The two electron electro-oxidation of N,N-dimethylphenylene-1,4-diamine and related compounds in aqueous solution leads to the formation of the corresponding 1,4-diimine which reacts with a range of thiol compounds. The resulting ring substituted (R-S-) diamine is further oxidised leading to an increase in the oxidative current which is proportional to the concentration of the thiol species. The electrode responses were found to be selective towards species including cysteine and homocysteine containing sulfhydryl groups (RSH) with no reaction observed with either methionine (CH3SCH2CH(COOH)NH2) or cystine (cystein-S-S-cysteine). The potential required to oxidise the ring substituted diamine is found to be dependent upon the nature of the thiol constituent and may allow some scope for speciation studies.
| Language | English |
|---|
| Pages | 661-663 |
|---|
| Journal | ANALYST |
|---|
| Volume | 125 |
|---|
| Issue number | 4 |
|---|
| Publication status | Published - Apr 2000 |
|---|
Cite this
Lawrence, NS.
, Davis, J., Jiang, L., Jones, TGJ., Davis, SN., & Compton, RG. (2000).
Selective determination of thiols: a novel electroanalytical approach.
ANALYST,
125(4), 661-663.
@article{a2d6dd3e3e2344ae8c47a59dfb45ad0f,
title = "Selective determination of thiols: a novel electroanalytical approach",
abstract = "The two electron electro-oxidation of N,N-dimethylphenylene-1,4-diamine and related compounds in aqueous solution leads to the formation of the corresponding 1,4-diimine which reacts with a range of thiol compounds. The resulting ring substituted (R-S-) diamine is further oxidised leading to an increase in the oxidative current which is proportional to the concentration of the thiol species. The electrode responses were found to be selective towards species including cysteine and homocysteine containing sulfhydryl groups (RSH) with no reaction observed with either methionine (CH3SCH2CH(COOH)NH2) or cystine (cystein-S-S-cysteine). The potential required to oxidise the ring substituted diamine is found to be dependent upon the nature of the thiol constituent and may allow some scope for speciation studies.",
author = "NS Lawrence and J Davis and L Jiang and TGJ Jones and SN Davis and RG Compton",
year = "2000",
month = "4",
language = "English",
volume = "125",
pages = "661--663",
journal = "ANALYST",
issn = "0003-2654",
publisher = "Royal Society of Chemistry",
number = "4",
}
Lawrence, NS
, Davis, J, Jiang, L, Jones, TGJ, Davis, SN & Compton, RG 2000, '
Selective determination of thiols: a novel electroanalytical approach',
ANALYST, vol. 125, no. 4, pp. 661-663.
Selective determination of thiols: a novel electroanalytical approach. / Lawrence, NS; Davis, J; Jiang, L; Jones, TGJ; Davis, SN; Compton, RG.
In:
ANALYST, Vol. 125, No. 4, 04.2000, p. 661-663.
Research output: Contribution to journal › Article
TY - JOUR
T1 - Selective determination of thiols: a novel electroanalytical approach
AU - Lawrence, NS
AU - Davis, J
AU - Jiang, L
AU - Jones, TGJ
AU - Davis, SN
AU - Compton, RG
PY - 2000/4
Y1 - 2000/4
N2 - The two electron electro-oxidation of N,N-dimethylphenylene-1,4-diamine and related compounds in aqueous solution leads to the formation of the corresponding 1,4-diimine which reacts with a range of thiol compounds. The resulting ring substituted (R-S-) diamine is further oxidised leading to an increase in the oxidative current which is proportional to the concentration of the thiol species. The electrode responses were found to be selective towards species including cysteine and homocysteine containing sulfhydryl groups (RSH) with no reaction observed with either methionine (CH3SCH2CH(COOH)NH2) or cystine (cystein-S-S-cysteine). The potential required to oxidise the ring substituted diamine is found to be dependent upon the nature of the thiol constituent and may allow some scope for speciation studies.
AB - The two electron electro-oxidation of N,N-dimethylphenylene-1,4-diamine and related compounds in aqueous solution leads to the formation of the corresponding 1,4-diimine which reacts with a range of thiol compounds. The resulting ring substituted (R-S-) diamine is further oxidised leading to an increase in the oxidative current which is proportional to the concentration of the thiol species. The electrode responses were found to be selective towards species including cysteine and homocysteine containing sulfhydryl groups (RSH) with no reaction observed with either methionine (CH3SCH2CH(COOH)NH2) or cystine (cystein-S-S-cysteine). The potential required to oxidise the ring substituted diamine is found to be dependent upon the nature of the thiol constituent and may allow some scope for speciation studies.
M3 - Article
VL - 125
SP - 661
EP - 663
JO - ANALYST
T2 - ANALYST
JF - ANALYST
SN - 0003-2654
IS - 4
ER -