Slower speed of blood pressure recovery after standing is associated with accelerated brain aging: Evidence from The Irish Longitudinal Study on Ageing (TILDA)

Morgana A Shirsath, John D O'Connor, Rory Boyle, Louise Newman, Silvin P Knight, Belinda Hernandez, Robert Whelan, James F Meaney, Rose Anne Kenny

Research output: Contribution to journalArticlepeer-review

Abstract

Impaired recovery of blood pressure (BP) in response to standing up is a prevalent condition in older individuals. We evaluated the relationship between the early recovery of hemodynamic responses to standing and brain health in adults over 50. Participants from The Irish Longitudinal Study on Ageing (TILDA) (n=411; age 67.6 ± 7.3 years; 53.4 % women) performed an active stand challenge while blood pressure and heart rate were continuously monitored. The recovery of these parameters was determined as the slope of the BP and HR response, following the initial drop/rise after standing. We have previously reported a novel and validated measure of brain ageing using MRI data, which measures the difference between biological brain age and chronological age, providing a brain-predicted age difference (brainPAD) score. Slower recovery of systolic and diastolic BP was found to be significantly associated with higher brainPAD scores (i.e., biologically older brains), where a one-year increase in brainPAD was associated with a decrease of 0.02 mmHg/s and 0.01 mmHg/s in systolic and diastolic BP recovery, respectively, after standing. Heart rate (HR) recovery was not significantly associated with brainPAD score. These results demonstrate that slower systolic and diastolic BP recovery in the early phase after standing is associated with accelerated brain aging in older individuals. This suggests that the BP response to standing, measured using beat-to-beat monitoring, has the potential to be used as a marker of accelerated brain aging, relying on a simple procedure and devices that are easily accessible. [Abstract copyright: © 2024 The Authors. Published by Elsevier B.V.]
Original languageEnglish
Article number100212
Pages (from-to)1-7
Number of pages8
JournalCerebral circulation - cognition and behavior
Volume6
Early online date24 Feb 2024
DOIs
Publication statusPublished online - 24 Feb 2024

Bibliographical note

© 2024 The Authors. Published by Elsevier B.V.

Data Access Statement

The data collected for this study is sensitive, requests for access should be directed to The Irish Longitudinal Study on Ageing (TILDA), Trinity Central, 152-160 Pearse St, Dublin 2, D02 R590, Republic of Ireland (email: tilda@tcd.ie).

Keywords

  • Active stand
  • Orthostatic hypotension
  • Cerebral autoregulation
  • Brain aging

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