Sequential changes in propionate metabolism during the development of cobalt/vitamin B12 deficiency in sheep

D. Glenn Kennedy, Finbarr P.M. O'Harte, W. John Blanchflower, Desmond A. Rice

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10 Citations (Scopus)


The changes in propionate metabolism that accompany cobalt deficiency in sheep are described. Two groups of sheep, fed either a cobalt sufficient or deficient diet, were given an iv propionate load at intervals during a 14 w experiment. There was a tendency towards increased propionate half-life as the animals became cobalt deficient. However, significant changes in the area under the plasma methylmalonic acid-time curve occurred very early, indicating significant impairment of propionate metabolism. Despite this, the area under the plasma glucose-time curve was unaffected by cobalt deficiency, suggesting that the impairment of propionate metabolism, although significant, is not extensive.

Original languageEnglish
Pages (from-to)233-241
Number of pages9
JournalBiological Trace Element Research
Issue number3
Publication statusPublished - Mar 1991


  • Cobalt
  • glucose
  • methylmalonic acid
  • propionate
  • sheep
  • vitamin B


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