Self-nanoemulsifying drug delivery system (SNEDDS) mediated improved oral bioavailability of thymoquinone: optimization, characterization, pharmacokinetic, and hepatotoxicity studies

Charul Rathore; Chetna Hemrajani; Abhishek Kumar Sharma; Piyush Kumar Gupta; Niraj Kumar Jha; Alaa A A Aljabali; Gaurav Gupta; Sachin Kumar Singh; Jen-Chang Yang; Ram Prakash Dwivedi; Kamal Dua; Dinesh Kumar Chellappan; Poonam Negi; Murtaza M Tambuwala

doi:10.1007/s13346-022-01193-8

Self-nanoemulsifying drug delivery system (SNEDDS) mediated improved oral bioavailability of thymoquinone: optimization, characterization, pharmacokinetic, and hepatotoxicity studies

Charul Rathore, Chetna Hemrajani, Abhishek Kumar Sharma, Piyush Kumar Gupta, Niraj Kumar Jha, Alaa A A Aljabali, Gaurav Gupta, Sachin Kumar Singh, Jen-Chang Yang, Ram Prakash Dwivedi, Kamal Dua, Dinesh Kumar Chellappan, Poonam Negi, Murtaza M Tambuwala

Research output: Contribution to journal › Article › peer-review

Abstract

Thymoquinone (TQ) is an antioxidant, anti-inflammatory, and hepatoprotective compound obtained from the black seed oil of Nigella sativa. However, high hydrophobicity, instability at higher pH levels, photosensitivity, and low oral bioavailability hinder its delivery to the target tissues. A self-nanoemulsifying drug delivery system (SNEDDS) was fabricated using the microemulsification technique to address these issues. Its physicochemical properties, thermodynamic stability studies, drug release kinetics, in vivo pharmacokinetics, and hepatoprotective activity were evaluated. The droplet size was in the nano-range (

Original language	English
Journal	Drug Delivery and Translational Research
Early online date	13 Jul 2022
DOIs	https://doi.org/10.1007/s13346-022-01193-8
Publication status	E-pub ahead of print - 13 Jul 2022

Keywords

Hepato-toxicity
Thermodynamic stability
Bioavailability
SNEDDS
In vitro release kinetics

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

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10.1007/s13346-022-01193-8

Rathore2022_Article_Self-nanoemulsifyingDrugDeliveFinal published version, 2.38 MBLicence: CC BY

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Rathore, C., Hemrajani, C., Sharma, A. K., Gupta, P. K., Jha, N. K., Aljabali, A. A. A., Gupta, G., Singh, S. K., Yang, J-C., Dwivedi, R. P., Dua, K., Chellappan, D. K., Negi, P., & Tambuwala, M. M. (2022). Self-nanoemulsifying drug delivery system (SNEDDS) mediated improved oral bioavailability of thymoquinone: optimization, characterization, pharmacokinetic, and hepatotoxicity studies. Drug Delivery and Translational Research. https://doi.org/10.1007/s13346-022-01193-8

Rathore, Charul ; Hemrajani, Chetna ; Sharma, Abhishek Kumar ; Gupta, Piyush Kumar ; Jha, Niraj Kumar ; Aljabali, Alaa A A ; Gupta, Gaurav ; Singh, Sachin Kumar ; Yang, Jen-Chang ; Dwivedi, Ram Prakash ; Dua, Kamal ; Chellappan, Dinesh Kumar ; Negi, Poonam ; Tambuwala, Murtaza M. / Self-nanoemulsifying drug delivery system (SNEDDS) mediated improved oral bioavailability of thymoquinone: optimization, characterization, pharmacokinetic, and hepatotoxicity studies. In: Drug Delivery and Translational Research. 2022.

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title = "Self-nanoemulsifying drug delivery system (SNEDDS) mediated improved oral bioavailability of thymoquinone: optimization, characterization, pharmacokinetic, and hepatotoxicity studies",

abstract = "Thymoquinone (TQ) is an antioxidant, anti-inflammatory, and hepatoprotective compound obtained from the black seed oil of Nigella sativa. However, high hydrophobicity, instability at higher pH levels, photosensitivity, and low oral bioavailability hinder its delivery to the target tissues. A self-nanoemulsifying drug delivery system (SNEDDS) was fabricated using the microemulsification technique to address these issues. Its physicochemical properties, thermodynamic stability studies, drug release kinetics, in vivo pharmacokinetics, and hepatoprotective activity were evaluated. The droplet size was in the nano-range (",

keywords = "Hepato-toxicity, Thermodynamic stability, Bioavailability, SNEDDS, In vitro release kinetics",

