Serum neurone specific enolase levels in patients with cerebral infarction

RJ Winder, RT Cunningham, IS Young, OJ O'Kane, CS McKinstry, CJ Johnston, O Dolan, SA Hawkins, SD Buchanan

    Research output: Contribution to journalArticlepeer-review


    A radioimmunoassay has been developed and used to measure serum neurone specific enolase (NSE) concentrations in 24 patients, following cerebral infarction. A significant correlation between cerebral infarct volume and maximum serum NSE concentration was observed (P= 0·047). Serum NSE was also assayed at times 24, 48, 72 and 96 h post ictus. At 72 h a significant correlation existed between serum NSE levels and infarct volume (P= 0·012), and levels appeared to be approaching statistical significance at 48 h (P=0·067). No correlation existed at 24 and 96 h. In addition serum concentrations of NSE were compared to clinical outcome as determined by the Glasgow Outcome Score. Using the Mann-Whitney U test, there was no significant difference in maximum NSE level between patients graded 1–3 on the Glasgow Outcome Score and those graded 4 and 5. However, further studies are required on a larger population to more completely assess this. NSE may prove to be a useful marker of neuronal damage in the study of stroke, with particular application in the assessment of treatment.
    Original languageEnglish
    Pages (from-to)39-39
    JournalRegulatory Peptides
    Issue number1
    Publication statusPublished (in print/issue) - 21 Aug 1990


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