Stimulation of insulin secretion in clonal BRIN-BD11 cells by the imidazoline derivatives KU14R and RX801080

AJ Ball, Peter Flatt, Neville McClenaghan

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The imidazoline derivatives KU14R and RX801080 have each been reported to antagonize imidazoline-stimulated insulin secretion. This study investigated the effects of a range of concentrations of both KU14R and RX801080 on insulin secretion from the clonal pancreatic beta cell line, BRIN-BD11, In the presence of a stimulatory (8.4 mM) glucose concentration, both KU14R (50-200 muM; PmuM; P <0.001). This secretagogue action was augmented both by KU14R (25-200 muM; P <0.001) and by RX801080 (25-200 mUM; P
Original languageEnglish
Pages (from-to)575-579
JournalPharmacological Research
Issue number6
Publication statusPublished - Dec 2000


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