author = "Charul Rathore and Chetna Hemrajani and Sharma, {Abhishek Kumar} and Gupta, {Piyush Kumar} and Jha, {Niraj Kumar} and Aljabali, {Alaa A A} and Gaurav Gupta and Singh, {Sachin Kumar} and Jen-Chang Yang and Dwivedi, {Ram Prakash} and Kamal Dua and Chellappan, {Dinesh Kumar} and Poonam Negi and Tambuwala, {Murtaza M}",

year = "2022",

month = jul,

day = "13",

doi = "10.1007/s13346-022-01193-8",

language = "English",

journal = "Drug Delivery and Translational Research",

issn = "2190-393X",

publisher = "Springer",

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Rathore, C, Hemrajani, C, Sharma, AK, Gupta, PK, Jha, NK, Aljabali, AAA, Gupta, G, Singh, SK, Yang, J-C, Dwivedi, RP, Dua, K, Chellappan, DK, Negi, P & Tambuwala, MM 2022, 'Self-nanoemulsifying drug delivery system (SNEDDS) mediated improved oral bioavailability of thymoquinone: optimization, characterization, pharmacokinetic, and hepatotoxicity studies', Drug Delivery and Translational Research. https://doi.org/10.1007/s13346-022-01193-8

Self-nanoemulsifying drug delivery system (SNEDDS) mediated improved oral bioavailability of thymoquinone: optimization, characterization, pharmacokinetic, and hepatotoxicity studies. / Rathore, Charul; Hemrajani, Chetna; Sharma, Abhishek Kumar; Gupta, Piyush Kumar; Jha, Niraj Kumar; Aljabali, Alaa A A; Gupta, Gaurav; Singh, Sachin Kumar; Yang, Jen-Chang; Dwivedi, Ram Prakash; Dua, Kamal; Chellappan, Dinesh Kumar; Negi, Poonam; Tambuwala, Murtaza M.

In: Drug Delivery and Translational Research, 13.07.2022.

Research output: Contribution to journal › Article › peer-review

TY - JOUR

T1 - Self-nanoemulsifying drug delivery system (SNEDDS) mediated improved oral bioavailability of thymoquinone: optimization, characterization, pharmacokinetic, and hepatotoxicity studies

AU - Rathore, Charul

AU - Hemrajani, Chetna

AU - Sharma, Abhishek Kumar

AU - Gupta, Piyush Kumar

AU - Jha, Niraj Kumar

AU - Aljabali, Alaa A A

AU - Gupta, Gaurav

AU - Singh, Sachin Kumar

AU - Yang, Jen-Chang

AU - Dwivedi, Ram Prakash

AU - Dua, Kamal

AU - Chellappan, Dinesh Kumar

AU - Negi, Poonam

AU - Tambuwala, Murtaza M

PY - 2022/7/13

Y1 - 2022/7/13

N2 - Thymoquinone (TQ) is an antioxidant, anti-inflammatory, and hepatoprotective compound obtained from the black seed oil of Nigella sativa. However, high hydrophobicity, instability at higher pH levels, photosensitivity, and low oral bioavailability hinder its delivery to the target tissues. A self-nanoemulsifying drug delivery system (SNEDDS) was fabricated using the microemulsification technique to address these issues. Its physicochemical properties, thermodynamic stability studies, drug release kinetics, in vivo pharmacokinetics, and hepatoprotective activity were evaluated. The droplet size was in the nano-range (

AB - Thymoquinone (TQ) is an antioxidant, anti-inflammatory, and hepatoprotective compound obtained from the black seed oil of Nigella sativa. However, high hydrophobicity, instability at higher pH levels, photosensitivity, and low oral bioavailability hinder its delivery to the target tissues. A self-nanoemulsifying drug delivery system (SNEDDS) was fabricated using the microemulsification technique to address these issues. Its physicochemical properties, thermodynamic stability studies, drug release kinetics, in vivo pharmacokinetics, and hepatoprotective activity were evaluated. The droplet size was in the nano-range (

KW - Hepato-toxicity

KW - Thermodynamic stability

KW - Bioavailability

KW - SNEDDS

KW - In vitro release kinetics

U2 - 10.1007/s13346-022-01193-8

DO - 10.1007/s13346-022-01193-8

M3 - Article

C2 - 35831776

JO - Drug Delivery and Translational Research

JF - Drug Delivery and Translational Research

SN - 2190-393X

ER -

Self-nanoemulsifying drug delivery system (SNEDDS) mediated improved oral bioavailability of thymoquinone: optimization, characterization, pharmacokinetic, and hepatotoxicity studies

Abstract

Keywords

UN SDGs

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