Thymoquinone (TQ) is an antioxidant, anti-inflammatory, and hepatoprotective compound obtained from the black seed oil of Nigella sativa. However, high hydrophobicity, instability at higher pH levels, photosensitivity, and low oral bioavailability hinder its delivery to the target tissues. A self-nanoemulsifying drug delivery system (SNEDDS) was fabricated using the microemulsification technique to address these issues. Its physicochemical properties, thermodynamic stability studies, drug release kinetics, in vivo pharmacokinetics, and hepatoprotective activity were evaluated. The droplet size was in the nano-range (
|Number of pages||16|
|Journal||Drug Delivery and Translational Research|
|Early online date||13 Jul 2022|
|Publication status||Published online - 13 Jul 2022|
Bibliographical noteFunding Information:
M/s Gattefosse, Saint-Priest, France, provided gift samples of Labrafil M 2125 CS, Labrafac Lipophile WL 1349, Labrafac PG, and Compritol 888 ATO to the authors. The authors are grateful to Shoolini University for supporting them with their research.
© 2022, The Author(s).
- Thermodynamic stability
- In vitro release kinetics