Abstract
We propose a mechanism of action for the betL* mutation which is based on DNA topology. Removing a single thymine residue from the betL σA promoter's −10 and −35 spacer results in a ‘twist’-mediated activation of transcription which accounts for the osmotolerance phenotype observed for strains expressing betL*.
Original language | English |
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Pages (from-to) | 116-119 |
Journal | Bioengineered |
Volume | 7 |
Issue number | 2 |
Early online date | 20 May 2016 |
DOIs | |
Publication status | Published online - 20 May 2016 |
Keywords
- betL*
- lux
- Listeria
- osmotolerance