[Ser7]neurotensin: isolation from guinea pig intestine

Christopher Shaw, Lars Thim, J. Michael Conlon

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18 Citations (Scopus)


Using three antisera to neurotensin of defined regional specificity, a novel neurotensin has been identified in extracts of guinea pig brain and small intestine. The primary structure of the peptide was established as: pGlu Leu Tyr GIu Asn Lys Ser Arg Arg Pro Tyr He Leu. Guinea pig neurotensin differs from bovine neurotensin by substitution of a prolyl residue by a seryl residue at position 7. Synthetic [Ser7]neurotensin showed identical Chromatographie and immunochemical properties to guinea pig neurotensin. This difference in primary structure may account for some of the anomalous pharmacological effects of bovine neurotensin on guinea pig tissues.

Original languageEnglish
Pages (from-to)187-192
Number of pages6
JournalFEBS Letters
Issue number2
Publication statusPublished (in print/issue) - 7 Jul 1986


  • (Guinea pig)
  • Gastrointestinal peptide
  • HPLC
  • Neurotensin
  • Primary structure
  • Radioimmunoassay


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