Stimulation of insulin secretion in clonal BRIN-BD11 cells by the imidazoline derivatives KU14R and RX801080

AJ Ball; Peter Flatt; Neville McClenaghan

Stimulation of insulin secretion in clonal BRIN-BD11 cells by the imidazoline derivatives KU14R and RX801080

AJ Ball, Peter Flatt, Neville McClenaghan

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Abstract

The imidazoline derivatives KU14R and RX801080 have each been reported to antagonize imidazoline-stimulated insulin secretion. This study investigated the effects of a range of concentrations of both KU14R and RX801080 on insulin secretion from the clonal pancreatic beta cell line, BRIN-BD11, In the presence of a stimulatory (8.4 mM) glucose concentration, both KU14R (50-200 muM; PmuM; P <0.001). This secretagogue action was augmented both by KU14R (25-200 muM; P <0.001) and by RX801080 (25-200 mUM; P

Original language	English
Pages (from-to)	575-579
Journal	Pharmacological Research
Volume	42
Issue number	6
Publication status	Published (in print/issue) - Dec 2000

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title = "Stimulation of insulin secretion in clonal BRIN-BD11 cells by the imidazoline derivatives KU14R and RX801080",

abstract = "The imidazoline derivatives KU14R and RX801080 have each been reported to antagonize imidazoline-stimulated insulin secretion. This study investigated the effects of a range of concentrations of both KU14R and RX801080 on insulin secretion from the clonal pancreatic beta cell line, BRIN-BD11, In the presence of a stimulatory (8.4 mM) glucose concentration, both KU14R (50-200 muM; PmuM; P <0.001). This secretagogue action was augmented both by KU14R (25-200 muM; P <0.001) and by RX801080 (25-200 mUM; P",

author = "AJ Ball and Peter Flatt and Neville McClenaghan",

year = "2000",

month = dec,

language = "English",

volume = "42",

pages = "575--579",

journal = "Pharmacological Research",

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T1 - Stimulation of insulin secretion in clonal BRIN-BD11 cells by the imidazoline derivatives KU14R and RX801080

AU - Ball, AJ

AU - Flatt, Peter

AU - McClenaghan, Neville

PY - 2000/12

Y1 - 2000/12

N2 - The imidazoline derivatives KU14R and RX801080 have each been reported to antagonize imidazoline-stimulated insulin secretion. This study investigated the effects of a range of concentrations of both KU14R and RX801080 on insulin secretion from the clonal pancreatic beta cell line, BRIN-BD11, In the presence of a stimulatory (8.4 mM) glucose concentration, both KU14R (50-200 muM; PmuM; P <0.001). This secretagogue action was augmented both by KU14R (25-200 muM; P <0.001) and by RX801080 (25-200 mUM; P

AB - The imidazoline derivatives KU14R and RX801080 have each been reported to antagonize imidazoline-stimulated insulin secretion. This study investigated the effects of a range of concentrations of both KU14R and RX801080 on insulin secretion from the clonal pancreatic beta cell line, BRIN-BD11, In the presence of a stimulatory (8.4 mM) glucose concentration, both KU14R (50-200 muM; PmuM; P <0.001). This secretagogue action was augmented both by KU14R (25-200 muM; P <0.001) and by RX801080 (25-200 mUM; P

M3 - Article

VL - 42

SP - 575

EP - 579

JO - Pharmacological Research

JF - Pharmacological Research

IS - 6

ER -

Stimulation of insulin secretion in clonal BRIN-BD11 cells by the imidazoline derivatives KU14R and RX801080

Abstract

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