Self-nanoemulsifying drug delivery system (SNEDDS) mediated improved oral bioavailability of thymoquinone: optimization, characterization, pharmacokinetic, and hepatotoxicity studies

Charul Rathore, Chetna Hemrajani, Abhishek Kumar Sharma, Piyush Kumar Gupta, Niraj Kumar Jha, Alaa A A Aljabali, Gaurav Gupta, Sachin Kumar Singh, Jen-Chang Yang, Ram Prakash Dwivedi, Kamal Dua, Dinesh Kumar Chellappan, Poonam Negi, Murtaza M Tambuwala

Research output: Contribution to journalArticlepeer-review

21 Citations (Scopus)
23 Downloads (Pure)

Abstract

Thymoquinone (TQ) is an antioxidant, anti-inflammatory, and hepatoprotective compound obtained from the black seed oil of Nigella sativa. However, high hydrophobicity, instability at higher pH levels, photosensitivity, and low oral bioavailability hinder its delivery to the target tissues. A self-nanoemulsifying drug delivery system (SNEDDS) was fabricated using the microemulsification technique to address these issues. Its physicochemical properties, thermodynamic stability studies, drug release kinetics, in vivo pharmacokinetics, and hepatoprotective activity were evaluated. The droplet size was in the nano-range (
Original languageEnglish
Pages (from-to)292-307
Number of pages16
JournalDrug Delivery and Translational Research
Volume13
Early online date13 Jul 2022
DOIs
Publication statusPublished online - 13 Jul 2022

Bibliographical note

Funding Information:
M/s Gattefosse, Saint-Priest, France, provided gift samples of Labrafil M 2125 CS, Labrafac Lipophile WL 1349, Labrafac PG, and Compritol 888 ATO to the authors. The authors are grateful to Shoolini University for supporting them with their research.

Publisher Copyright:
© 2022, The Author(s).

Keywords

  • Hepato-toxicity
  • Thermodynamic stability
  • Bioavailability
  • SNEDDS
  • In vitro release kinetics

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