Self-nanoemulsifying drug delivery system (SNEDDS) mediated improved oral bioavailability of thymoquinone: optimization, characterization, pharmacokinetic, and hepatotoxicity studies

Charul Rathore; Chetna Hemrajani; Abhishek Kumar Sharma; Piyush Kumar Gupta; Niraj Kumar Jha; Alaa A A Aljabali; Gaurav Gupta; Sachin Kumar Singh; Jen-Chang Yang; Ram Prakash Dwivedi; Kamal Dua; Dinesh Kumar Chellappan; Poonam Negi; Murtaza M Tambuwala

doi:10.1007/s13346-022-01193-8

Self-nanoemulsifying drug delivery system (SNEDDS) mediated improved oral bioavailability of thymoquinone: optimization, characterization, pharmacokinetic, and hepatotoxicity studies

Charul Rathore, Chetna Hemrajani, Abhishek Kumar Sharma, Piyush Kumar Gupta, Niraj Kumar Jha, Alaa A A Aljabali, Gaurav Gupta, Sachin Kumar Singh, Jen-Chang Yang, Ram Prakash Dwivedi, Kamal Dua, Dinesh Kumar Chellappan, Poonam Negi, Murtaza M Tambuwala

Research output: Contribution to journal › Article › peer-review

4 Citations (Scopus)

6 Downloads (Pure)

Abstract

Thymoquinone (TQ) is an antioxidant, anti-inflammatory, and hepatoprotective compound obtained from the black seed oil of Nigella sativa. However, high hydrophobicity, instability at higher pH levels, photosensitivity, and low oral bioavailability hinder its delivery to the target tissues. A self-nanoemulsifying drug delivery system (SNEDDS) was fabricated using the microemulsification technique to address these issues. Its physicochemical properties, thermodynamic stability studies, drug release kinetics, in vivo pharmacokinetics, and hepatoprotective activity were evaluated. The droplet size was in the nano-range (

Original language	English
Pages (from-to)	292-307
Number of pages	16
Journal	Drug Delivery and Translational Research
Volume	13
Early online date	13 Jul 2022
DOIs	https://doi.org/10.1007/s13346-022-01193-8
Publication status	Published online - 13 Jul 2022

Bibliographical note

Funding Information:
M/s Gattefosse, Saint-Priest, France, provided gift samples of Labrafil M 2125 CS, Labrafac Lipophile WL 1349, Labrafac PG, and Compritol 888 ATO to the authors. The authors are grateful to Shoolini University for supporting them with their research.

Publisher Copyright:
© 2022, The Author(s).

Keywords

Hepato-toxicity
Thermodynamic stability
Bioavailability
SNEDDS
In vitro release kinetics

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

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10.1007/s13346-022-01193-8

Rathore2022_Article_Self-nanoemulsifyingDrugDeliveFinal published version, 2.38 MBLicence: CC BY

Cite this

Rathore, C., Hemrajani, C., Sharma, A. K., Gupta, P. K., Jha, N. K., Aljabali, A. A. A., Gupta, G., Singh, S. K., Yang, J-C., Dwivedi, R. P., Dua, K., Chellappan, D. K., Negi, P., & Tambuwala, M. M. (2022). Self-nanoemulsifying drug delivery system (SNEDDS) mediated improved oral bioavailability of thymoquinone: optimization, characterization, pharmacokinetic, and hepatotoxicity studies. Drug Delivery and Translational Research, 13, 292-307. https://doi.org/10.1007/s13346-022-01193-8

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title = "Self-nanoemulsifying drug delivery system (SNEDDS) mediated improved oral bioavailability of thymoquinone: optimization, characterization, pharmacokinetic, and hepatotoxicity studies",

abstract = "Thymoquinone (TQ) is an antioxidant, anti-inflammatory, and hepatoprotective compound obtained from the black seed oil of Nigella sativa. However, high hydrophobicity, instability at higher pH levels, photosensitivity, and low oral bioavailability hinder its delivery to the target tissues. A self-nanoemulsifying drug delivery system (SNEDDS) was fabricated using the microemulsification technique to address these issues. Its physicochemical properties, thermodynamic stability studies, drug release kinetics, in vivo pharmacokinetics, and hepatoprotective activity were evaluated. The droplet size was in the nano-range (",

keywords = "Hepato-toxicity, Thermodynamic stability, Bioavailability, SNEDDS, In vitro release kinetics",

author = "Charul Rathore and Chetna Hemrajani and Sharma, {Abhishek Kumar} and Gupta, {Piyush Kumar} and Jha, {Niraj Kumar} and Aljabali, {Alaa A A} and Gaurav Gupta and Singh, {Sachin Kumar} and Jen-Chang Yang and Dwivedi, {Ram Prakash} and Kamal Dua and Chellappan, {Dinesh Kumar} and Poonam Negi and Tambuwala, {Murtaza M}",

