Sensitivity of novel silicate and borate-based glass structures on in vitro bioactivity and degradation behaviour

Elena Mancuso, O. Bretcanu, M. Marshall, K.W. Dalgarno

Research output: Contribution to journalArticle

5 Citations (Scopus)

Abstract

Three novel glass compositions, identified as NCL2 (SiO2-based), NCL4 (B2O3-based) and NCL7 (SiO2-based), along with apatite-wollastonite (AW) were processed to form sintered dense pellets, and subsequently evaluated for their in vitro bioactive potential, resulting physico-chemical properties and degradation rate. Microstructural analysis showed the carbonated hydroxyapatite (HCA) precipitate morphology following SBF testing to be composition-dependent. AW and the NCL7 formulation exhibited greater HCA precursor formation than the NCL2 and NCL4-derived pellets. Moreover, the NCL4 borate-based samples showed the highest biodegradation rate; with silicate-derived structures displaying the lowest weight loss after SBF immersion. The results of this study suggested that glass composition has significant influence on apatite-forming ability and also degradation rate, indicating the possibility to customise the properties of this class of materials towards the bone repair and regeneration process.
LanguageEnglish
Pages12651-12657
Number of pages7
JournalCeramics International
Volume43
Issue number15
Early online date24 Jun 2017
DOIs
Publication statusPublished - 15 Oct 2017

Fingerprint

Silicates
Apatites
Borates
Glass
Bone Regeneration
Immersion
Durapatite
Weight Loss
In Vitro Techniques
calcium silicate

Keywords

  • Bioceramics
  • Bioactivity
  • Degradation
  • Apatite formation

Cite this

@article{05ea634fc8b14399ac58efd2e2c86e91,
title = "Sensitivity of novel silicate and borate-based glass structures on in vitro bioactivity and degradation behaviour",
abstract = "Three novel glass compositions, identified as NCL2 (SiO2-based), NCL4 (B2O3-based) and NCL7 (SiO2-based), along with apatite-wollastonite (AW) were processed to form sintered dense pellets, and subsequently evaluated for their in vitro bioactive potential, resulting physico-chemical properties and degradation rate. Microstructural analysis showed the carbonated hydroxyapatite (HCA) precipitate morphology following SBF testing to be composition-dependent. AW and the NCL7 formulation exhibited greater HCA precursor formation than the NCL2 and NCL4-derived pellets. Moreover, the NCL4 borate-based samples showed the highest biodegradation rate; with silicate-derived structures displaying the lowest weight loss after SBF immersion. The results of this study suggested that glass composition has significant influence on apatite-forming ability and also degradation rate, indicating the possibility to customise the properties of this class of materials towards the bone repair and regeneration process.",
keywords = "Bioceramics, Bioactivity, Degradation, Apatite formation",
author = "Elena Mancuso and O. Bretcanu and M. Marshall and K.W. Dalgarno",
note = "cited By 4",
year = "2017",
month = "10",
day = "15",
doi = "10.1016/j.ceramint.2017.06.146",
language = "English",
volume = "43",
pages = "12651--12657",
journal = "Ceramics International",
issn = "0272-8842",
publisher = "Elsevier",
number = "15",

}

Sensitivity of novel silicate and borate-based glass structures on in vitro bioactivity and degradation behaviour. / Mancuso, Elena; Bretcanu, O.; Marshall, M.; Dalgarno, K.W.

In: Ceramics International, Vol. 43, No. 15, 15.10.2017, p. 12651-12657.

Research output: Contribution to journalArticle

TY - JOUR

T1 - Sensitivity of novel silicate and borate-based glass structures on in vitro bioactivity and degradation behaviour

AU - Mancuso, Elena

AU - Bretcanu, O.

AU - Marshall, M.

AU - Dalgarno, K.W.

N1 - cited By 4

PY - 2017/10/15

Y1 - 2017/10/15

N2 - Three novel glass compositions, identified as NCL2 (SiO2-based), NCL4 (B2O3-based) and NCL7 (SiO2-based), along with apatite-wollastonite (AW) were processed to form sintered dense pellets, and subsequently evaluated for their in vitro bioactive potential, resulting physico-chemical properties and degradation rate. Microstructural analysis showed the carbonated hydroxyapatite (HCA) precipitate morphology following SBF testing to be composition-dependent. AW and the NCL7 formulation exhibited greater HCA precursor formation than the NCL2 and NCL4-derived pellets. Moreover, the NCL4 borate-based samples showed the highest biodegradation rate; with silicate-derived structures displaying the lowest weight loss after SBF immersion. The results of this study suggested that glass composition has significant influence on apatite-forming ability and also degradation rate, indicating the possibility to customise the properties of this class of materials towards the bone repair and regeneration process.

AB - Three novel glass compositions, identified as NCL2 (SiO2-based), NCL4 (B2O3-based) and NCL7 (SiO2-based), along with apatite-wollastonite (AW) were processed to form sintered dense pellets, and subsequently evaluated for their in vitro bioactive potential, resulting physico-chemical properties and degradation rate. Microstructural analysis showed the carbonated hydroxyapatite (HCA) precipitate morphology following SBF testing to be composition-dependent. AW and the NCL7 formulation exhibited greater HCA precursor formation than the NCL2 and NCL4-derived pellets. Moreover, the NCL4 borate-based samples showed the highest biodegradation rate; with silicate-derived structures displaying the lowest weight loss after SBF immersion. The results of this study suggested that glass composition has significant influence on apatite-forming ability and also degradation rate, indicating the possibility to customise the properties of this class of materials towards the bone repair and regeneration process.

KW - Bioceramics

KW - Bioactivity

KW - Degradation

KW - Apatite formation

U2 - 10.1016/j.ceramint.2017.06.146

DO - 10.1016/j.ceramint.2017.06.146

M3 - Article

VL - 43

SP - 12651

EP - 12657

JO - Ceramics International

T2 - Ceramics International

JF - Ceramics International

SN - 0272-8842

IS - 15

ER -