TY - JOUR
T1 - Sensitivity of novel silicate and borate-based glass structures on in vitro bioactivity and degradation behaviour
AU - Mancuso, Elena
AU - Bretcanu, O.
AU - Marshall, M.
AU - Dalgarno, K.W.
PY - 2017/10/15
Y1 - 2017/10/15
N2 - Three novel glass compositions, identified as NCL2 (SiO2-based), NCL4 (B2O3-based) and NCL7 (SiO2-based), along with apatite-wollastonite (AW) were processed to form sintered dense pellets, and subsequently evaluated for their in vitro bioactive potential, resulting physico-chemical properties and degradation rate. Microstructural analysis showed the carbonated hydroxyapatite (HCA) precipitate morphology following SBF testing to be composition-dependent. AW and the NCL7 formulation exhibited greater HCA precursor formation than the NCL2 and NCL4-derived pellets. Moreover, the NCL4 borate-based samples showed the highest biodegradation rate; with silicate-derived structures displaying the lowest weight loss after SBF immersion. The results of this study suggested that glass composition has significant influence on apatite-forming ability and also degradation rate, indicating the possibility to customise the properties of this class of materials towards the bone repair and regeneration process.
AB - Three novel glass compositions, identified as NCL2 (SiO2-based), NCL4 (B2O3-based) and NCL7 (SiO2-based), along with apatite-wollastonite (AW) were processed to form sintered dense pellets, and subsequently evaluated for their in vitro bioactive potential, resulting physico-chemical properties and degradation rate. Microstructural analysis showed the carbonated hydroxyapatite (HCA) precipitate morphology following SBF testing to be composition-dependent. AW and the NCL7 formulation exhibited greater HCA precursor formation than the NCL2 and NCL4-derived pellets. Moreover, the NCL4 borate-based samples showed the highest biodegradation rate; with silicate-derived structures displaying the lowest weight loss after SBF immersion. The results of this study suggested that glass composition has significant influence on apatite-forming ability and also degradation rate, indicating the possibility to customise the properties of this class of materials towards the bone repair and regeneration process.
KW - Bioceramics
KW - Bioactivity
KW - Degradation
KW - Apatite formation
UR - https://pure.ulster.ac.uk/en/publications/sensitivity-of-novel-silicate-and-borate-based-glass-structures-o
U2 - 10.1016/j.ceramint.2017.06.146
DO - 10.1016/j.ceramint.2017.06.146
M3 - Article
C2 - 29042712
SN - 1873-3956
VL - 43
SP - 12651
EP - 12657
JO - Ceramics International
JF - Ceramics International
IS - 15
ER -