Simplicity, Flexibility, and Interpretability in a Model of Dendritic Protein Distributions

Cian O'Donnell

doi:10.1016/j.neuron.2019.09.010

Simplicity, Flexibility, and Interpretability in a Model of Dendritic Protein Distributions

Cian O'Donnell

Research output: Contribution to journal › Article › peer-review

1 Citation (Scopus)

Abstract

In this issue of Neuron, Fonkeu et al. (2019) present a mathematical model of mRNA and protein synthesis, degradation, diffusion, and trafficking in neuronal dendrites. The model can predict the spatial distribution and temporal dynamics of proteins along dendrites. The authors use the model to account for in situ imaging data of CaMKII⍺ mRNA and protein in hippocampal neurons.

Original language	English
Pages (from-to)	950-952
Number of pages	3
Journal	Neuron
Volume	103
Issue number	6
DOIs	https://doi.org/10.1016/j.neuron.2019.09.010
Publication status	Published (in print/issue) - 25 Sept 2019

Bibliographical note

Keywords

Dendrites
Hippocampus
Neurons
Protein Biosynthesis
RNA, Messenger

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10.1016/j.neuron.2019.09.010

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abstract = "In this issue of Neuron, Fonkeu et al. (2019) present a mathematical model of mRNA and protein synthesis, degradation, diffusion, and trafficking in neuronal dendrites. The model can predict the spatial distribution and temporal dynamics of proteins along dendrites. The authors use the model to account for in situ imaging data of CaMKII⍺ mRNA and protein in hippocampal neurons.",

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AB - In this issue of Neuron, Fonkeu et al. (2019) present a mathematical model of mRNA and protein synthesis, degradation, diffusion, and trafficking in neuronal dendrites. The model can predict the spatial distribution and temporal dynamics of proteins along dendrites. The authors use the model to account for in situ imaging data of CaMKII⍺ mRNA and protein in hippocampal neurons.

KW - Dendrites

KW - Hippocampus

KW - Neurons

KW - Protein Biosynthesis

KW - RNA, Messenger

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DO - 10.1016/j.neuron.2019.09.010

M3 - Article

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JF - Neuron

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ER -

Simplicity, Flexibility, and Interpretability in a Model of Dendritic Protein Distributions

Abstract

Bibliographical note

Keywords

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