Serum neurone specific enolase levels in patients with cerebral infarction

RJ Winder, RT Cunningham, IS Young, OJ O'Kane, CS McKinstry, CJ Johnston, O Dolan, SA Hawkins, SD Buchanan

    Research output: Contribution to journalArticle

    Abstract

    A radioimmunoassay has been developed and used to measure serum neurone specific enolase (NSE) concentrations in 24 patients, following cerebral infarction. A significant correlation between cerebral infarct volume and maximum serum NSE concentration was observed (P= 0·047). Serum NSE was also assayed at times 24, 48, 72 and 96 h post ictus. At 72 h a significant correlation existed between serum NSE levels and infarct volume (P= 0·012), and levels appeared to be approaching statistical significance at 48 h (P=0·067). No correlation existed at 24 and 96 h. In addition serum concentrations of NSE were compared to clinical outcome as determined by the Glasgow Outcome Score. Using the Mann-Whitney U test, there was no significant difference in maximum NSE level between patients graded 1–3 on the Glasgow Outcome Score and those graded 4 and 5. However, further studies are required on a larger population to more completely assess this. NSE may prove to be a useful marker of neuronal damage in the study of stroke, with particular application in the assessment of treatment.
    LanguageEnglish
    Pages39-39
    JournalRegulatory Peptides
    Volume30
    Issue number1
    DOIs
    Publication statusPublished - 21 Aug 1990

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    Phosphopyruvate Hydratase
    Cerebral Infarction
    Serum
    Nonparametric Statistics
    Radioimmunoassay
    Stroke
    Population

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    Winder, RJ., Cunningham, RT., Young, IS., O'Kane, OJ., McKinstry, CS., Johnston, CJ., ... Buchanan, SD. (1990). Serum neurone specific enolase levels in patients with cerebral infarction. Regulatory Peptides, 30(1), 39-39. https://doi.org/10.1016/0167-0115(90)90142-J
    Winder, RJ ; Cunningham, RT ; Young, IS ; O'Kane, OJ ; McKinstry, CS ; Johnston, CJ ; Dolan, O ; Hawkins, SA ; Buchanan, SD. / Serum neurone specific enolase levels in patients with cerebral infarction. In: Regulatory Peptides. 1990 ; Vol. 30, No. 1. pp. 39-39.
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    Winder, RJ, Cunningham, RT, Young, IS, O'Kane, OJ, McKinstry, CS, Johnston, CJ, Dolan, O, Hawkins, SA & Buchanan, SD 1990, 'Serum neurone specific enolase levels in patients with cerebral infarction', Regulatory Peptides, vol. 30, no. 1, pp. 39-39. https://doi.org/10.1016/0167-0115(90)90142-J

    Serum neurone specific enolase levels in patients with cerebral infarction. / Winder, RJ; Cunningham, RT; Young, IS; O'Kane, OJ; McKinstry, CS; Johnston, CJ; Dolan, O; Hawkins, SA; Buchanan, SD.

    In: Regulatory Peptides, Vol. 30, No. 1, 21.08.1990, p. 39-39.

    Research output: Contribution to journalArticle

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    AU - Johnston, CJ

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    AB - A radioimmunoassay has been developed and used to measure serum neurone specific enolase (NSE) concentrations in 24 patients, following cerebral infarction. A significant correlation between cerebral infarct volume and maximum serum NSE concentration was observed (P= 0·047). Serum NSE was also assayed at times 24, 48, 72 and 96 h post ictus. At 72 h a significant correlation existed between serum NSE levels and infarct volume (P= 0·012), and levels appeared to be approaching statistical significance at 48 h (P=0·067). No correlation existed at 24 and 96 h. In addition serum concentrations of NSE were compared to clinical outcome as determined by the Glasgow Outcome Score. Using the Mann-Whitney U test, there was no significant difference in maximum NSE level between patients graded 1–3 on the Glasgow Outcome Score and those graded 4 and 5. However, further studies are required on a larger population to more completely assess this. NSE may prove to be a useful marker of neuronal damage in the study of stroke, with particular application in the assessment of treatment.

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    Winder RJ, Cunningham RT, Young IS, O'Kane OJ, McKinstry CS, Johnston CJ et al. Serum neurone specific enolase levels in patients with cerebral infarction. Regulatory Peptides. 1990 Aug 21;30(1):39-39. https://doi.org/10.1016/0167-0115(90)90142-J