Serum neurone-specific enolase as an indicator of stroke volume

RT Cunningham, M Watt, John Winder, S McKinstry, JT Lawson, CF Johnston, SA Hawkins, KD Buchanan

    Research output: Contribution to journalArticle

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    Abstract

    Serum neurone-specific enolase (NSE) and computerized tomography (CT) stroke volume were compared in patients admitted within 24 h of an acute stroke. Serum samples were obtained on admission and daily for the next 4 days. Of 163 patients, CT scans revealed 25 with intracerebral haemorrhages, one haemorrhagic infarct and 83 measurable acute infarcts. The serum NSE levels of those with infarcts was significantly higher than in those with haemorrhages at 48 (P = 0 . 0003) and 72 h (P = 0 . 04). The maximum serum NSE value tended to occur later in those with large infarcts (P = 0 . 0035). There was a significant correlation between infarct volume and serum NSE at 48 h (r = 0 . 27, P = 0 . 015) and 96 h (r = 0 . 27, P = 0 . 015) and with the maximum serum NSE over the 4 days (r = 0 . 36, P = 0 . 001). There was no significant correlation between haemorrhage volume and NSE. In conclusion, serum NSE may be a useful marker of infarct volume in studies of therapy in acute stroke, Sampling for NSE should continue, at least in those with large infarcts, for longer than 4 days. Serum NSE cannot be used to distinguish between haemorrhage and infarction in patients with an acute stroke.
    LanguageEnglish
    Pages298-303
    JournalEuropean Journal of Clinical Investigation
    Volume26
    Issue number4
    Publication statusPublished - Apr 1996

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    Phosphopyruvate Hydratase
    Stroke Volume
    Serum
    Stroke
    Hemorrhage
    Tomography
    Cerebral Hemorrhage
    Infarction

    Keywords

    • cerebral infarction
    • intracerebral haemorrhage
    • neuronal damage
    • tomography
    • X-ray computed

    Cite this

    Cunningham, RT., Watt, M., Winder, J., McKinstry, S., Lawson, JT., Johnston, CF., ... Buchanan, KD. (1996). Serum neurone-specific enolase as an indicator of stroke volume. European Journal of Clinical Investigation, 26(4), 298-303.
    Cunningham, RT ; Watt, M ; Winder, John ; McKinstry, S ; Lawson, JT ; Johnston, CF ; Hawkins, SA ; Buchanan, KD. / Serum neurone-specific enolase as an indicator of stroke volume. In: European Journal of Clinical Investigation. 1996 ; Vol. 26, No. 4. pp. 298-303.
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    abstract = "Serum neurone-specific enolase (NSE) and computerized tomography (CT) stroke volume were compared in patients admitted within 24 h of an acute stroke. Serum samples were obtained on admission and daily for the next 4 days. Of 163 patients, CT scans revealed 25 with intracerebral haemorrhages, one haemorrhagic infarct and 83 measurable acute infarcts. The serum NSE levels of those with infarcts was significantly higher than in those with haemorrhages at 48 (P = 0 . 0003) and 72 h (P = 0 . 04). The maximum serum NSE value tended to occur later in those with large infarcts (P = 0 . 0035). There was a significant correlation between infarct volume and serum NSE at 48 h (r = 0 . 27, P = 0 . 015) and 96 h (r = 0 . 27, P = 0 . 015) and with the maximum serum NSE over the 4 days (r = 0 . 36, P = 0 . 001). There was no significant correlation between haemorrhage volume and NSE. In conclusion, serum NSE may be a useful marker of infarct volume in studies of therapy in acute stroke, Sampling for NSE should continue, at least in those with large infarcts, for longer than 4 days. Serum NSE cannot be used to distinguish between haemorrhage and infarction in patients with an acute stroke.",
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    Cunningham, RT, Watt, M, Winder, J, McKinstry, S, Lawson, JT, Johnston, CF, Hawkins, SA & Buchanan, KD 1996, 'Serum neurone-specific enolase as an indicator of stroke volume', European Journal of Clinical Investigation, vol. 26, no. 4, pp. 298-303.

