TY - JOUR
T1 - Stimulation of insulin secretion in clonal BRIN-BD11 cells by the imidazoline derivatives KU14R and RX801080
AU - Ball, AJ
AU - Flatt, Peter
AU - McClenaghan, Neville
PY - 2000/12
Y1 - 2000/12
N2 - The imidazoline derivatives KU14R and RX801080 have each been reported to antagonize imidazoline-stimulated insulin secretion. This study investigated the effects of a range of concentrations of both KU14R and RX801080 on insulin secretion from the clonal pancreatic beta cell line, BRIN-BD11, In the presence of a stimulatory (8.4 mM) glucose concentration, both KU14R (50-200 muM; PmuM; P <0.001). This secretagogue action was augmented both by KU14R (25-200 muM; P <0.001) and by RX801080 (25-200 mUM; P
AB - The imidazoline derivatives KU14R and RX801080 have each been reported to antagonize imidazoline-stimulated insulin secretion. This study investigated the effects of a range of concentrations of both KU14R and RX801080 on insulin secretion from the clonal pancreatic beta cell line, BRIN-BD11, In the presence of a stimulatory (8.4 mM) glucose concentration, both KU14R (50-200 muM; PmuM; P <0.001). This secretagogue action was augmented both by KU14R (25-200 muM; P <0.001) and by RX801080 (25-200 mUM; P
UR - https://www.scopus.com/pages/publications/0033709470
M3 - Article
VL - 42
SP - 575
EP - 579
JO - Pharmacological Research
JF - Pharmacological Research
IS - 6
ER -