Simplicity, Flexibility, and Interpretability in a Model of Dendritic Protein Distributions

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Abstract

In this issue of Neuron, Fonkeu et al. (2019) present a mathematical model of mRNA and protein synthesis, degradation, diffusion, and trafficking in neuronal dendrites. The model can predict the spatial distribution and temporal dynamics of proteins along dendrites. The authors use the model to account for in situ imaging data of CaMKII⍺ mRNA and protein in hippocampal neurons.

Original languageEnglish
Pages (from-to)950-952
Number of pages3
JournalNeuron
Volume103
Issue number6
DOIs
Publication statusPublished (in print/issue) - 25 Sep 2019

Bibliographical note

Crown Copyright © 2019. Published by Elsevier Inc. All rights reserved.

Keywords

  • Dendrites
  • Hippocampus
  • Neurons
  • Protein Biosynthesis
  • RNA, Messenger

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