note = "Funding Information: M/s Gattefosse, Saint-Priest, France, provided gift samples of Labrafil M 2125 CS, Labrafac Lipophile WL 1349, Labrafac PG, and Compritol 888 ATO to the authors. The authors are grateful to Shoolini University for supporting them with their research. Publisher Copyright: {\textcopyright} 2022, The Author(s).",

year = "2022",

month = jul,

day = "13",

doi = "10.1007/s13346-022-01193-8",

language = "English",

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Rathore, C, Hemrajani, C, Sharma, AK, Gupta, PK, Jha, NK, Aljabali, AAA, Gupta, G, Singh, SK, Yang, J-C, Dwivedi, RP, Dua, K, Chellappan, DK, Negi, P & Tambuwala, MM 2022, 'Self-nanoemulsifying drug delivery system (SNEDDS) mediated improved oral bioavailability of thymoquinone: optimization, characterization, pharmacokinetic, and hepatotoxicity studies', Drug Delivery and Translational Research, vol. 13, pp. 292-307. https://doi.org/10.1007/s13346-022-01193-8

Self-nanoemulsifying drug delivery system (SNEDDS) mediated improved oral bioavailability of thymoquinone: optimization, characterization, pharmacokinetic, and hepatotoxicity studies. / Rathore, Charul; Hemrajani, Chetna; Sharma, Abhishek Kumar et al.
In: Drug Delivery and Translational Research, Vol. 13, 13.07.2022, p. 292-307.

Research output: Contribution to journal › Article › peer-review

TY - JOUR

T1 - Self-nanoemulsifying drug delivery system (SNEDDS) mediated improved oral bioavailability of thymoquinone: optimization, characterization, pharmacokinetic, and hepatotoxicity studies

AU - Rathore, Charul

AU - Hemrajani, Chetna

AU - Sharma, Abhishek Kumar

AU - Gupta, Piyush Kumar

AU - Jha, Niraj Kumar

AU - Aljabali, Alaa A A

AU - Gupta, Gaurav

AU - Singh, Sachin Kumar

AU - Yang, Jen-Chang

AU - Dwivedi, Ram Prakash

AU - Dua, Kamal

AU - Chellappan, Dinesh Kumar

AU - Negi, Poonam

AU - Tambuwala, Murtaza M

N1 - Funding Information: M/s Gattefosse, Saint-Priest, France, provided gift samples of Labrafil M 2125 CS, Labrafac Lipophile WL 1349, Labrafac PG, and Compritol 888 ATO to the authors. The authors are grateful to Shoolini University for supporting them with their research. Publisher Copyright: © 2022, The Author(s).

PY - 2022/7/13

Y1 - 2022/7/13

N2 - Thymoquinone (TQ) is an antioxidant, anti-inflammatory, and hepatoprotective compound obtained from the black seed oil of Nigella sativa. However, high hydrophobicity, instability at higher pH levels, photosensitivity, and low oral bioavailability hinder its delivery to the target tissues. A self-nanoemulsifying drug delivery system (SNEDDS) was fabricated using the microemulsification technique to address these issues. Its physicochemical properties, thermodynamic stability studies, drug release kinetics, in vivo pharmacokinetics, and hepatoprotective activity were evaluated. The droplet size was in the nano-range (

AB - Thymoquinone (TQ) is an antioxidant, anti-inflammatory, and hepatoprotective compound obtained from the black seed oil of Nigella sativa. However, high hydrophobicity, instability at higher pH levels, photosensitivity, and low oral bioavailability hinder its delivery to the target tissues. A self-nanoemulsifying drug delivery system (SNEDDS) was fabricated using the microemulsification technique to address these issues. Its physicochemical properties, thermodynamic stability studies, drug release kinetics, in vivo pharmacokinetics, and hepatoprotective activity were evaluated. The droplet size was in the nano-range (

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KW - Thermodynamic stability

KW - Bioavailability

KW - SNEDDS

KW - In vitro release kinetics

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DO - 10.1007/s13346-022-01193-8

M3 - Article

C2 - 35831776

SN - 2190-393X

VL - 13

SP - 292

EP - 307

JO - Drug Delivery and Translational Research

JF - Drug Delivery and Translational Research

ER -

Rathore C, Hemrajani C, Sharma AK, Gupta PK, Jha NK, Aljabali AAA et al. Self-nanoemulsifying drug delivery system (SNEDDS) mediated improved oral bioavailability of thymoquinone: optimization, characterization, pharmacokinetic, and hepatotoxicity studies. Drug Delivery and Translational Research. 2022 Jul 13;13:292-307. Epub 2022 Jul 13. doi: 10.1007/s13346-022-01193-8

Self-nanoemulsifying drug delivery system (SNEDDS) mediated improved oral bioavailability of thymoquinone: optimization, characterization, pharmacokinetic, and hepatotoxicity studies

Abstract

Bibliographical note

Keywords

UN SDGs

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