Solid-state fermentation: a promising microbial technology for secondary metabolite production

T Robinson, D Singh, Poonam Singh - Nee Nigam

Research output: Contribution to journalArticle

152 Citations (Scopus)

Abstract

Solid state (substrate) fermentation (SSF) has been used successfully for the production of enzymes and secondary metabolites. These products are associated with the stationary phase of microbial growth and are produced on an industrial scale for use in agriculture and the treatment of disease, Many of these secondary metabolites are still produced by submerged liquid fermentations (SmF) even though production by this method has been shown to be less efficient than SSF As large-scale production increases further, so do the costs and energy demands. SSF has been shown to produce a more stable product, requiring less energy, in smaller fermenters, with easier downstream processing measures. In this article we review an important area of biotechnology, since the recent evidence indicates that bacteria and fungi, growing under SSF conditions, are more than capable of supplying the growing global demand for secondary metabolites.
LanguageEnglish
Pages284-289
JournalApplied Microbiology and Biotechnology
Volume55
Issue number3
Publication statusPublished - Apr 2001

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Fermentation
Technology
Biotechnology
Agriculture
Fungi
Bacteria
Costs and Cost Analysis
Enzymes
Growth

Cite this

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title = "Solid-state fermentation: a promising microbial technology for secondary metabolite production",
abstract = "Solid state (substrate) fermentation (SSF) has been used successfully for the production of enzymes and secondary metabolites. These products are associated with the stationary phase of microbial growth and are produced on an industrial scale for use in agriculture and the treatment of disease, Many of these secondary metabolites are still produced by submerged liquid fermentations (SmF) even though production by this method has been shown to be less efficient than SSF As large-scale production increases further, so do the costs and energy demands. SSF has been shown to produce a more stable product, requiring less energy, in smaller fermenters, with easier downstream processing measures. In this article we review an important area of biotechnology, since the recent evidence indicates that bacteria and fungi, growing under SSF conditions, are more than capable of supplying the growing global demand for secondary metabolites.",
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Solid-state fermentation: a promising microbial technology for secondary metabolite production. / Robinson, T; Singh, D; Singh - Nee Nigam, Poonam.

In: Applied Microbiology and Biotechnology, Vol. 55, No. 3, 04.2001, p. 284-289.

Research output: Contribution to journalArticle

TY - JOUR

T1 - Solid-state fermentation: a promising microbial technology for secondary metabolite production

AU - Robinson, T

AU - Singh, D

AU - Singh - Nee Nigam, Poonam

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N2 - Solid state (substrate) fermentation (SSF) has been used successfully for the production of enzymes and secondary metabolites. These products are associated with the stationary phase of microbial growth and are produced on an industrial scale for use in agriculture and the treatment of disease, Many of these secondary metabolites are still produced by submerged liquid fermentations (SmF) even though production by this method has been shown to be less efficient than SSF As large-scale production increases further, so do the costs and energy demands. SSF has been shown to produce a more stable product, requiring less energy, in smaller fermenters, with easier downstream processing measures. In this article we review an important area of biotechnology, since the recent evidence indicates that bacteria and fungi, growing under SSF conditions, are more than capable of supplying the growing global demand for secondary metabolites.

AB - Solid state (substrate) fermentation (SSF) has been used successfully for the production of enzymes and secondary metabolites. These products are associated with the stationary phase of microbial growth and are produced on an industrial scale for use in agriculture and the treatment of disease, Many of these secondary metabolites are still produced by submerged liquid fermentations (SmF) even though production by this method has been shown to be less efficient than SSF As large-scale production increases further, so do the costs and energy demands. SSF has been shown to produce a more stable product, requiring less energy, in smaller fermenters, with easier downstream processing measures. In this article we review an important area of biotechnology, since the recent evidence indicates that bacteria and fungi, growing under SSF conditions, are more than capable of supplying the growing global demand for secondary metabolites.

M3 - Article

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SP - 284

EP - 289

JO - Applied Microbiology and Biotechnology

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