Selective determination of thiols: a novel electroanalytical approach

NS Lawrence, J Davis, L Jiang, TGJ Jones, SN Davis, RG Compton

    Research output: Contribution to journalArticle

    52 Citations (Scopus)

    Abstract

    The two electron electro-oxidation of N,N-dimethylphenylene-1,4-diamine and related compounds in aqueous solution leads to the formation of the corresponding 1,4-diimine which reacts with a range of thiol compounds. The resulting ring substituted (R-S-) diamine is further oxidised leading to an increase in the oxidative current which is proportional to the concentration of the thiol species. The electrode responses were found to be selective towards species including cysteine and homocysteine containing sulfhydryl groups (RSH) with no reaction observed with either methionine (CH3SCH2CH(COOH)NH2) or cystine (cystein-S-S-cysteine). The potential required to oxidise the ring substituted diamine is found to be dependent upon the nature of the thiol constituent and may allow some scope for speciation studies.
    LanguageEnglish
    Pages661-663
    JournalANALYST
    Volume125
    Issue number4
    Publication statusPublished - Apr 2000

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    Diamines
    Sulfhydryl Compounds
    Cysteine
    Electrooxidation
    Homocysteine
    Methionine
    Electrodes
    Electrons

    Cite this

    Lawrence, NS., Davis, J., Jiang, L., Jones, TGJ., Davis, SN., & Compton, RG. (2000). Selective determination of thiols: a novel electroanalytical approach. ANALYST, 125(4), 661-663.
    Lawrence, NS ; Davis, J ; Jiang, L ; Jones, TGJ ; Davis, SN ; Compton, RG. / Selective determination of thiols: a novel electroanalytical approach. In: ANALYST. 2000 ; Vol. 125, No. 4. pp. 661-663.
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    Lawrence, NS, Davis, J, Jiang, L, Jones, TGJ, Davis, SN & Compton, RG 2000, 'Selective determination of thiols: a novel electroanalytical approach', ANALYST, vol. 125, no. 4, pp. 661-663.

    Selective determination of thiols: a novel electroanalytical approach. / Lawrence, NS; Davis, J; Jiang, L; Jones, TGJ; Davis, SN; Compton, RG.

    In: ANALYST, Vol. 125, No. 4, 04.2000, p. 661-663.

    Research output: Contribution to journalArticle

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    AB - The two electron electro-oxidation of N,N-dimethylphenylene-1,4-diamine and related compounds in aqueous solution leads to the formation of the corresponding 1,4-diimine which reacts with a range of thiol compounds. The resulting ring substituted (R-S-) diamine is further oxidised leading to an increase in the oxidative current which is proportional to the concentration of the thiol species. The electrode responses were found to be selective towards species including cysteine and homocysteine containing sulfhydryl groups (RSH) with no reaction observed with either methionine (CH3SCH2CH(COOH)NH2) or cystine (cystein-S-S-cysteine). The potential required to oxidise the ring substituted diamine is found to be dependent upon the nature of the thiol constituent and may allow some scope for speciation studies.

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    Lawrence NS, Davis J, Jiang L, Jones TGJ, Davis SN, Compton RG. Selective determination of thiols: a novel electroanalytical approach. ANALYST. 2000 Apr;125(4):661-663.