Stimulation of insulin secretion in clonal BRIN-BD11 cells by the imidazoline derivatives KU14R and RX801080

AJ Ball, Peter Flatt, Neville McClenaghan

Research output: Contribution to journalArticle

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Abstract

The imidazoline derivatives KU14R and RX801080 have each been reported to antagonize imidazoline-stimulated insulin secretion. This study investigated the effects of a range of concentrations of both KU14R and RX801080 on insulin secretion from the clonal pancreatic beta cell line, BRIN-BD11, In the presence of a stimulatory (8.4 mM) glucose concentration, both KU14R (50-200 muM; PmuM; P <0.001). This secretagogue action was augmented both by KU14R (25-200 muM; P <0.001) and by RX801080 (25-200 mUM; P
LanguageEnglish
Pages575-579
JournalPharmacological Research
Volume42
Issue number6
Publication statusPublished - Dec 2000

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S 9871
Imidazolines
Insulin
Insulin-Secreting Cells
Glucose
Cell Line
KU 14R

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abstract = "The imidazoline derivatives KU14R and RX801080 have each been reported to antagonize imidazoline-stimulated insulin secretion. This study investigated the effects of a range of concentrations of both KU14R and RX801080 on insulin secretion from the clonal pancreatic beta cell line, BRIN-BD11, In the presence of a stimulatory (8.4 mM) glucose concentration, both KU14R (50-200 muM; PmuM; P <0.001). This secretagogue action was augmented both by KU14R (25-200 muM; P <0.001) and by RX801080 (25-200 mUM; P",
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Stimulation of insulin secretion in clonal BRIN-BD11 cells by the imidazoline derivatives KU14R and RX801080. / Ball, AJ; Flatt, Peter; McClenaghan, Neville.

In: Pharmacological Research, Vol. 42, No. 6, 12.2000, p. 575-579.

Research output: Contribution to journalArticle

TY - JOUR

T1 - Stimulation of insulin secretion in clonal BRIN-BD11 cells by the imidazoline derivatives KU14R and RX801080

AU - Ball, AJ

AU - Flatt, Peter

AU - McClenaghan, Neville

PY - 2000/12

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N2 - The imidazoline derivatives KU14R and RX801080 have each been reported to antagonize imidazoline-stimulated insulin secretion. This study investigated the effects of a range of concentrations of both KU14R and RX801080 on insulin secretion from the clonal pancreatic beta cell line, BRIN-BD11, In the presence of a stimulatory (8.4 mM) glucose concentration, both KU14R (50-200 muM; PmuM; P <0.001). This secretagogue action was augmented both by KU14R (25-200 muM; P <0.001) and by RX801080 (25-200 mUM; P

AB - The imidazoline derivatives KU14R and RX801080 have each been reported to antagonize imidazoline-stimulated insulin secretion. This study investigated the effects of a range of concentrations of both KU14R and RX801080 on insulin secretion from the clonal pancreatic beta cell line, BRIN-BD11, In the presence of a stimulatory (8.4 mM) glucose concentration, both KU14R (50-200 muM; PmuM; P <0.001). This secretagogue action was augmented both by KU14R (25-200 muM; P <0.001) and by RX801080 (25-200 mUM; P

M3 - Article

VL - 42

SP - 575

EP - 579

JO - Pharmacological Research

T2 - Pharmacological Research

JF - Pharmacological Research

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