptide (calcitonin), procalcitonin-(60-116)-peptide and procalcitonin-(96-116)-peptide (katacalcin). Determination of the amino acid sequence of procalcitonin-(1-57)-peptide has demonstrated that the Ala25-Ala26 bond in preprocalcitonin is the site of cleavage of the signal peptide. Procalcitonin-(60-116)-peptide represents calcitonin extended from its C-terminus by the sequence Gly-Lys-Lys-Arg-katacalcin, and its formation is indicative of an aberrant pathway of procalcitonin processing in the tumour cells.
Original language | English |
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Pages (from-to) | 245-250 |
Number of pages | 6 |
Journal | Biochemical Journal |
Volume | 256 |
Issue number | 1 |
DOIs | |
Publication status | Published (in print/issue) - 1988 |