SOMATOSTATIN, GASTRIN-RELEASING PEPTIDE AND GASTRIN IN THE STOMACH OF RATS WITH STREPTOZOTOCIN-INDUCED DIABETES AND INSULINOMA

Research output: Contribution to journalArticle

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Abstract

Somatostatin, gastrin-releasing peptide (GRP) and gastrin were measured in the stomach of rats with streptozotocin-induced diabetes, insulinoma-bearing rats and their respective controls. Rats injected with streptozotocin exhibited hyperphagia, insulinopenia and severe hyperglycemia. Stomach weights, and the concentrations and total amounts of GRP and gastrin in the stomach, were similar to nondiabetic control rats. The concentration of somatostatin in the stomach of diabetic rats was 25% greater, but the total stomach content of somatostatin was similar to that of control rats. Insulinoma-bearing rats exhibited hyperphagia, hyperinsulinemia and hypoglycemia. Concentrations of GRP and gastrin in the stomach were 72% and 19% lower, respectively, than in control rats. Despite 45% greater stomach weight, the total stomach content of GRP was 61% lower. Stomach concentrations of somatostatin, and total stomach contents of somatostatin and gastrin, were similar in insulinoma-bearing and control rats. The results demonstrate abnormalities in the stomach concentrations of regulatory peptides in rats with diabetes and insulinoma. These abnormalities are not attributable to changes in food intake alone, suggesting specific effects of these metabolic diseases on gastric regulatory peptides and gastric function.
LanguageEnglish
Pages1414-1417
JournalJournal of Nutrition
Volume121
Issue number9
Publication statusPublished - Sep 1991

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Gastrin-Releasing Peptide
Insulinoma
Experimental Diabetes Mellitus
Gastrins
Somatostatin
Stomach
Gastrointestinal Contents
Hyperphagia
Weights and Measures
Peptides
Metabolic Diseases
Hyperinsulinism
Streptozocin
Hypoglycemia
Hyperglycemia
Eating

Cite this

@article{21ee5a07e985486dade58fe0384f5e27,
title = "SOMATOSTATIN, GASTRIN-RELEASING PEPTIDE AND GASTRIN IN THE STOMACH OF RATS WITH STREPTOZOTOCIN-INDUCED DIABETES AND INSULINOMA",
abstract = "Somatostatin, gastrin-releasing peptide (GRP) and gastrin were measured in the stomach of rats with streptozotocin-induced diabetes, insulinoma-bearing rats and their respective controls. Rats injected with streptozotocin exhibited hyperphagia, insulinopenia and severe hyperglycemia. Stomach weights, and the concentrations and total amounts of GRP and gastrin in the stomach, were similar to nondiabetic control rats. The concentration of somatostatin in the stomach of diabetic rats was 25{\%} greater, but the total stomach content of somatostatin was similar to that of control rats. Insulinoma-bearing rats exhibited hyperphagia, hyperinsulinemia and hypoglycemia. Concentrations of GRP and gastrin in the stomach were 72{\%} and 19{\%} lower, respectively, than in control rats. Despite 45{\%} greater stomach weight, the total stomach content of GRP was 61{\%} lower. Stomach concentrations of somatostatin, and total stomach contents of somatostatin and gastrin, were similar in insulinoma-bearing and control rats. The results demonstrate abnormalities in the stomach concentrations of regulatory peptides in rats with diabetes and insulinoma. These abnormalities are not attributable to changes in food intake alone, suggesting specific effects of these metabolic diseases on gastric regulatory peptides and gastric function.",
author = "Peter Flatt and CJ Bailey and JM Conlon",
year = "1991",
month = "9",
language = "English",
volume = "121",
pages = "1414--1417",
journal = "Journal of Nutrition",
issn = "0022-3166",
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SOMATOSTATIN, GASTRIN-RELEASING PEPTIDE AND GASTRIN IN THE STOMACH OF RATS WITH STREPTOZOTOCIN-INDUCED DIABETES AND INSULINOMA. / Flatt, Peter; Bailey, CJ; Conlon, JM.

In: Journal of Nutrition, Vol. 121, No. 9, 09.1991, p. 1414-1417.

Research output: Contribution to journalArticle

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AB - Somatostatin, gastrin-releasing peptide (GRP) and gastrin were measured in the stomach of rats with streptozotocin-induced diabetes, insulinoma-bearing rats and their respective controls. Rats injected with streptozotocin exhibited hyperphagia, insulinopenia and severe hyperglycemia. Stomach weights, and the concentrations and total amounts of GRP and gastrin in the stomach, were similar to nondiabetic control rats. The concentration of somatostatin in the stomach of diabetic rats was 25% greater, but the total stomach content of somatostatin was similar to that of control rats. Insulinoma-bearing rats exhibited hyperphagia, hyperinsulinemia and hypoglycemia. Concentrations of GRP and gastrin in the stomach were 72% and 19% lower, respectively, than in control rats. Despite 45% greater stomach weight, the total stomach content of GRP was 61% lower. Stomach concentrations of somatostatin, and total stomach contents of somatostatin and gastrin, were similar in insulinoma-bearing and control rats. The results demonstrate abnormalities in the stomach concentrations of regulatory peptides in rats with diabetes and insulinoma. These abnormalities are not attributable to changes in food intake alone, suggesting specific effects of these metabolic diseases on gastric regulatory peptides and gastric function.

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