    Serum neurone-specific enolase as an indicator of stroke volume. / Cunningham, RT; Watt, M; Winder, John; McKinstry, S; Lawson, JT; Johnston, CF; Hawkins, SA; Buchanan, KD.

    In: European Journal of Clinical Investigation, Vol. 26, No. 4, 04.1996, p. 298-303.

    Research output: Contribution to journalArticle

    TY - JOUR

    T1 - Serum neurone-specific enolase as an indicator of stroke volume

    AU - Cunningham, RT

    AU - Watt, M

    AU - Winder, John

    AU - McKinstry, S

    AU - Lawson, JT

    AU - Johnston, CF

    AU - Hawkins, SA

    AU - Buchanan, KD

    PY - 1996/4

    Y1 - 1996/4

    N2 - Serum neurone-specific enolase (NSE) and computerized tomography (CT) stroke volume were compared in patients admitted within 24 h of an acute stroke. Serum samples were obtained on admission and daily for the next 4 days. Of 163 patients, CT scans revealed 25 with intracerebral haemorrhages, one haemorrhagic infarct and 83 measurable acute infarcts. The serum NSE levels of those with infarcts was significantly higher than in those with haemorrhages at 48 (P = 0 . 0003) and 72 h (P = 0 . 04). The maximum serum NSE value tended to occur later in those with large infarcts (P = 0 . 0035). There was a significant correlation between infarct volume and serum NSE at 48 h (r = 0 . 27, P = 0 . 015) and 96 h (r = 0 . 27, P = 0 . 015) and with the maximum serum NSE over the 4 days (r = 0 . 36, P = 0 . 001). There was no significant correlation between haemorrhage volume and NSE. In conclusion, serum NSE may be a useful marker of infarct volume in studies of therapy in acute stroke, Sampling for NSE should continue, at least in those with large infarcts, for longer than 4 days. Serum NSE cannot be used to distinguish between haemorrhage and infarction in patients with an acute stroke.

    AB - Serum neurone-specific enolase (NSE) and computerized tomography (CT) stroke volume were compared in patients admitted within 24 h of an acute stroke. Serum samples were obtained on admission and daily for the next 4 days. Of 163 patients, CT scans revealed 25 with intracerebral haemorrhages, one haemorrhagic infarct and 83 measurable acute infarcts. The serum NSE levels of those with infarcts was significantly higher than in those with haemorrhages at 48 (P = 0 . 0003) and 72 h (P = 0 . 04). The maximum serum NSE value tended to occur later in those with large infarcts (P = 0 . 0035). There was a significant correlation between infarct volume and serum NSE at 48 h (r = 0 . 27, P = 0 . 015) and 96 h (r = 0 . 27, P = 0 . 015) and with the maximum serum NSE over the 4 days (r = 0 . 36, P = 0 . 001). There was no significant correlation between haemorrhage volume and NSE. In conclusion, serum NSE may be a useful marker of infarct volume in studies of therapy in acute stroke, Sampling for NSE should continue, at least in those with large infarcts, for longer than 4 days. Serum NSE cannot be used to distinguish between haemorrhage and infarction in patients with an acute stroke.

    KW - cerebral infarction

    KW - intracerebral haemorrhage

    KW - neuronal damage

    KW - tomography

    KW - X-ray computed

    M3 - Article

    VL - 26

    SP - 298

    EP - 303

    JO - European Journal of Clinical Investigation

    T2 - European Journal of Clinical Investigation

    JF - European Journal of Clinical Investigation

    SN - 0014-2972

    IS - 4

    ER -

    Cunningham RT, Watt M, Winder J, McKinstry S, Lawson JT, Johnston CF et al. Serum neurone-specific enolase as an indicator of stroke volume. European Journal of Clinical Investigation. 1996 Apr;26(4):298-303.