Secondary hyperparathyroidism: Predictors and relationship with vitamin D status, bone turnover markers and bone mineral density

Donal Fitzpatrick; Eamon Laird; Mary Ward; Leane Hoey; Catherine F Hughes; J J Strain; Conal Cunningham; Martin Healy; Anne M Molloy; Helene McNulty; Rosaleen Lannon; Kevin McCarroll

doi:10.1016/j.bone.2024.117108

Secondary hyperparathyroidism: Predictors and relationship with vitamin D status, bone turnover markers and bone mineral density

Donal Fitzpatrick
, Eamon Laird
, Mary Ward
, Leane Hoey
, Catherine F Hughes
, J J Strain
, Conal Cunningham
, Martin Healy
, Anne M Molloy
, Helene McNulty
, Rosaleen Lannon
, Kevin McCarroll

Trinity College Dublin

Research output: Contribution to journal › Article › peer-review

11 Citations (Scopus)

211 Downloads (Pure)

Abstract

Secondary hyperparathyroidism (SHPT) has adverse implications for bone health but is relatively understudied. In this study we examine the prevalence and determinants of SHPT and describe the relationship of SHPT with bone turnover markers and bone mineral density (BMD) in older Irish adults. Eligible participants (n = 4139) were identified from the Trinity-Ulster-Department of Agriculture (TUDA) study, a cohort of Irish adults aged ≥60 years. Exclusion criteria included an estimated glomerular filtration rate (eGFR) 2.5 mmol/l to remove hyperparathyroidism due to advanced chronic kidney disease (CKD) and primary hyperparathyroidism respectively. The relationship between SHPT and bone turnover markers and BMD (measured by densitometry) was examined in a subsample (n = 1488). Vitamin D deficiency was defined as 25-hydroxyvitamin D [25 (OH)D]

Original language	English
Article number	117108
Pages (from-to)	1-10
Number of pages	10
Journal	Bone
Volume	184
Early online date	18 Apr 2024
DOIs	https://doi.org/10.1016/j.bone.2024.117108
Publication status	Published (in print/issue) - 1 Jul 2024

Bibliographical note

Publisher Copyright:
© 2024

Funding

The authors acknowledge funding from the Mercer's Institute for Research on Ageing, the Irish Department of Agriculture, Food and the Marine and the Health Research Board (under its Food Institutional Research Measure) and the Northern Ireland Department for Employment and Learning (under its strengthening the all-Ireland research base initiative).

Funders
Department of Agriculture, Food and the Marine, Ireland
Department for Employment and Learning, Northern Ireland

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

SDG 3 Good Health and Well-being

Keywords

Calcium supplementation
Markers
Secondary hyperparathyroidism
Vitamin D
Parathyroid hormone
Bone turnover
Bone mineral density

Access to Document

10.1016/j.bone.2024.117108

1-s2.0-S8756328224000978-mainFinal published version, 883 KBLicence: CC BY

Cite this

Fitzpatrick, D., Laird, E., Ward, M., Hoey, L., Hughes, C. F., Strain, J. J., Cunningham, C., Healy, M., Molloy, A. M., McNulty, H., Lannon, R., & McCarroll, K. (2024). Secondary hyperparathyroidism: Predictors and relationship with vitamin D status, bone turnover markers and bone mineral density. Bone, 184, 1-10. Article 117108. https://doi.org/10.1016/j.bone.2024.117108

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abstract = "Secondary hyperparathyroidism (SHPT) has adverse implications for bone health but is relatively understudied. In this study we examine the prevalence and determinants of SHPT and describe the relationship of SHPT with bone turnover markers and bone mineral density (BMD) in older Irish adults. Eligible participants (n = 4139) were identified from the Trinity-Ulster-Department of Agriculture (TUDA) study, a cohort of Irish adults aged ≥60 years. Exclusion criteria included an estimated glomerular filtration rate (eGFR) 2.5 mmol/l to remove hyperparathyroidism due to advanced chronic kidney disease (CKD) and primary hyperparathyroidism respectively. The relationship between SHPT and bone turnover markers and BMD (measured by densitometry) was examined in a subsample (n = 1488). Vitamin D deficiency was defined as 25-hydroxyvitamin D [25 (OH)D]",

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AU - Hughes, Catherine F

AU - Strain, J J

AU - Cunningham, Conal

AU - Healy, Martin

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AU - Lannon, Rosaleen

AU - McCarroll, Kevin

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KW - Calcium supplementation

KW - Markers

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KW - Vitamin D

KW - Parathyroid hormone

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KW - Bone mineral density

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JF - Bone

M1 - 117108

ER -

Secondary hyperparathyroidism: Predictors and relationship with vitamin D status, bone turnover markers and bone mineral density

Abstract

Bibliographical note

Funding

UN SDGs

Keywords

Access to Document

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Cite this