Semiconductor technology in protein kinase research and drug discovery: sensing a revolution

Nikhil Bhalla, Mirella Di Lorenzo, Pedro Estrela, Giordano Pula

Research output: Contribution to journalShort survey

3 Citations (Scopus)

Abstract

Since the discovery of protein kinase activity in 1954, close to 600 kinases have been discovered that have crucial roles in cell physiology. In several pathological conditions, aberrant protein kinase activity leads to abnormal cell and tissue physiology. Therefore, protein kinase inhibitors are investigated as potential treatments for several diseases, including dementia, diabetes, cancer and autoimmune and cardiovascular disease. Modern semiconductor technology has recently been applied to accelerate the discovery of novel protein kinase inhibitors that could become the standard-of-care drugs of tomorrow. Here, we describe current techniques and novel applications of semiconductor technologies in protein kinase inhibitor drug discovery.

Original languageEnglish
Pages (from-to)204-209
Number of pages6
JournalDrug Discovery Today
Volume22
Issue number2
Early online date22 Oct 2016
DOIs
Publication statusPublished - 1 Feb 2017

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