Sensitivity of novel silicate and borate-based glass structures on in vitro bioactivity and degradation behaviour

Elena Mancuso, O. Bretcanu, M. Marshall, K.W. Dalgarno

Research output: Contribution to journalArticle

5 Citations (Scopus)
11 Downloads (Pure)

Abstract

Three novel glass compositions, identified as NCL2 (SiO2-based), NCL4 (B2O3-based) and NCL7 (SiO2-based), along with apatite-wollastonite (AW) were processed to form sintered dense pellets, and subsequently evaluated for their in vitro bioactive potential, resulting physico-chemical properties and degradation rate. Microstructural analysis showed the carbonated hydroxyapatite (HCA) precipitate morphology following SBF testing to be composition-dependent. AW and the NCL7 formulation exhibited greater HCA precursor formation than the NCL2 and NCL4-derived pellets. Moreover, the NCL4 borate-based samples showed the highest biodegradation rate; with silicate-derived structures displaying the lowest weight loss after SBF immersion. The results of this study suggested that glass composition has significant influence on apatite-forming ability and also degradation rate, indicating the possibility to customise the properties of this class of materials towards the bone repair and regeneration process.
Original languageEnglish
Pages (from-to)12651-12657
Number of pages7
JournalCeramics International
Volume43
Issue number15
Early online date24 Jun 2017
DOIs
Publication statusPublished - 15 Oct 2017

Keywords

  • Bioceramics
  • Bioactivity
  • Degradation
  • Apatite formation

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