Stable increased formulation atomization using a multi-tip nozzle device

Rita Haj-Ahmad, Manoochehr Rasekh, Kazem Nazari, Ekhoerose V. Onaiwu, Bushra Yousef, Stuart Morgan, David Evans, Ming Wei Chang, John Hall, Chris Samwell, Zeeshan Ahmad

Research output: Contribution to journalArticle

3 Citations (Scopus)

Abstract

Electrohydrodynamic atomization (EHDA) is an emerging technique for the production of micron and nano-scaled particles. The process often involves Taylor cone enablement, which results in a fine spray yielding formulated droplets, which then undergo drying during deposition. In this work, novel multi-tip emitter (MTE) devices were designed, engineered and utilized for potential up-scaled EHDA, by comparison with a conventional single-needle system. To demonstrate this, the active ketoprofen (KETO) was formulated using polyvinylpyrrolidone (PVP) polymer as the matrix material. Here, PVP polymer (5% w/v) solution was prepared using ethanol and distilled water (80:20) as the vehicle. KETO was incorporated as 5% w/w of PVP. Physical properties of resulting solutions (viscosity, electrical conductivity, density and surface tension) were obtained. Formulations were electrosprayed through both single and novel MTEs under EHDA conditions at various flow rates (5–300 μl/min) and applied voltages (0–30 kV). The atomization process using MTEs and single nozzle was monitored at using various process parameters via a digital optical camera. Resulting particles were collected 200 mm below processing heads and were analyzed using differential scanning calorimetry (DSC), thermal gravimetric analysis (TGA), X-ray diffraction (XRD) and scanning electron microscopy (SEM). Digital recordings confirmed stable MTE jetting at higher flow rates. Electron micrographs confirmed particle size variation arising due to nozzle head design and evidenced stable jetting derived greater near-uniform particles. DSC, XRD and TGA confirm KETO molecules were encapsulated and dispersed into PVP polymer particles. In conclusion, novel MTE devices enabled stable atomization even at higher flow rates when compared to conventional single-needle device. This indicates an exciting approach for scaling up (EHDA) in contrast to current efforts focusing on multiple-nozzle and pore-based processing outlets.

Original languageEnglish
Pages (from-to)1815-1827
Number of pages13
JournalDrug Delivery and Translational Research
Volume8
Issue number6
Early online date5 Jun 2018
DOIs
Publication statusPublished - 15 Dec 2018

Keywords

  • Electrohydrodynamic
  • Electrospraying
  • Encapsulation
  • Jetting
  • Microparticles
  • Multi-tip emitter (MTE)
  • Nanoparticles

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  • Cite this

    Haj-Ahmad, R., Rasekh, M., Nazari, K., Onaiwu, E. V., Yousef, B., Morgan, S., Evans, D., Chang, M. W., Hall, J., Samwell, C., & Ahmad, Z. (2018). Stable increased formulation atomization using a multi-tip nozzle device. Drug Delivery and Translational Research, 8(6), 1815-1827. https://doi.org/10.1007/s13346-018-0518-4