Strategies to reduce the wearing time of cabotegravir sodium dissolving microarray pacthes by facilitating fast tip detachment from the baseplate

Fabiana Volpe-Zanutto; Lalitkumar V. Kumar; Ismaiel Tekko; Courtney Jarrahian; Ryan F Donnelly

doi:10.5920/bjpharm.1083

Strategies to reduce the wearing time of cabotegravir sodium dissolving microarray pacthes by facilitating fast tip detachment from the baseplate

Fabiana Volpe-Zanutto
, Lalitkumar V. Kumar
, Ismaiel Tekko
, Courtney Jarrahian
, Ryan F Donnelly

Research output: Contribution to journal › Article › peer-review

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Abstract

Dissolving microarray patches (DMAP) contain micron-scale projections and are usually made from biocompatible water-soluble polymers containing a high amount of drug in their tips, to be delivered through the skin layers. The challenge regarding DMAP is the detachment of the tips from the baseplate. & nbsp; This impacts the wearing time, the delivery efficiency of the skin, and patient compliance. In our previous work, we reported the delivery of cabotegravir sodium (CAB Na), an anti-HIV drug, necessitting the wearing time of more than 1 hour [1].Herein we developed strategies to reduce the wearing time of DMAP containing cabotegravir sodium from hours to 10 minutes by facilitating tip detachment from the baseplate.

Original language	English
Article number	1083
Pages (from-to)	1-2
Number of pages	2
Journal	British Journal of Pharmacy
Volume	7
Issue number	2
Early online date	4 Nov 2022
DOIs	https://doi.org/10.5920/bjpharm.1083
Publication status	Published online - 4 Nov 2022
Event	13th Academy of Pharmaceutical Sciences PharmSci International Conference 2022 - Belfast, United Kingdom Duration: 7 Sept 2022 → 9 Sept 2022 Conference number: 2022 https://www.apsgb.co.uk/event/pharmsci-international-conference-belfast/

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

SDG 3 Good Health and Well-being

Keywords

Management Science and Operations Research
Mechanical Engineering
Energy Engineering and Power Technology

Access to Document

10.5920/bjpharm.1083

bjpharm-1083-volpe-zanuttoFinal published version, 397 KBLicence: CC BY

Cite this

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title = "Strategies to reduce the wearing time of cabotegravir sodium dissolving microarray pacthes by facilitating fast tip detachment from the baseplate",

abstract = "Dissolving microarray patches (DMAP) contain micron-scale projections and are usually made from biocompatible water-soluble polymers containing a high amount of drug in their tips, to be delivered through the skin layers. The challenge regarding DMAP is the detachment of the tips from the baseplate. \& nbsp; This impacts the wearing time, the delivery efficiency of the skin, and patient compliance. In our previous work, we reported the delivery of cabotegravir sodium (CAB Na), an anti-HIV drug, necessitting the wearing time of more than 1 hour [1].Herein we developed strategies to reduce the wearing time of DMAP containing cabotegravir sodium from hours to 10 minutes by facilitating tip detachment from the baseplate.",

keywords = "Management Science and Operations Research, Mechanical Engineering, Energy Engineering and Power Technology",

author = "Fabiana Volpe-Zanutto and Kumar, \{Lalitkumar V.\} and Ismaiel Tekko and Courtney Jarrahian and Donnelly, \{Ryan F\}",

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AU - Volpe-Zanutto, Fabiana

AU - Kumar, Lalitkumar V.

AU - Tekko, Ismaiel

AU - Jarrahian, Courtney

AU - Donnelly, Ryan F

N1 - Conference code: 2022

PY - 2022/11/4

Y1 - 2022/11/4

N2 - Dissolving microarray patches (DMAP) contain micron-scale projections and are usually made from biocompatible water-soluble polymers containing a high amount of drug in their tips, to be delivered through the skin layers. The challenge regarding DMAP is the detachment of the tips from the baseplate. & nbsp; This impacts the wearing time, the delivery efficiency of the skin, and patient compliance. In our previous work, we reported the delivery of cabotegravir sodium (CAB Na), an anti-HIV drug, necessitting the wearing time of more than 1 hour [1].Herein we developed strategies to reduce the wearing time of DMAP containing cabotegravir sodium from hours to 10 minutes by facilitating tip detachment from the baseplate.

AB - Dissolving microarray patches (DMAP) contain micron-scale projections and are usually made from biocompatible water-soluble polymers containing a high amount of drug in their tips, to be delivered through the skin layers. The challenge regarding DMAP is the detachment of the tips from the baseplate. & nbsp; This impacts the wearing time, the delivery efficiency of the skin, and patient compliance. In our previous work, we reported the delivery of cabotegravir sodium (CAB Na), an anti-HIV drug, necessitting the wearing time of more than 1 hour [1].Herein we developed strategies to reduce the wearing time of DMAP containing cabotegravir sodium from hours to 10 minutes by facilitating tip detachment from the baseplate.

KW - Management Science and Operations Research

KW - Mechanical Engineering

KW - Energy Engineering and Power Technology

UR - https://www.apsgb.co.uk/event/pharmsci-international-conference-belfast/

U2 - 10.5920/bjpharm.1083

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T2 - 13th Academy of Pharmaceutical Sciences PharmSci International Conference 2022

Y2 - 7 September 2022 through 9 September 2022

ER -

Strategies to reduce the wearing time of cabotegravir sodium dissolving microarray pacthes by facilitating fast tip detachment from the baseplate

Abstract

UN SDGs

Keywords

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