A radioimmunoassay has been developed and used to measure serum neurone specific enolase (NSE) concentrations in 24 patients, following cerebral infarction. A significant correlation between cerebral infarct volume and maximum serum NSE concentration was observed (P= 0·047). Serum NSE was also assayed at times 24, 48, 72 and 96 h post ictus. At 72 h a significant correlation existed between serum NSE levels and infarct volume (P= 0·012), and levels appeared to be approaching statistical significance at 48 h (P=0·067). No correlation existed at 24 and 96 h. In addition serum concentrations of NSE were compared to clinical outcome as determined by the Glasgow Outcome Score. Using the Mann-Whitney U test, there was no significant difference in maximum NSE level between patients graded 1–3 on the Glasgow Outcome Score and those graded 4 and 5. However, further studies are required on a larger population to more completely assess this. NSE may prove to be a useful marker of neuronal damage in the study of stroke, with particular application in the assessment of treatment.
Winder, RJ., Cunningham, RT., Young, IS., O'Kane, OJ., McKinstry, CS., Johnston, CJ., Dolan, O., Hawkins, SA., & Buchanan, SD. (1990). Serum neurone specific enolase levels in patients with cerebral infarction. Regulatory Peptides, 30(1), 39-39. https://doi.org/10.1016/0167-0115(90)90142-J