Self-nanoemulsifying drug delivery system (SNEDDS) mediated improved oral bioavailability of thymoquinone: optimization, characterization, pharmacokinetic, and hepatotoxicity studies

Charul Rathore, Chetna Hemrajani, Abhishek Kumar Sharma, Piyush Kumar Gupta, Niraj Kumar Jha, Alaa A A Aljabali, Gaurav Gupta, Sachin Kumar Singh, Jen-Chang Yang, Ram Prakash Dwivedi, Kamal Dua, Dinesh Kumar Chellappan, Poonam Negi, Murtaza M Tambuwala

Research output: Contribution to journalArticlepeer-review

Abstract

Thymoquinone (TQ) is an antioxidant, anti-inflammatory, and hepatoprotective compound obtained from the black seed oil of Nigella sativa. However, high hydrophobicity, instability at higher pH levels, photosensitivity, and low oral bioavailability hinder its delivery to the target tissues. A self-nanoemulsifying drug delivery system (SNEDDS) was fabricated using the microemulsification technique to address these issues. Its physicochemical properties, thermodynamic stability studies, drug release kinetics, in vivo pharmacokinetics, and hepatoprotective activity were evaluated. The droplet size was in the nano-range (
Original languageEnglish
JournalDrug Delivery and Translational Research
Early online date13 Jul 2022
DOIs
Publication statusE-pub ahead of print - 13 Jul 2022

Keywords

  • Hepato-toxicity
  • Thermodynamic stability
  • Bioavailability
  • SNEDDS
  • In vitro release kinetics

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