TY - JOUR
T1 - Self-nanoemulsifying drug delivery system (SNEDDS) mediated improved oral bioavailability of thymoquinone: optimization, characterization, pharmacokinetic, and hepatotoxicity studies
AU - Rathore, Charul
AU - Hemrajani, Chetna
AU - Sharma, Abhishek Kumar
AU - Gupta, Piyush Kumar
AU - Jha, Niraj Kumar
AU - Aljabali, Alaa A A
AU - Gupta, Gaurav
AU - Singh, Sachin Kumar
AU - Yang, Jen-Chang
AU - Dwivedi, Ram Prakash
AU - Dua, Kamal
AU - Chellappan, Dinesh Kumar
AU - Negi, Poonam
AU - Tambuwala, Murtaza M
PY - 2022/7/13
Y1 - 2022/7/13
N2 - Thymoquinone (TQ) is an antioxidant, anti-inflammatory, and hepatoprotective compound obtained from the black seed oil of Nigella sativa. However, high hydrophobicity, instability at higher pH levels, photosensitivity, and low oral bioavailability hinder its delivery to the target tissues. A self-nanoemulsifying drug delivery system (SNEDDS) was fabricated using the microemulsification technique to address these issues. Its physicochemical properties, thermodynamic stability studies, drug release kinetics, in vivo pharmacokinetics, and hepatoprotective activity were evaluated. The droplet size was in the nano-range (
AB - Thymoquinone (TQ) is an antioxidant, anti-inflammatory, and hepatoprotective compound obtained from the black seed oil of Nigella sativa. However, high hydrophobicity, instability at higher pH levels, photosensitivity, and low oral bioavailability hinder its delivery to the target tissues. A self-nanoemulsifying drug delivery system (SNEDDS) was fabricated using the microemulsification technique to address these issues. Its physicochemical properties, thermodynamic stability studies, drug release kinetics, in vivo pharmacokinetics, and hepatoprotective activity were evaluated. The droplet size was in the nano-range (
KW - Hepato-toxicity
KW - Thermodynamic stability
KW - Bioavailability
KW - SNEDDS
KW - In vitro release kinetics
U2 - 10.1007/s13346-022-01193-8
DO - 10.1007/s13346-022-01193-8
M3 - Article
C2 - 35831776
JO - Drug Delivery and Translational Research
JF - Drug Delivery and Translational Research
SN - 2190-393X
ER -