Abstract
Three novel glass compositions, identified as NCL2 (SiO2-based), NCL4 (B2O3-based) and NCL7 (SiO2-based), along with apatite-wollastonite (AW) were processed to form sintered dense pellets, and subsequently evaluated for their in vitro bioactive potential, resulting physico-chemical properties and degradation rate. Microstructural analysis showed the carbonated hydroxyapatite (HCA) precipitate morphology following SBF testing to be composition-dependent. AW and the NCL7 formulation exhibited greater HCA precursor formation than the NCL2 and NCL4-derived pellets. Moreover, the NCL4 borate-based samples showed the highest biodegradation rate; with silicate-derived structures displaying the lowest weight loss after SBF immersion. The results of this study suggested that glass composition has significant influence on apatite-forming ability and also degradation rate, indicating the possibility to customise the properties of this class of materials towards the bone repair and regeneration process.
| Original language | English |
|---|---|
| Pages (from-to) | 12651-12657 |
| Number of pages | 7 |
| Journal | Ceramics International |
| Volume | 43 |
| Issue number | 15 |
| Early online date | 24 Jun 2017 |
| DOIs | |
| Publication status | Published (in print/issue) - 15 Oct 2017 |
Keywords
- Bioceramics
- Bioactivity
- Degradation
- Apatite formation
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