Streptomyces Isolates from the Soil of an Ancient Irish Cure Site, Capable of Inhibiting Multi-Resistant Bacteria and Yeasts

Gerry A. Quinn, Alyaa M. Abdelhameed, Aiya Banat, Nada Alharbi, Laura Baker, Helena Carlo Castro, Paul J Dyson, Paul D Fancy , Diego Cobice, Luciana Terra, Simms Adu, Martin T Swain, Ibrahim M Banat

Research output: Contribution to journalArticlepeer-review

5 Citations (Scopus)
41 Downloads (Pure)


Traditional Irish medicines are often intertwined with ritual and spirituality, making it difficult to substantiate the validity of their claims. In this manuscript, we use molecular and microscopic techniques to investigate some microorganisms that might be responsible for the reputed healing properties of an ancient Irish soil cure known as the Blessed clay from a site in Boho in the West Fermanagh Scarplands. We previously reported the isolation of an antibiotic producing bacteria from this soil. In this report, we characterize the antibiotic activity of a further six isolates of Streptomyces from this source. Two of these isolates inhibit the growth of multi-resistant Staphylococcus aureus (MRSA) and Pseudomonas aeruginosa, two inhibit the growth of the yeast Starmerella bombicola, and two have as yet undetermined activity. Genetic analysis of these Streptomyces reveals the potential to synthesize varieties of antibiotics similar to cypemycin, griseochelin, macrolactams, and candicidin. From these observations, we suggest that part of the medicinal reputation of the Blessed clay may lie in the diversity of antimicrobial producing Streptomyces isolated from this soil. These findings highlight the potential for antibiotic discovery in this area.
Original languageEnglish
Article number4923
Number of pages11
JournalApplied Sciences
Issue number11
Publication statusPublished (in print/issue) - 27 May 2021

Bibliographical note

Funding Information:
This work was financed through the kind donations of time and equipment by colleagues in Ulster University, Swansea University, The Ruder Boskovic Institute, and contributions from Julie Martellini, Helena Bilandzija, Lidia Vila, Vera Alexandra, Zepur Agopyan, Marijana Bakovifa, and Janette Baldrick.

Publisher Copyright:
© 2021 by the authors. Licensee MDPI, Basel, Switzerland.


  • Antibiotics
  • Antimicrobial
  • Ethnopharmacology
  • MRSA
  • Soil
  • Streptomyces
  • Traditional medicine


Dive into the research topics of 'Streptomyces Isolates from the Soil of an Ancient Irish Cure Site, Capable of Inhibiting Multi-Resistant Bacteria and Yeasts'. Together they form a unique fingerprint.

Cite this