Skeletal Muscle Stem Cells

Elisa Negroni, Maximilien Bencze, Stephanie Duguez, Gillian Butler-Browne, Vincent Mouly

    Research output: Chapter in Book/Report/Conference proceedingChapter

    Abstract

    Stem cell therapy has been envisaged for treating disorders affecting skeletal muscle tissue. The first myogenic stem cell which was proposed and used in clinical trials was the physiological muscle progenitor, i.e. the satellite cell.However, before considering intervention in skeletal muscle, one needs to know well the process of muscle regeneration, as well as the different pathologies that can be eligible for cell therapy. Here, we present an overview of muscle regeneration, the role of satellite cells, how the process is orchestrated,and a short overview on some muscular dystrophies.
    Original languageEnglish
    Title of host publicationStem Cell Biology and Regenerative Medicine
    PublisherRiver Publishers
    Pages415-429
    ISBN (Print)978-1-4614-5492-2
    Publication statusPublished - 15 Oct 2014

    Keywords

    • muscle stem cells and regeneration

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